The prevalence of urinary tract infection, or urosepsis following transrectal ultrasound-guided prostate biopsy in a subset of the Saudi population and patterns of susceptibility to flouroquinolones

Abstract

Objectives:To study the prevalence of urinary tract infections (UTI), or sepsis secondary to trans-rectal ultrasound-guided (TRUS) biopsy of the prostate, the pathogens involved, and patterns of antibiotic resistance in a cohort of patients.Methods:This is a descriptive study of a consecutive cohort of patients who underwent elective TRUS biopsy at King Abdulaziz Medical City Riyadh, Saudi Arabia between January 2012 and December 2014. All patients who underwent the TRUS guided prostate biopsy were prescribed the standard prophylactic antibiotics. Variables included were patients’ demographics, type of antibiotic prophylaxis, results of biopsy, the rate of UTI, and urosepsis with the type of pathogen(s) involved and its/their antimicrobial sensitivity.Results:Simple descriptive statistics were used in a total of 139 consecutive patients. Urosepsis requiring hospital admission was encountered in 7 (5%) patients and uncomplicated UTI was observed in 4 (2.8%). The most common pathogens were Escherichia coli (90.1%) and Klebsiella pneumoniae (9.1%). Resistance to the routinely used prophylaxis (ciprofloxacin) was observed in 10 of these patients (90.9%).Conclusion:This showed an increase in the rate of infectious complications after TRUS prostate biopsy. Ciprofloxacin resistance was found in 90.9% of patients with no sepsis.

Epidemiology and Antimicrobial Susceptibility Pattern of Uropathogens in Patients with the Community- and Hospital-Acquired Urinary Tract Infections at a Tertiary Hospital in Somalia

“…The prevalence of uropathogens that showed growth in the urine cultures was 14.5%. We studied a total of 2,845 patients, and females displayed a slight predominance in our research (51% of the total cases), which is consistent with other studies conducted in Ethiopia, India, and Saudi Arabia (11)(12)(13). This could be due to several predisposing factors specific to women (14).…”

“…The most common prevailing uropathogen in both community-and hospital-acquired UTI in the current study was E. coli in 63.4% of the cases (two-thirds), followed by K. pneumonia (13.3%), and P. aeruginosa (3.9%), which is comparable to the previous studies (12,13). The present study demonstrated the highest resistance rate to uropathogens by cefepime (100%), ampicillin (94.5%), cefuroxime 94.5%), cefazolin (88.7%), cefixime (83.3%), and ceftriaxone (82.4%), which is consistent with earlier studies conducted in Ethiopia and India (11,15).…”

Incidence and molecular characterization of the extended spectrum beta lactamase-producing Escherichia coli isolated from urinary tract infections in Eastern Saudi Arabia

“…Escherichia coli is the most common organism causing UTIs both in the community and hospital settings. 15 Antimicrobial resistance is increasing at an alarming rate in these pathogens due to genetic recombination. 16 Extended spectrum beta lactamase production is a pivotal mechanism used by these pathogens to jeopardize UTI treatment options.…”

<p>Retrospective Study of the Etiology and Risk Factors of Systemic Inflammatory Response Syndrome After Systematic Transrectal Ultrasound-Guided Prostate Biopsy</p>

“… 28 – 30 Unfortunately, in recent years, studies have found that the pathogenic bacteria Escherichia coli after TURS-PB resistance to quinolone antibiotics is as high as 80–90%. 29 , 31 , 32 In this study, we found that SIRS pathogens after TRUS-Bx showed strong resistance to levofloxacin, ciprofloxacin, gentamycin, penicillin G, compound Xinnuoming and the second-generation cephalosporins, with a resistance rate of 42.86%–80.95%. Therefore, we suggest that the preventive use of levofloxacin may need to be adjusted.…”