The prevalence, risk factors, and screening measure for prediabetes and diabetes among Emirati overweight/obese children and adolescents

Amiri, Elham; Abdullatif, Mona; Abdulle, Abdishakur; Bitar, Nibal Al; Afandi, Elham Zaki; Parish, Monira; Darwiche, Gassan

doi:10.1186/s12889-015-2649-6

Cited by 79 publications

(92 citation statements)

References 37 publications

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“…Similar to previous published prevalence rates of type 2 diabetes, the present study found a predominance of females in these categories . The prevalence of prediabetes has been investigated in various countries across the world, including Mexico (1.5%), UAE (5.4%) and China (0.28%) . The studies emerging from the United States and Canada focus on adolescents who have been diagnosed with diabetes or present findings that estimate the prevalence of prediabetes and/or undiagnosed diabetes .…”

Section: Discussionsupporting

confidence: 87%

“…China (0.28%). [24][25][26] The studies emerging from the United States diabetes or present findings that estimate the prevalence of prediabetes and/or undiagnosed diabetes. 8,[27][28][29] In the present study, community-based screening was undertaken to determine the number of Canadian adolescents who were in the "at risk" or prediabetes and type 2 diabetes blood glucose range.…”

Section: Discussionmentioning

confidence: 99%

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Prediabetes: An emerging public health concern in adolescents

Spurr

Bally

Allan

et al. 2019

Endocrino Diabet & Metabol

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Summary Objectives To identify the presence of risk factors for type 2 diabetes (ethnicity, body mass index, blood glucose tolerance and blood pressure) and to determine the prevalence of prediabetes and type 2 diabetes in Canadian adolescents attending two multicultural urban high schools. Methods A total of 266 multicultural urban high school students who live in a mid‐sized Western Canadian city, aged 14‐21, were screened for risk factors of prediabetes and type 2 diabetes in March‐April 2018. Data with respect to demographics, family history of diabetes, anthropometrics, blood pressure and haemoglobin A1c (HbA1c) were collected. Data analysis was done using descriptive and inferential statistics in addition to chi‐square analyses. Results Based on body mass index, 38% of the adolescents were classified as either overweight or obese. Overweight rates for females (69.8%) were double than males (30.2%); however, males (52.2%) were more likely to obese than the females (47.8%). Based on HbA1c levels, 29.3% were at high risk to develop either diabetes or prediabetes and 2.6% were classified in the prediabetes range. Prehypertension/hypertension rates of 47% in the sample increased to 51% in those adolescents with elevated HbA1c; the majority of these prehypertensive/hypertensive participants were male. Conclusion High rates of overweight/obesity and prehypertension/hypertension were found in the adolescents studied and indicated the presence of prediabetes and an increased risk to develop type 2 diabetes and associated complications. Obesity and hypertension are major risk factors for developing type 2 diabetes, resulting in earlier exposure to metabolic consequences and, ultimately, long‐term complications. Thus, timely research is needed to identify age‐appropriate strategies that address risks and to develop recommendations for routine screening of adolescents for prediabetes.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Prediabetes: An emerging public health concern in adolescents

Spurr

Bally

Allan

et al. 2019

Endocrino Diabet & Metabol

View full text Add to dashboard Cite

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“…Regionally, among Saudi children and adolescents aged ≤18 years, prediabetes prevalence, defined based on ADA's IFG diagnostic criteria, was estimated to be 6.12% . In contrast, among obese/overweight Emirati children and adolescents (aged 11‐17 years), prediabetes prevalence was estimated to be 21.9% according to the HbA1c ADA criteria . As for international studies, prediabetes prevalence among the general population of children and adolescents in the United States (HbA1c ADA : 17.8%) and Taiwan (IFG ADA : 22.0%) were less than our estimated prevalence.…”

Section: Discussionmentioning

confidence: 99%

Associations of adiposity and parental diabetes with prediabetes among adolescents in Kuwait: A cross‐sectional study

Almari

Al-Saedi²,

Mohammad

et al. 2018

Pediatr Diabetes

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Background Prediabetes, a high‐risk state for developing diabetes, has become more prevalent among children and adolescents in recent decades. This study sought to estimate the prevalence of prediabetes and assess its association with adiposity among adolescents in Kuwait. Also, to determine whether maternal and paternal history of diabetes associate with offspring prediabetes in a sex‐specific manner. Methods A cross‐sectional study was conducted by enrolling students (n = 1959; aged 14‐19 years) attending high schools across Kuwait. Body mass index‐for‐age z‐scores were estimated using the World Health Organization growth reference. Glycated hemoglobin A1c (HbA1c) was measured in capillary blood using point‐of‐care testing. Prediabetes was defined according to the diagnostic criteria of the American Diabetes Association (ADA; 5.7 ≤ HbA1c% ≤ 6.4) and the International Expert Committee (IEC; 6.0 ≤ HbA1c% ≤ 6.4). Adjusted prevalence ratios (aPR) and 95% confidence intervals (CI) were estimated using Poisson regression with robust variance estimation. Results According to the ADA criteria, 33.3% (620/1845) of participants had prediabetes; whereas, 8.5% (157/1845) met the IEC definition for prediabetes. Subjects classified as obese had higher prevalence of prediabetes compared to children in the thinness/normal group (aPR = 1.68, 95% CI: 1.44‐1.95). Analysis stratified by offspring sex showed that maternal history of diabetes is associated with prediabetes among male offspring (aPR = 1.29, 95% CI: 1.02‐1.63). In contrast, paternal history of diabetes showed an association with prediabetes among female offspring (aPR = 1.22, 95% CI: 1.01‐1.48). Conclusions Prediabetes affects a substantial proportion of adolescents in Kuwait and adiposity and parental diabetes being the main associated factors with prediabetes.

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“…Another important risk factor is family history. In a study conducted by Elham Al Almiri and co‐authors, more than half of prediabetic patients and all with T2D had a first‐degree relative with T2D . Prediabetes (20%) and diabetes (70%) participants had also raised triglyceride levels …”

Section: Overweight and Obesity In T2dmentioning

confidence: 98%

Obesity and diabetes—Not only a simple link between two epidemics

Chobot¹,

Górowska-Kowolik²,

Sokołowska

et al. 2018

Diabetes Metabolism Res

221

158

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SummaryDiabetes (DM) as well as obesity, due to their increasing incidence, were recognized as epidemic by the World Health Organization. Obesity is involved not only in the aetiopathogenesis of the most common worldwide type of DM—type 2 diabetes—but also in the development of its complications. There is also increasing scientific evidence regarding the role of obesity and overweight in type 1 diabetes. Weight gain may be considered as a complication of insulin treatment but also reveals significant pathophysiological impact on various stages of the disease. Another very important aspect related to DM as well as obesity is the microbiome, which is highly variable. The function of the gut microflora, its interaction with the whole organism, and its role in the development of obesity and type 1 diabetes as well as type 2 diabetes are still not fully understood and subject of ongoing investigations. This review presents a summary of recently published results concerning the relation of obesity/overweight and DM as well as their associations with the microbiome.

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The prevalence, risk factors, and screening measure for prediabetes and diabetes among Emirati overweight/obese children and adolescents

Cited by 79 publications

References 37 publications

Prediabetes: An emerging public health concern in adolescents

Prediabetes: An emerging public health concern in adolescents

Associations of adiposity and parental diabetes with prediabetes among adolescents in Kuwait: A cross‐sectional study

Obesity and diabetes—Not only a simple link between two epidemics

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