“…Previous reports have identified the presence of the J wave as a normal variant in humans, baboons, and dogs [ 2 , 5 , 19 ], while other studies have observed the J wave under pathological conditions, including hypercalcemia [ 16 , 19 , 23 ], ischemic heart disease [ 11 , 15 , 25 ], left ventricular hypertrophy [ 18 , 25 ], and fatal arrhythmia. Characteristic J wave abnormalities have been reported in Brugada syndrome—an inherited arrhythmic condition characterized by ST elevation, negative T wave in the right chest leads, and no evidence of structural cardiac abnormalities [ 3 , 14 ]—as well as in early repolarization syndrome, in which J waves are associated with life-threatening cardiac events [ 19 , 20 , 25 ], as they are in human patients with hypertrophic cardiomyopathy [ 11 ]. The J wave occurs as a normal variant in 43% of geriatric dogs without cardiovascular disease, as well as in 29.1% of geriatric dogs with cardiovascular diseases [ 16 , 19 ].…”