The prevalence of restless legs syndrome (RLS) in patients with multiple sclerosis (MS): a systematic review and meta-analysis—an update

Zali, Alireza; Motavaf, Mahsa; Safari, Saeid; Ebrahimi, Narges; Ghajarzadeh, Mahsa; Khoshnood, Reza Jalili; Mirmosayyeb, Omid

doi:10.1007/s10072-022-06364-6

Cited by 5 publications

(4 citation statements)

References 60 publications

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“…RLS could be an etiological factor for other sleep disorders such as insomnia, and reduced sleep quality may lead to excessive daytime sleepiness and mood disorders. [ 4 , 24 , 26 , 27 ] However, our patient population had no significant daytime sleepiness related to poor sleep; patients with RLS symptoms more frequently experienced sleep disorders, fatigue, and depression. We saw that this result is consistent with the study by Seferoğlu et al .…”

Section: Discussionmentioning

confidence: 79%

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Initial Cervical Spinal Cord Demyelinating Lesions are not Associated with Restless Legs Syndrome in Patients with Multiple Sclerosis

Eşkut

Köşkderelioğlu

Gedizlioğlu³

et al. 2023

Annals of Indian Academy of Neurology

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Purpose: This study aims to determine the prevalence and severity of restless legs syndrome (RLS) in patients with multiple sclerosis (MS) and its association with spinal cord lesions, fatigue, quality of life, and sleep disturbance. Methods: We recruited 222 consecutive MS patients admitted to MS outpatient clinic. Beck’s Depression Inventory (BDI), Fatigue Severity Scale (FSS), Epworth Sleepiness Scale (ESS), Pittsburgh Sleep Quality Index (PSQI), and MS Quality of Life-54 (MSQoL-54) questionnaire scores of all patients were measured. Initial cervical spinal cord magnetic resonance imaging (MRI) of the patients at first clinical evaluation for diagnosis was reviewed for accompanying demyelinating lesions. Results: RLS was diagnosed in 53 (23.87%) patients. RLS was associated with poor sleep, worse quality of life, increased fatigue, and depressive mood. The sleep quality index, FSS, and MSQoL-54 physical composite scores significantly correlated with RLS severity (P < 0.001, P = 0.001, P < 0.001, respectively). Of the 200 patients, 127 (63.5%) had spinal cord lesions. 22.83% of the patients with cervical spinal cord lesions had RLS comorbidity. We found no significant difference regarding spinal cord demyelinating lesions between RLS positives and negatives. (P = 0.77). In addition, having multiple spinal cord demyelinating lesions did not differ between the two groups (P = 0.84). Besides, the severity of RLS symptoms did not differ in patients who had a single cervical spinal lesion and those who had multiple lesions (P = 0.35). Conclusion: We have demonstrated the negative impact of comorbid RLS on fatigue, sleep quality, mood, and quality of life in MS patients. However, initial spinal cord lesions did not correlate with RLS comorbidity. The severity of RLS symptoms is associated with poor sleep and physical health.

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Section: Discussionmentioning

confidence: 79%

“…[ 9 ] used face-to-face interviews and reported the prevalence of RLS in their MS population at 20%. Recently, in a meta-analyze study, conducted by Zali et al [ 26 ] showed the pooled prevalence of RLS in PwMS was estimated as 28%, while the pooled prevalence in control group was estimated as 8%. Similarly, 23.87% of our PwMS had RLS.…”

Section: Discussionmentioning

confidence: 99%

Initial Cervical Spinal Cord Demyelinating Lesions are not Associated with Restless Legs Syndrome in Patients with Multiple Sclerosis

Eşkut

Köşkderelioğlu

Gedizlioğlu³

et al. 2023

Annals of Indian Academy of Neurology

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“…In this regard, the proteins encoded by LAG3/CD4 genes play an important role in inflammatory and immune responses. As previously commented, at least one SNV in these genes has been related to the risk for multiple sclerosis [ 32 ], a paradigm of inflammatory and neurodegenerative disease, which is frequently associated with secondary RLS [ 38 ]. Moreover, two recent studies have shown an association of two SNVs in the LAG3/CD4 genes with the risk for PD [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

LAG3/CD4 Genes Variants and the Risk for Restless Legs Syndrome

Jiménez‐Jiménez

Gómez-Tabales

Alonso‐Navarro

et al. 2022

IJMS

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According to several studies, inflammatory factors could be related to the pathogenesis of idiopathic restless legs syndrome (RLS). In addition, RLS and Parkinson’s disease (PD) have shown a possible relationship, and recent studies have shown an association between CD4 rs1922452 and CD4 rs951818 single nucleotide variants (SNVs) and the risk for PD. For these reasons, we investigated the possible association between common variants in the LAG3/CD4 genes (which encoded proteins involved in inflammatory and autoimmune responses) and the risk for RLS in a Caucasian Spanish population. We assessed the frequencies of CD4 rs1922452, CD4 rs951818, and LAG3 rs870849 genotypes and allelic variants in 285 patients with idiopathic RLS and 350 healthy controls using a specific TaqMan-based qPCR assay. We also analyzed the possible influence of the genotypes’ frequencies on several variables, including age at onset of RLS, gender, family history of RLS, and response to drugs commonly used in the treatment of RLS. We found a lack of association between the frequencies of genotypes and allelic variants of the 3 SNVs studied and the risk of RLS, and a weak though significant association between the CD4 rs1922452 GG genotype and an older age at onset of RLS. With the exception of this association, our findings suggest that common SNVs in the CD4/LAG3 genes are not associated with the risk of developing idiopathic RLS in Caucasian Spanish people.

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“…There have been several studies that have explored the association between RLS and various health issues such as hypothyroidism, multiple sclerosis, diabetes mellitus, and polycystic ovarian syndrome [8][9][10][11]. However, only two studies have investigated the association between RLS and endometriosis.…”

mentioning

confidence: 99%

The Correlation of Restless Leg Syndrome with Endometriosis: A Cross-Sectional Study

Taha

2024

amj

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The prevalence of restless legs syndrome (RLS) in patients with multiple sclerosis (MS): a systematic review and meta-analysis—an update

Cited by 5 publications

References 60 publications

Initial Cervical Spinal Cord Demyelinating Lesions are not Associated with Restless Legs Syndrome in Patients with Multiple Sclerosis

Initial Cervical Spinal Cord Demyelinating Lesions are not Associated with Restless Legs Syndrome in Patients with Multiple Sclerosis

LAG3/CD4 Genes Variants and the Risk for Restless Legs Syndrome

The Correlation of Restless Leg Syndrome with Endometriosis: A Cross-Sectional Study

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