The prevalence of thyroid disease in patients with vitiligo: a systematic review

Vrijman, Charlotte; Kroon, Marije W.; Limpens, Jacqueline; Leeflang, Mariska; Luiten, Rosalie M.; Veen, J.P.W. van der; Wolkerstorfer, Albert; Spuls, Phyllis I.

doi:10.1111/j.1365-2133.2012.11198.x

Cited by 100 publications

(92 citation statements)

References 64 publications

(78 reference statements)

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“…However, data not supporting this statement also exist [44]. A recent systematic review from Vrijman et al [58] included 48 studies out of 1,167 examined of which only 6 were of good methodological quality. The review concluded that there is evidence of an increased prevalence and an increased risk of autoimmune thyroid disease in vitiligo patients, and that the risk seems to increase with age.…”

Section: Discussionmentioning

confidence: 99%

Circulating Autoantibodies and Autoimmune Comorbidities in Vitiligo Patients: A Multicenter Italian Study

et al. 2014

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Background: Autoimmune comorbidities and circulating autoantibodies have been observed in vitiligo patients, but differences in rate are present according to countries in which the studies were performed, perhaps owing to ethnic diversities or different trigger factors. Objective: To estimate the prevalence of circulating autoantibodies and overt autoimmune diseases in a fairly large sample of Italian vitiligo patients. Methods: 175 outpatients affected by vitiligo and referred to nine dermatological centers were included in the study. Patients were offered routine blood test, serological testing for thyroid function and search for autoantibodies. Results: At least one circulating autoantibody was detected in 61 (41.8%) of 146 subjects who underwent laboratory tests. Anti-thyroperoxidase (25.6%), anti-thyroglobulin (23.4%), antinuclear antibodies (16.8%) and anti-gastric parietal cell antibodies (7.8%) were the most noticed autoantibodies. 74 (41.5%) autoimmune comorbidities, mainly autoimmune thyroiditis (37%), were reported. Conclusion: The prevalence of autoimmune comorbidities and circulating autoantibodies in this study was in agreement with other surveys conducted on Caucasian patients.

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Section: Discussionmentioning

confidence: 99%

Circulating Autoantibodies and Autoimmune Comorbidities in Vitiligo Patients: A Multicenter Italian Study

et al. 2014

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“…A previous study by Dave et al reported 31.4% prevalence of thyroid-specific autoantibodies in patients with vitiligo [37]. A more recent study reported a mean prevalence of 20.8% in patients with vitiligo [38]. Again, KasumagicHalilovic et al found higher frequency of anti-TPO in vitiligo patients than control group [39].…”

Section: Anti-thyroid Peroxidase (Anti-tpo)mentioning

confidence: 83%

Autoantibodies Profile in Vitiligo

Hamid¹,

Bitsue²,

Mirshafiey³

2015

Pigmentary Disorders

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Vitiligo is one of the disease which is yet to understand its pathogenesis, however many studies associate this disease as an autoimmune. Detection of autoimmune cells in the serum, lesional and perilesional area of vitiligo patients gives more insight on the disease mechanism. Presence of autoantibodies against melanocytes antigens in vitiligo patients indicates an autoimmune involvement in the aetiology of the disease. Identification and characterization of vitiligo autoantibodies would pave the way for developing new laboratory test for diagnosis. Studying the autoantibodies profile can give an impression on the disease condition of vitiligo patients. We realized the need of research emphasis in this area as more is yet to be discovered. In this review we give an account on different autoantibodies and their associated autoantigens in vitiligo as another effort of providing an updated data for detail analysis.

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“…Among these diseases, lichen planus, pernicious anemia, Hashimoto's thyroiditis, hypothyroidism, endemic goiter, diabetes mellitus, lupus erythematosus, and Graves' disease. However, the chance of coexistence with autoimmune thyroid diseases is higher than the others [9][10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Thyroid Dysfunction in Libyan Vitiligo Patients

SA¹,

Na²

2017

IJCDR

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Background: Vitiligo is an acquired depigmenting disorder due to destruction of melanocytes, many hypotheses have been suggested for its pathogenesis. One of these hypotheses suggest that there are autoimmune and endocrine dysfunction involvement. The involvement of vitiligo with thyroid autoimmune diseases, with the increased prevalence of auto antibodies including thyroid auto antibodies in vitiligo support the hypothesis. Patients and Methods: 50 Libyan patients under same age and gender with vitiligo, and 50 controls . Patients were excluded if they had a history of thyroid, or other autoimmune diseases. Data on age, onset of illness, duration and disease activity were determined . Serum T3, T4, TSH , and antibodies to TPO and TG were measured in both vitiligo patients & controls. All patients and control subjects underwent thyroid ultrasonography. Results: Fifty patients with vitiligo and their 50 matched controls were studied. More than half of the patients (52%) were females and 48% were males, their mean of age was 40 ± 11 years, and the duration of vitiligo was 11± 9 years. Vitiligo vulgaris type was the most common form seen in 68% of the patients, and 42% reported at least one family member affected with vitiligo. Family history of thyroid disorder was seen in 20% of the patients. Thyroid functional abnormalities were significantly seen more in patients than control subjects. The frequency of TG and TPO thyroid autoantibodies was significantly higher in vitiligo patients than in healthy controls (P < 0.01). Abnormal thyroid ultrasound study was seen in 18 (36%) of the patients compared to 6 (12%) of the control subjects (P < 0.05). Conclusion: Our findings pointed to a significant association between vitiligo and thyroid autoimmunity and showed that testing the level of thyroid autoantibodies is relevant in vitiligo patients.

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The prevalence of thyroid disease in patients with vitiligo: a systematic review

Cited by 100 publications

References 64 publications

Circulating Autoantibodies and Autoimmune Comorbidities in Vitiligo Patients: A Multicenter Italian Study

Circulating Autoantibodies and Autoimmune Comorbidities in Vitiligo Patients: A Multicenter Italian Study

Autoantibodies Profile in Vitiligo

Thyroid Dysfunction in Libyan Vitiligo Patients

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