“…Using medical vulnerability to severe COVID-19 outcomes, as defined using CDC criteria, 50 we estimated that during the BA.2/BA.2.12.1 surge in New York City, 8 SARS-CoV-2 prevalence among medically vulnerable adults was 2.5 times higher than other adults. However, during the BA.2/BA.2.12.1 surge, we also found that 50.6% of New York City adults had hybrid protection conferred from both vaccination and prior infection, compared with 30.9% who had vaccine-induced immunity only, 11.5% with infected-induced immunity only, and 7.0% with no immunity.…”