The prevalence of Th17 cells in patients with gastric cancer

Zhou, Bin; Rong, Guanghua; Wei, Huafeng; Zhang, Meng; Bi, Jiacheng; Ma, Long; Xue, Xindong; Guo, Wei; Liu, Xiao-Kang; Fang, Guoen

doi:10.1016/j.bbrc.2008.07.060

Cited by 236 publications

(200 citation statements)

References 31 publications

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“…It can stimulate the immune response, clear the pathogens and cancerous cells or tissues, and participate in the inflammation reaction (Park et al, 2008). Studies (Zhang et al, 2008) find that, the percentage of IL-17 cells in peripheral blood of gastric cancer patients increases, compared with normal patients. The increase degree is related to clinical staging of gastric cancer.…”

Section: Discussionmentioning

confidence: 97%

CD4⁺, IL17 and Foxp3 Expression in Different pTNM Stages of Operable Non-small Cell Lung Cancer and Effects on Disease Prognosis

Zhang¹,

Han²,

Fang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 97%

CD4⁺, IL17 and Foxp3 Expression in Different pTNM Stages of Operable Non-small Cell Lung Cancer and Effects on Disease Prognosis

Zhang¹,

Han²,

Fang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…It remains controversial whether Il-17 promotes or inhibits cancer progression. In humans, Il-17 expression has been reported in several tumor tissues such as ovarian cancer, colon cancer and also gastric cancer (14)(15)(16). Most solid tumors contain non-malignant cells, including immune cells and blood vessel cells, which are important in inflammation in the tumor microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric cancer

Iida

Itō

Katsuda³

et al. 2011

Oncol Rep

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Abstract. recently, a subset of Il-17 producing t cells distinct from th1 or th2 cells has been described as key players in inflammation and autoimmune diseases as well as cancer development. In this study, we investigated the expression level of Il-17 and t helper 17 (th17)-related cytokines in gastric cancer tissues and assessed the association of their expression with angiogenesis and their clinicopathological parameters. tumor and adjacent normal tissues were obtained from 82 patients with gastric cancer. Il-17, Il-21 and Il-23 mRNA expression levels were quantified by real-time RT-PCR. Th17 infiltration, microvessel density and neutrophil infiltration in tumor tissues were examined by immunohistochemistry and double immunofluorescence histochemistry. Expression of IL-17, IL-21 and IL-23 mRNA was found to be significantly up-regulated in tumor tissues compared with adjacent normal tissues. the expression level of Il-17 mrnA strongly and positively correlated with that of Il-21 mrnA in tumor tissue. the number of vascular endothelial cells and infiltrating neutrophils was significantly larger in tumors expressing a high level of Il-17 mrnA than in tumors expressing a low level of Il-17 mrnA. In tumor tissues most cD4 + cells were stained with anti-Il-17 antibody. the expression level of Il-17 mrnA in gastric tumors was associated with the depth of the tumors, lymph-vascular invasion and lymph node involvement, suggesting that Il-17 obviously was related to tumor progression. Il-17 and Il-21, which regulates Il-17, would be potential therapeutic targets for the treatment of gastric cancer.

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“…While none of the healthy controls and only one meningioma and one schwannoma patient had IL-17A in their sera, elevation of this cytokine was confined to glioma patients. Previous studies have indicated an increase in the expression of IL-17A, as well as recruitment of Th17 cells to the site of gastric tumors (Zhang et al, 2008). In a recent study, we observed elevated levels of IL-17A in bladder cancer patients in southern Iranian patients (Doroudchi et al, 2013).…”

Section: Discussionmentioning

confidence: 50%

“…This expression was shown to be accompanied by IL-6, IFN-g , and IL-1β without significant differences between grades of glioma (Hu et al, 2011). Interestingly, IL-6, G-CSF, and TNF-a are among the genes that are induced by IL-17 (Kryczek et al, 2007;Miyahara et al, 2008;Sfanos et al, 2008;Zhang et al, 2008). In a cohort of primary brain tumors, an imbalance in the systemic IL-12/IL-10 balance as hallmarks of Th1/Th2 cytokine production has been shown.…”

Section: Introductionmentioning

confidence: 98%

Elevated Serum IL-17A but not IL-6 in Glioma Versus Meningioma and Schwannoma

Doroudchi

Pishe²,

Malekzadeh³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Background: There is a Th1/Th2 cytokine imbalance and expression of IL-17 in patients with brain tumours. We aimed to compare the levels of IL-17A and IL-6 in sera of glioma, meningioma and schwannoma patients as well as in healthy individuals. Materials and Methods: IL-17A and IL-6 levels were measured in sera of 38 glioma, 24 meningioma and 18 schwannoma patients for comparison with 26 healthy controls by commercial ELISA assays. Results: We observed an increase in the IL-17A in 30% of glioma patients while only 4% and 5.5% of meningioma and schwannoma patients and none of the healthy controls showed elevated IL-17A in their sera (0.29±0.54, 0.03±0.15 and 0.16±0.68 vs. 0.00±0.00pg/ml; p=0.01, p=0.01 and p=0.001, respectively). There was also a significant decrease in the level of IL-6 in glioma patients compared to healthy controls (2.34±4.35 vs. 4.67±4.32pg/ml; p=0.01). There was a direct correlation between the level of IL-17A and age in glioma patients (p=0.005). Glioma patients over 30 years of age had higher IL-17A and lower IL-6 in their sera compared to the young patients. In addition, a non-significant grade-specific inverse trend between IL-17A and IL-6 was observed in glioma patients, where high-grade gliomas had higher IL-17A and lower IL-6. Conclusions: Our data suggest a Th17 mediated inflammatory response in the pathogenesis of glioma. Moreover, tuning of IL-6 and IL-17A inflammatory cytokines occurs during progression of glioma. IL-17A may be a potential biomarker and/or immunotherapeutic target in glioma cases.

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The prevalence of Th17 cells in patients with gastric cancer

Cited by 236 publications

References 31 publications

CD4⁺, IL17 and Foxp3 Expression in Different pTNM Stages of Operable Non-small Cell Lung Cancer and Effects on Disease Prognosis

CD4⁺, IL17 and Foxp3 Expression in Different pTNM Stages of Operable Non-small Cell Lung Cancer and Effects on Disease Prognosis

Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric cancer

Elevated Serum IL-17A but not IL-6 in Glioma Versus Meningioma and Schwannoma

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The prevalence of Th17 cells in patients with gastric cancer

Cited by 236 publications

References 31 publications

CD4+, IL17 and Foxp3 Expression in Different pTNM Stages of Operable Non-small Cell Lung Cancer and Effects on Disease Prognosis

CD4+, IL17 and Foxp3 Expression in Different pTNM Stages of Operable Non-small Cell Lung Cancer and Effects on Disease Prognosis

Tumor-infiltrating CD4+ Th17 cells produce IL-17 in tumor microenvironment and promote tumor progression in human gastric cancer

Elevated Serum IL-17A but not IL-6 in Glioma Versus Meningioma and Schwannoma

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Product

Resources

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CD4⁺, IL17 and Foxp3 Expression in Different pTNM Stages of Operable Non-small Cell Lung Cancer and Effects on Disease Prognosis

CD4⁺, IL17 and Foxp3 Expression in Different pTNM Stages of Operable Non-small Cell Lung Cancer and Effects on Disease Prognosis