The Prevalence of Type 2 Diabetes and Hypertension in Uygur and Kazak Populations

Tao, Yicun; Mao, Xinmin; Xie, Zongping; Ran, Xin; Liu, Xiaoyan; Wang, Ye; Luo, Xin; Hu, Mengying; Gen, Wenning; Zhang, Minfang; Wang, Tao; Ren, Jun; Wufuer, Hamulati; Li, Linlin

doi:10.1007/s12012-008-9024-0

Cited by 27 publications

(31 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some studies indicated that sex hormone level was an independent risk factor for dyslipidemia [27]. Third, The overall prevalence of diabetes was generally low (1.56%) in this study, which was similar with previous Kazakh reports (1.47-3.65%) [28,29], but much lower than 9.7% of the national average level [30]. Unlike previous studies, which reported that diabetes tended to be bundled with hypertension, and that there was substantial overlap between diabetes mellitus and hypertension in etiology and disease mechanisms, our results revealed that diabetes mellitus was a relatively independent disease, and 3.1% of hypertension patients had a coinstantaneous type 2 diabetes mellitus.…”

Section: Epidemic Of Cardiovascular Risk Factorssupporting

confidence: 90%

Cardiovascular Risk Factors and its Transition: An Ongoing Cohort Study in Chinese Kazakhs

Jiang¹,

Zhang²,

Hou³

et al. 2017

Recent Trends in Cardiovascular Risks

View full text Add to dashboard Cite

Studies on the prevalence of risk factors and the incidence for cardiovascular diseases (CVDs) are limited in Kazakh population. By incorporating nomads, farmers, and urban residents, aged 30 years or older, in a cohort study, we investigated the characteristics of cardiovascular risk factors and their temporal trends that arose from the urbanization and subsequent changes in the lifestyle in a Kazakh population with 1668 participants. We used current guidelines and the monitoring trends and determinants in cardiovascular disease (MONICA) standard to define cardiovascular events. Kazakhs had a high prevalence rate of hypertension (45.3%), and this prevalence was much higher than the national average in China. Prevalence of two or more risk factors was highest among urban people and lowest among nomads. Urban residents have the highest prevalence of hypercholesterolemia and obesity compared with farmers and nomads. However, unlike other studies, our data indicate that young men had the highest prevalence of dyslipidemia, and it decreased significantly thereafter. Crude rates of incidence and mortality for acute cardiovascular events were 742 and 194 per 100,000 people, respectively; the standardized rates were 926 and 272 per 100,000 people, respectively. The findings from this study demonstrate the pervasive burden of cardiovascular risk factors and the related acute cardiovascular events in Kazakhs, particularly BP in Kazakh nomads.

show abstract

Section: Epidemic Of Cardiovascular Risk Factorssupporting

confidence: 90%

Cardiovascular Risk Factors and its Transition: An Ongoing Cohort Study in Chinese Kazakhs

Jiang¹,

Zhang²,

Hou³

et al. 2017

Recent Trends in Cardiovascular Risks

View full text Add to dashboard Cite

show abstract

“…In a previous study, we reported that the prevalence of adult diabetes in the Xinjiang Uygur population of western China was 6.23% (Yang et al, 2012). Tao et al (2008) reported that the prevalence of diabetes was 8.16% in the Uygur population and was 1.47% in the Kazak population in 2008, whereas Awuti et al (2012) reported a diabetes prevalence of 9.0% in the Uygur population in 2010. Fu et al (2007) found that the prevalence of diabetes in Chinese children and adolescents was 0.19%, and Cao et al (2007) found total age-adjusted prevalence rates of diabetes and IFG of 0.57 and 1.35% in Beijing children.…”

Section: Introductionmentioning

confidence: 90%

Prevalence of diabetes and impaired fasting glucose in Uygur children of Xinjiang, China

Zhang

Ma²,

Xie³

et al. 2013

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. This study was designed to estimate the prevalence of diabetes and impaired fasting glucose (IFG) in Xinjiang children in western China. Data were obtained from the Chun-Miao Project, a community-based, cross-sectional study designed to investigate the prevalence and risk factors of diabetes in children of the Chinese Uygur population in Xinjiang from February 2010 to May 2012. A total of 3644 children completed the survey and measurements of fasting glucose. Diabetes and IFG were defined using American Diabetes Association 2009 criteria. Overall, 0.7% of the 3644 Uygur children had IFG and 0.1% had diabetes. In the newborn to 8-year-old group, the prevalence of diabetes and IFG was 0.6 and 1.1%, respectively. In the 9-13-year-old group, the prevalence of diabetes and IFG was 0.1 and 0.7%, respectively. There was no evidence of IFG or diabetes in the 14-17-year-old group. Logistic regression analysis suggested that overweight and obesity were independent risk factors of diabetes in Uygur children of Xinjiang. The prevalence of diabetes and IFG in Uygur children was lower than that reported previously in children of other ethnicities in China.

show abstract

“…The rate of T2DM in the Kazakh population in China is much lower than in the Han population in this region, despite the significant incidence of obesity, insulin resistance, and other risk factors in the Kazakh population (Tao et al, 2008). Therefore, we investigated the contribution of KCNQ1 to the etiology of T2DM in the Chinese Kazakh population to determine whether variants of KCNQ1 were associated with susceptibility to T2DM and diabetes-related metabolic traits.…”

Section: Introductionmentioning

confidence: 99%

Relationship between the polymorphisms in KCNQ1 and type 2 diabetes in Chinese Kazakh population

Cui¹,

Xy²,

Ly³

et al. 2016

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Recently genome-wide association studies on East Asian populations reported an association between diabetes and several single nucleotide polymorphisms (SNPs) in a 40-kb linkage disequilibrium block in intron 15 of KCNQ1. However, the association between KCNQ1 variants and type 2 diabetes mellitus (T2DM) in Chinese Kazakh populations is unknown. We investigated the relationship between rs2237892 and rs2237895 SNPs in KCNQ1 and susceptibility to and clinical characteristics of T2DM in 100 Chinese Kazakh T2DM subjects and 100 healthy subjects. SNPs were genotyped by polymerase chain reaction-restriction fragment length polymorphism and the main anthropometric and biochemical parameters of individuals were assessed in the genotype groups (rs2237892: CC, CT, or TT, and rs2237895: AA, AC, or CC). Genotype distribution and allele frequencies of these two SNPs were not significantly different between T2DM and control groups (P > 0.05). The frequencies of CT and TT genotypes and T allele for the rs2237892 SNP in females with T2DM were significantly higher than that in the control group (genotype: P = 0.016, allele: P = 0.004). However, there were no significant differences among individuals with different genotypes with respect to the rs2237895 SNP (P > 0.05). The main anthropometric and biochemical parameters did not correlate with the rs2237892 or rs2237895 SNPs in the T2DM group (P > 0.05). Thus, the T allele-containing genotypes of the rs2237892 SNP in KCNQ1 may increase the susceptibility to T2DM in female Chinese Kazakh individuals, whereas the rs2237895 SNP may not be associated with T2DM in the Chinese Kazakh population.

show abstract

The Prevalence of Type 2 Diabetes and Hypertension in Uygur and Kazak Populations

Cited by 27 publications

References 7 publications

Cardiovascular Risk Factors and its Transition: An Ongoing Cohort Study in Chinese Kazakhs

Cardiovascular Risk Factors and its Transition: An Ongoing Cohort Study in Chinese Kazakhs

Prevalence of diabetes and impaired fasting glucose in Uygur children of Xinjiang, China

Relationship between the polymorphisms in KCNQ1 and type 2 diabetes in Chinese Kazakh population

Contact Info

Product

Resources

About