The prevalence of restless legs syndrome in patients undergoing coronary angiography and its relationship with the severity of coronary artery stenosis

Aksoy, Dürdane; Çelik, Ataç; Solmaz, Volkan; Çevik, Betül; Sümbül, Orhan; Kurt, Semiha

doi:10.1007/s11325-020-02085-2

Cited by 2 publications

(3 citation statements)

References 27 publications

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“…To our knowledge, this is the rst study investigating the relationship between RLS and CFVR. Indeed, in some recent studies, it was demonstrated that there is a link between RLS and CHD [14,7]. However, the correlation between CFVR and the severity of RLS has not been directly evaluated before.…”

Section: Discussionmentioning

confidence: 99%

“…This produced a total scale whose overall score could range from 0 to 40. Patients were classi ed into four groups with scores of mild (0-10), moderate (11)(12)(13)(14)(15)(16)(17)(18)(19)(20), severe (21)(22)(23)(24)(25)(26)(27)(28)(29)(30), and very severe (31-40) RLS according to this scale. Age and sex-matched healthy controls (n = 58) were selected from patients with normal coronary arteries with similar age and gender distribution to the RLS patients (Group HC).…”

Section: Methodsmentioning

confidence: 99%

“…The IRLS was used to evaluate the severity of RLS. Patients were classi ed into four groups with scores of mild (0-10), moderate (11)(12)(13)(14)(15)(16)(17)(18)(19)(20), severe (21)(22)(23)(24)(25)(26)(27)(28)(29)(30), and very severe (31-40) RLS. The area under the receiver operating characteristic (ROC) curve (AUC) along with its 95% con dence interval (CI) was given to assess the diagnostic value of CRVF, WBC, and CRP to discriminate between mild, moderate, severe, and very severe RLS.…”

Section: Statistical Analysesmentioning

confidence: 99%

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Coronary Flow Velocity Reserve is Decreased in Patients with Restless Leg Syndrome

Güz

Demirgan

2022

Preprint

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IntroductionIn this study, we aimed to evaluate coronary endothelial dysfunction in restless legs syndrome(RLS) patients using coronary flow velocity reserve(CFVR) and compared it with healthy controls.MethodIn this study, the participants were divided into two groups as group RLS(n=42) and group HC(n=41). The primary outcome was the CFVR compared between groups. The number of participants with a CFVR value below 2.0 was also evaluated. In addition, a correlation between the international restless legs scale(IRLS) and CFVR, white-blood-cell-count(WBC), C-reactive-protein(CRP) were analyzed. Secondary outcomes were the WBC, hemoglobin, CRP, blood glucose, high-density-lipoprotein(HDL), low-density-lipoprotein(LDL), and creatinine compared between the two groups.ResultsA total of 116 participants were recruited for this study, and 83 participants(42 in Group RLS and 41 in Group HC) were ultimately enrolled. In the group RLS, CFVR was measured lower than healthy controls(p<0.001). When the groups were compared in terms of the number of participants with a CFVR less than 2.0, the difference between the groups was significant(p<0.001, 0/41 in group HC and 14/42 in group RLS).Patients with RLS had higher WBC and CRP values. There was a negative correlation between CFVR and IRLS(p<0.001). The relationship between WBC, CRP, and IRLS was not statistically significant(p=0.691).Discussion/ConclusionWe conclude that RLS patients had lower CFVR compared with healthy controls and there was a negative correlation between the severity of RLS and CFVR which indicates coronary endothelial function. Therefore, we think that it may be beneficial to follow up patients with RLS in terms of coronary heart disease.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Statistical Analysesmentioning

confidence: 99%

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Coronary Flow Velocity Reserve is Decreased in Patients with Restless Leg Syndrome

Güz

Demirgan

2022

Preprint

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Coronary Flow Velocity Reserve is Decreased in Patients with Restless Leg Syndrome; Case Control Study

Güz,

Demirgan

2024

Preprint

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Background Restless leg syndrome (RLS) has been associated with an increased risk of vascular disorders, which suggests that endothelial dysfunction plays important role in the pathogenesis of RLS. In this study, we aimed to evaluate coronary endothelial dysfunction in RLS patients using coronary flow velocity reserve (CFVR) and compared it with healthy controls. Methods In this study, the participants were divided into two groups as group RLS (n=42) and group HC (n=41). The primary outcome was the CFVR compared between groups. The number of participants with a CFVR value below 2.0 was also evaluated. In addition, a correlation between the international restless legs scale (IRLS) and CFVR, white-blood-cell-count (WBC), C-reactive-protein (CRP) were analyzed. Secondary outcomes were the WBC, hemoglobin, CRP, blood glucose, high-density-lipoprotein (HDL), low-density-lipoprotein (LDL), and creatinine compared between the two groups. Results In the group RLS, CFVR was measured lower than healthy controls (p<0.001). When the groups were compared in terms of the number of participants with a CFVR less than 2.0, the difference between the groups was significant (p<0.001, 0/41 in group HC and 14/42 in group RLS). Patients with RLS had higher WBC and CRP values. There was a negative correlation between CFVR and IRLS (p<0.001). The relationship between WBC, CRP, and IRLS was not statistically significant (p=0.691). Conclusions We conclude that RLS patients had lower CFVR compared with healthy controls and there was a negative correlation between the severity of RLS and CFVR. Therefore, we think that it may be beneficial to follow up patients with RLS in terms of coronary heart disease.

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The prevalence of restless legs syndrome in patients undergoing coronary angiography and its relationship with the severity of coronary artery stenosis

Cited by 2 publications

References 27 publications

Coronary Flow Velocity Reserve is Decreased in Patients with Restless Leg Syndrome

Coronary Flow Velocity Reserve is Decreased in Patients with Restless Leg Syndrome

Coronary Flow Velocity Reserve is Decreased in Patients with Restless Leg Syndrome; Case Control Study

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