The prevalence of vitamin D deficiency in Russian Federation

Petrushkina, Alexandra; Александровна, Петрушкина Александра; Pigarova, Ekaterina; Александровна, Пигарова Екатерина; Rozhinskaya, Liudmila; Яковлевна, Рожинская Людмила

doi:10.14341/osteo10038

Cited by 32 publications

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“…Согласно инструкции, для коррекции выявленного дефицита или недостаточности витамина D рекомендован ежедневный прием двух капсул ФортеДетрим ® по 4 000 МЕ или прием в режиме 1 раз в неделю 5 капсул по 10 000 МЕ (в течение 8 недель при лечении дефицита, в течение 4 недель при лечении недостаточности) 1 .…”

Section: прегравидарная подготовка и беременностьunclassified

“…Дефицит VD характеризуется гендерными различиями: среди женщин его частота достигает 89-95,5%, среди мужчин -47,25-77,8%. Патогенетические механизмы развития гиповитаминоза преимущественно связаны с неполноценным синтезом эндогенного VD вследствие недостаточной инсоляции и в меньшей -его недостаточного потребления с продуктами питания [1]. Сезонные колебания VD варьируются от максимальных значений в сентябре -октябре до минимальных в январе -апреле.…”

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“…Именно при взаимодействии VD-R с собственным лигандом реализуется многообразие биологических эффектов. Учитывая гормональную активность VD, некоторые авторы предлагают использовать термин D-гормон [2]. Ранее проведенные исследования позволили сформировать четкое представление о классическом влиянии VD на кальциево-фосфорный обмен.…”

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Ovarian effects of vitamin D: a systematic review

Chernukha

Yakushevskaya

2021

Medicinskij sovet

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The history of the discovery of vitamin D (VD) has crossed 100 years. Initially, VD deficiency was limitedly associated with the development of rickets in children. Later, on the basis of a number of studies, it was found that VD deficiency is a risk factor for osteoporosis in men and women. However, the traditional concept of VD as the main regulator of calcium-phosphorus metabolism has undergone dramatic changes over the past two decades. A prerequisite for revising the role of VD and the spectrum of its biological properties was the identification of the distribution of its specific receptors in the body. VD receptors are expressed in the intestine, thyroid and parathyroid glands, kidneys, ovaries, uterus, placenta, hypothalamus, pituitary gland and play a vital function not only in calcium homeostasis. Accordingly, the list of target organs for VD action has been modified. VD deficiency, calculated on a pandemic scale, is a factor that increases the risk of developing not only osteoporosis, but also a number of other diseases. Observational and epidemiological studies have shown that reproductive system disorders are very often combined with VD insufficiency / deficiency. Subsequent scientific research aimed at establishing the role of VD in the formation of a particular pathology of the reproductive system has shown very ambiguous results. VD is recognized as an essential component of maintaining a woman’s reproductive health. Of course, the presence of an established association is not evidence of a causal relationship. There is a need for additional testing. This review focuses on the effect of VD on ovarian function and the formation of various dysfunctional conditions.

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Section: прегравидарная подготовка и беременностьunclassified

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Ovarian effects of vitamin D: a systematic review

Chernukha

Yakushevskaya

2021

Medicinskij sovet

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“…Ввиду широкого распространения недостаточности и дефицита витамина D как во всем мире [15], так и в России [16] имеется настоятельная необходимость в наличии широкого спектра медицинских препаратов витамина D (колекальциферола) в разных дозировках и лекарственных формах для адекватного применения в насыщающих и поддерживающих дозах для лечения дефицита витамина D.…”

Section: обсуждение результатовunclassified

High-doses of cholecalciferol for vitamin D deficiency treatment: results of an open-label, multicenter, comparative, randomized trial

Рожинская¹,

Pigarova²,

Багрецова

et al. 2021

Osteopor Bone Dis

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Background: Vitamin D deficiency have serious medical, social and economic consequences for human health and require timely diagnosis and adequate correction.Aim: Evaluation of the efficacy and safety of therapy with Fortedetrim soft capsules (MEDANA PHARMA AO, Poland) using saturating and maintenance doses compared to therapy with Vigantol®, an oily solution for oral administration (Merck KGaA, Germany) in patients with vitamin D deficiency.Materials and methods: The study included 150 patients with vitamin D deficiency (less than 20 ng/ml) aged 18 to 75 years, who were randomized into 3 groups in a 1:1:1 ratio (50 people each). Fortedetrim capsules were used in two groups during the first four weeks 50,000 IU once a week (5 capsules 10,000 IU each) and 56,000 IU — 8,000 IU daily (2 capsules 4000 IU), and Vigantol® was used in the comparison group 1000 IU daily (2 drops). Over the next 12 weeks, patients received supportive therapy — in the first group, Fortedetrim 10,000 IU was used once a week, in the second — Fortedetrim 2,000 IU daily (14,000 IU per week); the comparison group continued to take Vigantol® 1000 IU daily.Results: As a result of evaluating the data on the results of stages I and II of the clinical study Fortedetrim in comparison with Vigantol®, the hypothesis was proved that the high-dose drug Fortedetrim (capsules of 2000, 4000 and 10000 IU) is superior to the drug Vigantol® (drops, 1000 IU daily). Nevertheless, it should be noted that long-term intake of colecalciferol at a dose of 1000 IU daily by 20 weeks allowed 36% of participants to reach a level of 30 ng/ml, but this is significantly less than in groups using high-dose drugs. There were no differences in the number of adverse events during the study, their degree and the relationship with drug intake between the treatment and comparison groups.Conclusion: The use of the drug Fortedetrim in saturating doses is effective and safe for the treatment of adult patients with vitamin D deficiency. However, an individual approach to its replenishment is required (taking into account compliance, the degree of obesity, impaired absorption of calcium and vitamin D), since not all patients in the applied saturation regimes, the target values of vitamin D in the blood were reached.

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“…По данным многочисленных исследований, распространённость дефицита/недостаточности витамина D очень широка [9] -около 40% по данным исследования в США [10], 69% в Германии [11], 56% в странах Африки [12] и до 82% в Арабских эмиратах [13]. В Российской Федерации распространённость дефицита/недостаточности витамина D в различных регионах составляет от 74% [14] до 94% [15]. Кроме того, по результатам пилотных исследований в Российской Федерации также высока распространенность гипокальциемии и достигает 16,5% среди относительно здоровых лиц в возрасте младше 50 лет [16]…”

Section: паратироцитыunclassified

Influence of deficiency or insufficiency of vitamin D on the circadian rhythm of serum calcium level

et al. 2020

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Background: mild hypocalcemia is a common laboratory finding that is not accompanied by the clinical symptoms. The most common causes of hypocalcemia are inadequate calcium intake and vitamin D deficiency. Given the high prevalence of vitamin D deficiency (insufficiency), it seems relevant to determine the daily variability of serum calcium levels before and after its supplementation.Aims: to assess the effect of 25(OH) vitamin D level on the daily profile of serum calcium and 24-hour urinary calcium levels. MATERIALS AND METHODS: the interventional, prospective, comparative study of 10 healthy volunteers (women/men - 9/1) was performed. We have analyzed the daily profiles of serum calcium and 24-hour urinary calcium levels. Summary duration of this study was 8 months and consisted two hospitalizations. Statistical analysis was done on August 2020. The descriptive statistics are represented by medians and the first and third quartiles in Me (Q1; Q3), average, maximum, and minimum values M (min; max) and by absolute and relative frequencies.Results: Me serum calcium levels (Catotaland Cacorr.) and 24-hour urinary calcium levels did not differ before and after vitamin D supplementation. However, the number of reference calcium values increased as 25 (OH) vitamin D level was reached more than 30 ng/ml from 90.8% to 100% for Catotal and from 94.2% to 97.5% for Cacorr. Episodes of hypocalcemia were registered in patients with low vitamin D levels: in 3.33% of cases according to Catotal and 5.8% for Cacorr. The frequency of hypocalcemia decreased for Catotal (to 0%) and for Cacorr. (to 2.5%) after treatment with cholecalciferol. Analysis of Catotal and Cacorr. deviations during the day showed a less variability of the calcium profile after treatment, This study also revealed circadian character of daily serum calcium profile with the presence of maximum (09:40-17:40) and minimum (23:40-07:40) values during the day.Conclusions: Our study demonstrated the improvement of daily serum calcium profile after vitamin D supplementation. We confirmed the increased number of reference calcium values, decreased variability of serum calcium levels during the day and decreased frequency of hypocalcemia.

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The prevalence of vitamin D deficiency in Russian Federation

Cited by 32 publications

References 16 publications

Ovarian effects of vitamin D: a systematic review

Ovarian effects of vitamin D: a systematic review

High-doses of cholecalciferol for vitamin D deficiency treatment: results of an open-label, multicenter, comparative, randomized trial

Influence of deficiency or insufficiency of vitamin D on the circadian rhythm of serum calcium level

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