The prevalence of <scp>NAFLD</scp> and <scp>NASH</scp> among patients with psoriasis in a tertiary care dermatology and rheumatology clinic

Roberts, K.; Cochet, Allyson; Lamb, Paul B.; Brown, Peter; Battafarano, Daniel F.; Brunt, Elizabeth M.; Harrison, Stephen A.

doi:10.1111/apt.13042

Cited by 69 publications

(74 citation statements)

References 18 publications

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“…the prevalence rate of NAFLD is more than 2.5-fold higher. It should be noted that we do not feel the results of our study discredit the possibility of NAFLD prevalence among psoriasis as determined in other studies conducted in Italy, Netherland, and the USA, which demonstrated that the prevalence was 46%, 47%, and 47%, respectively [22–24]. …”

Section: Discussioncontrasting

confidence: 60%

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Relationship between psoriasis and non-alcoholic fatty liver disease

Narayanasamy

Sanmarkan

Rajendran

et al. 2016

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IntroductionVarious components of metabolic syndrome have an important role in the pathogenesis of both non-alcoholic fatty liver disease (NAFLD) and psoriasis, suggesting an association between these diseases. However, at present very few studies have reported on the systematic evaluations of the prevalence of NAFLD in patients with psoriasis disorder.AimTo investigate the prevalence of NAFLD in patients with psoriasis vulgaris. The study also evaluated the parallel relationship between both of the diseases.Material and methodsPatients over18 years old and with a diagnosis of psoriasis vulgaris at the outpatient unit of Department of Dermatology were considered for enrolment and were followed up by the Department of Hepatology, Madras Medical College. Each and every patient completed a questionnaire, underwent a thorough skin evaluation, and had a right upper quadrant ultrasound and fasting blood workup.ResultsTwo hundred and fifty patients were enrolled in the study. The participants were predominantly middle aged (mean: 44.74 ±11.989 years), overweight (average body mass index (BMI): 24.772 ±3.611 kg/m2), and male (68%, n = 170). The overall prevalence of NAFLD among psoriasis was 45.2%.ConclusionsNon-alcoholic fatty liver disease is highly prevalent among our cohort of patients with psoriasis, occurring in 45.2% of patients. Comorbidity of NAFLD is highly associated with psoriasis, which emphasises that both diseases may develop simultaneously. Health care providers should be mindful of this association since early evaluation and diagnosis of NAFLD in patients with psoriasis may play a vital role in alleviating the progression of liver disease.

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Section: Discussioncontrasting

confidence: 60%

“…Many studies showed that elderly patients are at increased risk of NAFLD with psoriasis even if the skin disease is mild or moderate and not requiring systemic therapy [24, 25]. But an important finding of our study showed that a high prevalence is observed even in middle-aged psoriatic populations; the mean age of patients was 44.02 years.…”

Section: Discussionmentioning

confidence: 49%

Relationship between psoriasis and non-alcoholic fatty liver disease

Narayanasamy

Sanmarkan

Rajendran

et al. 2016

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“…Moreover, extracutaneous inflammatory manifestations resulting from direct organ involvement by psoriatic inflammation have been reported, mostly but not exclusively in pustular variants, uveitis, aseptic osteomyelitis and cholangitis being the best identified. Liver test abnormalities (LTA) are a frequent finding in patients with psoriasis, with a prevalence of 24–31% across three main studies, in Italy, India and North America . These studies also highlighted the multiple etiological factors that may account for LTA in psoriasis patients, notably including non‐alcoholic fatty liver disease (NAFLD) .…”

Section: Introductionmentioning

confidence: 99%

Liver test abnormalities in patients admitted for severe psoriasis: prevalence and associated risk factors

Finet

Viguier

Chazouillères

et al. 2016

Acad Dermatol Venereol

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“…Patients with NAFLD and psoriasis may also be at an increased risk for severe liver fibrosis(99). In a small study of 109 clinic patients with psoriasis the overall prevalence of biopsy-proven NASH was 22%(100). Interestingly, the presence of NAFLD among patients with psoriasis may also be linked to psoriasis severity(99, 101).…”

Section: Introductionmentioning

confidence: 99%

Extrahepatic Manifestations of Nonalcoholic Fatty Liver Disease

VanWagner

Rinella

2016

Curr Hepatology Rep

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Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide with an increased prevalence of metabolic, macro- and microvascular complications. The primary causes of mortality in NAFLD are cardiovascular disease (CVD), malignancy and liver disease. NAFLD is a multisystem disease that affects a variety of extra-hepatic organ systems. The main focus of this review is to summarize the reported extra-hepatic associations, which include CVD, chronic kidney disease, obstructive sleep apnea, osteoporosis, psoriasis, colorectal cancer, iron overload and various endocrinopathies (e.g. type 2 diabetes mellitus, thyroid dysfunction, and polycystic ovarian syndrome). Due to the systemic manifestations of NAFLD patients require a multidisciplinary assessment and may benefit from more rigorous surveillance and early treatment interventions to decrease mortality related to malignancy or cardiometabolic diseases.

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The prevalence of NAFLD and NASH among patients with psoriasis in a tertiary care dermatology and rheumatology clinic

Cited by 69 publications

References 18 publications

Relationship between psoriasis and non-alcoholic fatty liver disease

Relationship between psoriasis and non-alcoholic fatty liver disease

Liver test abnormalities in patients admitted for severe psoriasis: prevalence and associated risk factors

Extrahepatic Manifestations of Nonalcoholic Fatty Liver Disease

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