The prevalence rate of periodontal pathogens and its association with oral squamous cell carcinoma

Chang, Chun‐Hsi; Geng, Fei; Shi, Xiaoting; Li, Yuchao; Zhang, Xue; Zhao, Xida; Pan, Yaping

doi:10.1007/s00253-018-9475-6

Cited by 79 publications

(96 citation statements)

References 45 publications

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“…To exclude contamination of samples, we examined the presence of Pg in OSCC tissue by ISH. There was high enrichment of Pg in OSCC tissue compared with normal tissue adjacent to OSCC, as previous study [3] . After an average follow-up period of 13 months, the disease recurred in 18.1% (17/94) of our patients.…”

Section: Discussionsupporting

confidence: 86%

“…Unexpectedly, we found the overabundance of Pg is a prognostic factor for longer DFS. Contrary to popular belief, they found that Pg was associated with higher risk of pancreatic cancer [26,27] , esophageal squamous cell carcinoma [28,29] and oral squamous cell carcinoma [3] . Meanwhile, Pg was associated with overall survival rate in esophageal squamous cell carcinoma [30] .…”

Section: Discussioncontrasting

confidence: 59%

“…Pg increased the size and the multiplicity of carcinoma to promote the development of oral cancer [5] . Previous studies have con rmed the association between Pg and OSCC by examining the abundance of Pg in saliva of patients, and unveiled that patients with medium and poor differentiation, overall clinical stage III and stage IV as well as lymph node metastasis suggested association with Pg involvement [3] . Our study also veri ed the overabundance of Pg from OSCC patients compared with non-OSCC subjects in saliva.…”

Section: Discussionmentioning

confidence: 98%

“…Porphyromonas gingivalis (Pg), an anaerobic Gram-negative bacterium, has been suggested that correlates to OSCC in extensively studies [3][4][5][6][7][8][9] . But the abundance of Pg capable of predicting the recurrence as a biomarker still unknown.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic Role of Porphyromonas Gingivalis in Oral Cavity Squamous Cell Carcinoma Patients

Chen

Shao

Liu

et al. 2020

Preprint

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Background: Oral microbial species play direct and/or indirect role in carcinogenesis of oral cavity squamous cell carcinoma (OSCC). Porphyromonas gingivalis (Pg) has been identified a correlation with OSCC. Fimbriae play a vital role for its attribution of initial attachment and adhesion of Pg. Six genotypes (types I-V, Ib) of fimA were identified based on sequence variations and the genotype was suggested a relationship to pathogenicity of Pg.Objective: To investigate the abundance of Pg in OSCC as well as the frequency of Pg fimA genotypes in OSCC patients.Methods: Ninety-five OSCC patients and thirty-nine gender- and age-matched non-OSCC subjects were investigated abundance of Pg in saliva. Presence of Pg was compared in OSCC tissue and para-cancerous tissue from patient as well. Clinical data were extracted and patients followed up for a mean period of 13 months. Presence of Pg and fimA genotypes were investigated in OSCC tissue and in saliva, then PCR products were sequencing and compared.Results: OSCC patients showed high abundance of Pg in saliva (Chi-square=14.531, P=0.001). OSCC tissue showed strong in situ expression of Pg by in situ hybridization compared with normal tissue adjacent to OSCC. Patients with overabundance of Pg in saliva are associated with systemic disease (Chi-square=10.328, P=0.029), longer disease-free time (Z=-2.988, P=0.003), and lower recurrence rate (Chi-square=5.670, P=0.017). The abundance of Pg was an independent favorable prognostic factor (HR: 0.124, 95%CI: 0.016 to 0.941). There was dominant distribution of Pg with genotype I+Ib (21.1%), II (31.6%) and IV (21.1%) in OSCC patients. The fimA genotypes detected in saliva were in accordance with those in OSCC tissue, and there was significantly correlation in amplified Pg fragments similarity between in saliva and in OSCC tissue. Conclusions: This study indicated that Pg might involve in the pathogenesis of OSCC, and Pg might consider as a potential prognostic indicator in OSCC. There was a dominant distribution of Pg with genotypes I, Ib, II and IV in OSCC patients. The presence of Pg in tumor might be saliva in provenance.

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Section: Discussionsupporting

confidence: 86%

Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Prognostic Role of Porphyromonas Gingivalis in Oral Cavity Squamous Cell Carcinoma Patients

Chen

Shao

Liu

et al. 2020

Preprint

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“…Gonda et al reported that chronic inflammation induced by bacterial infection drove carcinogenesis, involving induction, progression, invasion, and metastasis [33]. It is believed that the inflammatory microenvironment was an integral part of oral cancer [2,[32][33][34][35]46,47].…”

Section: Figurementioning

confidence: 99%

Distinct gene expression characteristics in epithelial cell-Porphyromonas gingivalis interactions by integrating transcriptome analyses

et al. 2019

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Porphyromonas gingivalis is a pivotal periodontal pathogen, and the epithelial cells serve as the first physical barrier to defend the host from bacterial attack. Within this host-bacteria interaction, P. gingivalis can modify the host immune reaction and adjust the gene expression, which is associated with periodontitis pathogenesis and developing strategies. Herein, a meta-analysis was made to get the differential gene expression profiles in epithelial cells with or without P. gingivalis infection. The network-based meta-analysis program for gene expression profiling was used. Both the gene ontology analysis and the pathway enrichment analysis of the differentially expressed genes were conducted. Our results determined that 290 genes were consistently up-regulated in P. gingivalis infected epithelial cells. 229 gene ontology biological process terms of up-regulated genes were discovered, including "negative regulation of apoptotic process" and "positive regulation of cell proliferation/migration/angiogenesis". In addition to the well-known inflammatory signaling pathways, the pathway associated with a transcriptional misregulation in cancer has also been increased. Our findings indicated that P. gingivalis benefited from the survival of epithelial cells, and got its success as a colonizer in oral epithelium. The results also suggested that infection of P. gingivalis might contribute to oral cancer through chronic inflammation. Negative regulation of the apoptotic process and transcriptional misregulation in cancer pathway are important contributors to the cellular physiology changes during infection development, which have particular relevance to the pathogenesis and progressions of periodontitis, even to the occurrence of oral cancer.

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Roles of intralesional bacteria in the initiation and progression of oral squamous cell carcinoma

Luo,

Lv,

Lou

et al. 2024

Cancer Medicine

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BackgroundOral squamous cell carcinoma (OSCC) is the predominant form of head and neck cancer, often diagnosed at late stages, resulting in a poor prognosis. Recent studies indicate a potential association between OSCC and microbial presence. Microorganisms have been identified in various tumors and lesions, including OSCC and oral potentially malignant disorders (OPMDs). Intralesional microbiota are considered important components of the tumor microenvironment (TME) and may contribute to carcinogenesis.MethodsSources were collected through thorough searches of databases PubMed and Embase. The review focused on microbial characteristics, potential origins, and their impact on cancer progression.ResultsBacteria display varying abundance and diversity throughout the stages of OSCC and OPMDs. Intraleisional bacteria may have diverse sources, including not only oral plaque and saliva but also potentially the gut. Intralesional bacteria have both pro‐carcinogenic and anti‐carcinogenic effects, affecting processes like cell proliferation, invasion, and immune response.ConclusionsIntralesional microbiota are crucial in OSCC and OPMDs, influencing both disease progression and treatments. Despite their significance, challenges like inconsistent sampling and microbial identification remain. Future research is required to fully understand their role and improve clinical applications.

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The prevalence rate of periodontal pathogens and its association with oral squamous cell carcinoma

Cited by 79 publications

References 45 publications

Prognostic Role of Porphyromonas Gingivalis in Oral Cavity Squamous Cell Carcinoma Patients

Prognostic Role of Porphyromonas Gingivalis in Oral Cavity Squamous Cell Carcinoma Patients

Distinct gene expression characteristics in epithelial cell-Porphyromonas gingivalis interactions by integrating transcriptome analyses

Roles of intralesional bacteria in the initiation and progression of oral squamous cell carcinoma

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