The prevalence of squamous cell carcinoma in different sites of oral cavity at our Rural Health Care Centre in Loni, Maharashtra – a retrospective 10-year study

Abstract

Aim of the studyOral cancer ranks in the top three of all cancers in India and is quickly becoming a global health priority. More than 90% of oral and oropharyngeal cancers are squamous cell carcinoma. The purpose of this study was to document its incidence depending upon the involvement of different sites of oral cavity, and its variation with age and gender.Material and methodsHistopathologically proven oral squamous cell carcinoma cases were collected from the department of oral and maxillofacial surgery RDC, PIMS. The cases were systematically grouped under three headings: anatomical sub-site of oral cavity, age group, and gender, which were analysed to calculate the prevalence of oral cancer. The study was undertaken after obtaining approval from the institutional Ethical Committee board.ResultsAmong the different sites of oral cavity, the highest incidence (31.47%) of oral squamous cell carcinoma was seen for buccal mucosa in our study. The most affected age group (39.50%) were patients above 50 years old, predominantly involving males.ConclusionsThe population in this study were mostly from remote areas, among which a high rate of occurrence of oral cancer was encountered because the people were of low socio-economic class, had a casual attitude towards their health, high rate of tobacco consumption, and limited health care facilities. This study provides valuable data of the prevalence of oral cancer among the rural population.

Smoking History Decreases Survival in Patients with Squamous Cell Carcinoma of the Mouth: A Retrospective Study with 15 Years of Follow-up

“…Concerning the age group, the majority of patients in the cohort were up to 65 years of age, which is similar to the demographic of patients in previous studies, showing that the typical oral cancer patients are predominantly men around the fifth and sixth decades of life (Mendez et al, 2012;Santos et al, 2010;Tandon et al, 2017). Furthermore, there is also an association seen in this study that directly relates tobacco history and alcohol intake (Durazzo et al, 2005).…”

Immunohistochemical Expression of TLR-4 and Its Correlation to Various Grades of Oral Squamous Cell Carcinoma

“…On the other hand, Effiom et al (21) found that most of the examined OSCC cases were presented in the mandibular and maxillary alveolar ridge followed by the tongue. Moreover, Tandon et al (22) have stated that the buccal mucosa is the most prevalent location for OSCC. This was attributed to the well-known habits of areca nut-and tobacco-chewing.…”

Claudin-1, A Double-Edged Sword in Cancer

“…Almost 90% of all oral carcinomas are oral squamous cell carcinomas (OSCC) [128]. It has been shown previously that the invasive activity of OSCC cells is enhanced by CLDN-1 through activation of MMP-1 and 2, resulting in increased cleavage of Laminin-5 γ2 chains.…”