The prevalence of sarcopenic obesity and its association with cognitive performance in type 2 diabetes in Singapore

Low, Sui Pheng; Goh, Kiat Sern; Ng, Tze Pin; Ang, Su Fen; Moh, Angela; Wang, Jiexun; Ang, Keven; Tavintharan, Subramaniam; Sum, Chee Fang; Lim, Su Chi

doi:10.1016/j.clnu.2019.10.019

Cited by 41 publications

(33 citation statements)

References 51 publications

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“…It has satisfactory psychometric properties and has been validated in the different populations including Singapore . Our group has previously published observations from our cohort based on these assessment tools . Those who did not undergo RBANS and/or MMSE screening typically had younger age, shorter T2D duration, higher adiposity, poorer glycaemic and lipid control, reduced microvascular reactivity, and lower education (Table ).…”

Section: Methodsmentioning

confidence: 99%

Role of endothelium‐independent vasodilation in the relationship between visceral adiposity and reduced cognitive performance in older adults with type 2 diabetes

Moh

Low

et al. 2020

Microcirculation

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Objective: In this cross-sectional analysis, we sought to assess the relationship of adiposity and forearm microvascular reactivity with cognitive dysfunction among older Asians with type 2 diabetes (T2D). Methods: Subjects with T2D aged ≥ 55 years were analyzed (N = 907). Cognitive performance was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) and Mini-Mental State Exam (MMSE). Visceral fat area (VFA) was estimated by tetrapolar multi-frequency bioimpedance. Forearm microvascular endothelium-dependent vasodilation (EDV) and endothelium-independent vasodilation (EIV) were assessed by laser Doppler imaging with iontophoresis.Results: RBANS total score was correlated with VFA, EDV, and EIV (all P < .05).However, VFA was correlated with EIV, but not with EDV. Multivariable linear regression showed significant association between VFA and RBANS total score (B = −0.02, 95% CI= −0.03 to −0.01) or memory (immediate and delayed) index scores. These associations were attenuated after adjustment for EIV. Mediation analysis showed that EIV partially mediated the relationship between visceral adiposity and RBANS scores (all Sobel tests P < .05). EIV also mediated the relationship between VFA and MMSE score.Conclusions: Impaired endothelium-independent vascular smooth muscle reactivity may exert a mediatory effect on the association between increased visceral adiposity and decreased cognitive performance in older adults with T2D.

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Section: Methodsmentioning

confidence: 99%

Role of endothelium‐independent vasodilation in the relationship between visceral adiposity and reduced cognitive performance in older adults with type 2 diabetes

Moh

Low

et al. 2020

Microcirculation

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“…However, among the traditional anthropometric measures to diagnose sarcopenic obesity, a higher fat mass to fat-free mass (FM/FFM) ratio is considered as a valuable diagnostic criterion when BIA is used for measurement. Accordingly, FM/FFM ratio more than 0.80 was considered as a sarcopenic obesity (25).…”

Section: Diagnostic Measures For Sarcopenic Obesitymentioning

confidence: 99%

The Association Between TP53 rs1625895 Polymorphism and the Risk of Sarcopenic Obesity in Iranian Older Adults: A Case-Control Study

Montazeri-Najababady

Dabbaghmanesh

Nasimi

et al. 2020

Preprint

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Background: Aging and obesity are the two major global health concerns. Sarcopenia, an age-linked disease, wherein a progressive loss of muscle volume, muscle strength, and physical activity occurs. In this study we evaluated the association of TP53 rs1625895 polymorphism with the susceptibility to sarcopenic obesity in Iranian old-age subjects. Total of 206 old individuals (45 sarcopenic and 161 non-sarcopenic) were recruited in this research and genotyped by PCR–RFLP. BMI, Skeletal Muscle Mass Index (SMI), body composition, Handgrip Strength (HGS), Gait Speed (GS), and biochemical parameters were measured. Chi-square test was done for genotypes and alleles frequency. Linear regression was applied to find the correlation between TP53 rs1625895 polymorphism, and biochemical and anthropometric parameters. The correlation between TP53 rs1625895 and the risk of sarcopenia and sarcopenic obesity was investigated by logistic regression.Results: G allele was significantly higher in sarcopenic obesity group [P =0.037, OR (CI 95%)=1.9 (1.03-3.5)] compared to A allele. BMI (P= 0.049) and LDL (P=0.04) were significantly differed between genotypes when GG was compared to AA/AG genotype. The results revealed when GG genotype compared to AA/AG genotype in adjusted model for age, the risk of sarcopenic obesity [P value= 0.011, OR (CI 95%); 2.72 (1.25-5.91)] increased. Similarly, GG/AG genotype increased the risk of sarcopenic obesity [P value= 0.028, OR (CI 95%); 2.43 (1.10-5.36)] in adjusted model for age compared to AA genotype.Conclusion: We concluded that TP53 rs1625895 polymorphism may increase the risk of sarcopenic obesity in Iranian population.

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“…The exclusion criteria were previously described. 12 Data collected up to October 2017 were analysed ( Figure 1). The final analysed cohort (N = 677) constituted older subjects aged ≥60 years (age range: 60-86 years).…”

Section: Introductionmentioning

confidence: 99%

Association of traditional and novel measures of central obesity with cognitive performance in older multi‐ethnic Asians with type 2 diabetes

Moh

Low

et al. 2020

Clinical Obesity

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Summary Literature evaluating the relationship between central obesity and cognitive deficits in type 2 diabetes (T2DM) remains scarce. This cross‐sectional analysis explored the association of novel and traditional central obesity measures with cognitive performance in older (aged ≥60 years) non‐demented multi‐ethnic Asians with T2DM, including a stratified analysis by body mass index (BMI). Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status. Central obesity measures including visceral fat area (VFA), waist circumference, waist:hip ratio, waist:height ratio, abdominal volume index, body roundness index and conicity index were measured and/or computed. In our cohort (N = 677; mean age = 67 ± 5 years, 51.7% men), VFA emerged as an associate of overall cognitive performance after covariate adjustment and Bonferroni correction (β = −.10, 95% CI = −0.18, −0.03), outperforming the other adiposity indices. Specifically, VFA was inversely associated with delayed memory and language scores. Additionally, compared with normal‐weight individuals, excess visceral obesity (VFA ≥100 cm2) was independently associated with lower cognitive scores to a greater extent in normal BMI (<23 kg/m2) adults than in those with high BMI (≥23 kg/m2). Assessment and management of visceral adiposity may help to prevent cognitive decline in older people with T2DM, and reduce the global burden of dementia in ageing populations.

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The prevalence of sarcopenic obesity and its association with cognitive performance in type 2 diabetes in Singapore

Cited by 41 publications

References 51 publications

Role of endothelium‐independent vasodilation in the relationship between visceral adiposity and reduced cognitive performance in older adults with type 2 diabetes

Role of endothelium‐independent vasodilation in the relationship between visceral adiposity and reduced cognitive performance in older adults with type 2 diabetes

The Association Between TP53 rs1625895 Polymorphism and the Risk of Sarcopenic Obesity in Iranian Older Adults: A Case-Control Study

Association of traditional and novel measures of central obesity with cognitive performance in older multi‐ethnic Asians with type 2 diabetes

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