The prevalence of SARS-CoV-2 antibodies within the community of a private tertiary university in the Philippines: A serial cross sectional study

Sumpaico-Tanchanco, Lourdes Bernadette; Sy, Jenica Clarisse Y.; Dy, Angel Belle C.; Levantino, Myla; Amit, Arianna Maever L.; Wong, John Q.; Angeles, Kirsten; Vergara, John Paul C.

doi:10.1371/journal.pone.0268145

Cited by 2 publications

(1 citation statement)

References 46 publications

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“…The seroprevalence of the study population, which consisted of faculty, staff and students in a private tertiary university, ranged from 28.8% to 65.1%. The seropositive rate showed an increasing trend during the 7-month study period ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Durability and extent of protection of SARS-CoV-2 antibodies among patients with COVID-19 in Metro Manila, Philippines

Gonzales,

Dans,

Tan-Lim

et al. 2023

Front. Immunol.

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IntroductionInformation on the magnitude and durability of humoral immunity against COVID-19 among specific populations can guide policies on vaccination, return from isolation and physical distancing measures. The study determined the durability of SARS-CoV-2 antibodies after an initial infection among Filipinos in Metro Manila, Philippines, and the extent of protection SARS-CoV-2 antibodies confer against reinfection.MethodsWe conducted a cohort study to monitor the antibody levels of patients diagnosed with COVID-19. Receptor-binding domain (RBD)-specific antibodies were measured at Days 21, 90, 180, 270 and 360. Antibody levels were reported as geometric mean titers (GMT) with geometric standard deviation (GSD). Differences in GMT were tested using Friedman test and Kruskal Wallis test, with Bonferroni multiple comparisons procedure. Adjusted hazard ratios on the development of probable reinfection were estimated using Cox proportional models.ResultsThere were 307 study participants included in the study, with 13 dropouts. Study participants received SARS-CoV-2 vaccines at varying times, with 278 participants (90.5%) fully vaccinated by the end of study. The GMT of the study cohort increased over time, from 19.7 U/mL (GSD 11) at Day 21; to 284.5 U/mL (GSD 9.6) at Day 90; 1,061 U/mL (GSD 5.3) at Day 180; 2,003 U/mL (GSD 6.7) at Day 270; and 8,403 U/mL (GSD 3.1) at Day 360. The increase was statistically significant from Day 21 to Day 90 (p<0.0001), Day 90 to Day 180 (p=0.0005), and Day 270 to Day 360 (p<0.0001). Participants with more severe initial infection demonstrated significantly higher antibody levels compared to those with milder infection at Day 21. Sixty-four patients had probable COVID-19 reinfection (incidence of 20.8%, 95% CI 16.4, 25.8%). The GMT of these 64 patients was 411.8 U/mL (GSD 6.9) prior to the occurrence of the probable reinfection. Majority (87.5%) were fully vaccinated. Antibody titers significantly affected the risk of developing reinfection, with adjusted hazard ratio of 0.994, 95% CI 0.992-0.996, p<0.001.ConclusionAntibody levels against SARS-CoV-2 increased over a one-year follow-up. Higher antibody levels were observed among those with more severe initial infection and those vaccinated. Higher antibody levels are associated with a lower risk of probable reinfection.

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Section: Introductionmentioning

confidence: 99%

Durability and extent of protection of SARS-CoV-2 antibodies among patients with COVID-19 in Metro Manila, Philippines

Gonzales,

Dans,

Tan-Lim

et al. 2023

Front. Immunol.

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Whole campus wastewater surveillance of SARS-CoV-2 for COVID-19 outbreak management

Sharaby

Gilboa

Alfiya

et al. 2023

Water Science and Technology

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In this long-term study (8 months), a wastewater-based epidemiology program was initiated as a decision support tool for the detection and containment of COVID-19 spread in the Technion campus. The on-campus students' accommodations (∼3,300 residents) were divided into housing clusters and monitored through wastewater SARS-CoV-2 surveillance in 10 manholes. Results were used to create a ‘traffic-light’ scheme allowing the Technion's COVID-19 task force to track COVID-19 spatiotemporal spread on the campus, and consequently, contain it before high morbidity levels develop. Of the 523 raw sewage samples analysed, 87.4% were negative for SARS-CoV-2 while 11.5% were positive, corroborating morbidity information the COVID-19 task force had. For 7.6% of the SARS-CoV-2 positive samples, the task force had no information about positive resident/s. In these events, new cases were identified after the relevant residents were clinically surge tested for COVID-19. Hence, in these instances, wastewater surveillance provided early warning helping to secure the health of the campus residents by minimising the spread of COVID-19. The inflammation biomarker ferritin levels in SARS-CoV-2 positive sewage samples were significantly higher than in negative ones. This may indicate that in the future, ferritin (and other biomarkers) concentrations in wastewater could serve as indicators of infectious and inflammatory disease outbreaks.

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The prevalence of SARS-CoV-2 antibodies within the community of a private tertiary university in the Philippines: A serial cross sectional study

Cited by 2 publications

References 46 publications

Durability and extent of protection of SARS-CoV-2 antibodies among patients with COVID-19 in Metro Manila, Philippines

Durability and extent of protection of SARS-CoV-2 antibodies among patients with COVID-19 in Metro Manila, Philippines

Whole campus wastewater surveillance of SARS-CoV-2 for COVID-19 outbreak management

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