The prevalence of pulmonary fibrosis combined with emphysema in patients with lung cancer

Usui, Kazuhiro; Tanai, Chiharu; Tanaka, Yoshiaki; Noda, Hiromichi; Ishihara, Teruo

doi:10.1111/j.1440-1843.2010.01907.x

Cited by 139 publications

(143 citation statements)

References 21 publications

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“…First, the number of patients included was small, although the study populations are homogeneous in terms of histology, stage, and treatment. Second, we did not evaluate the prognostic significance of CPFE due to small number of patients (n=7), although a previous report showed patients with CPFE showed poor prognosis than those with emphysema only (28). Furthermore, we cannot analyze the value of the emphysema distribution (i.e., one area with >75% emphysema vs. diffuse emphysema across multiple regions) because no patient had localized emphysema.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of CT-emphysema score in patients with advanced squamous cell lung cancer

Kim

Ahn

et al. 2016

J. Thorac. Dis.

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IntroductionChronic obstructive pulmonary disease (COPD) and lung cancer present major medical challenges; COPD is the third leading cause of death and lung cancer is the leading cause of cancer-related death in the United States (1,2). Several studies have established a relationship between COPD and lung cancer. The prevalence of COPD in newly-diagnosed lung cancer patients was estimated at about 50% (3) and COPD is considered an independent risk factor of lung cancer, irrespective of smoking history (4,5).Emphysema, one of the classic subtypes of COPD, is characterized by abnormal and permanent enlargement of airspaces distal to terminal bronchioles and accompanying destruction of alveolar walls. Computed tomography (CT) is an established method for the detection and quantification of emphysema (6,7), and CT-diagnosed emphysema has also been reported to be associated with an increased risk of lung cancer independently of smoking history and airflow obstruction (8). Furthermore, recent studies have reported that presence of emphysema detected by CT in resected Original Article

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Section: Discussionmentioning

confidence: 99%

Prognostic significance of CT-emphysema score in patients with advanced squamous cell lung cancer

Kim

Ahn

et al. 2016

J. Thorac. Dis.

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“…The patients' clinical characteristics were consistent with those previously reported. 1,[7][8][9][10][11][12][13] A PFT analysis was also performed. In this study, the baseline ventilatory capacity characteristics of the CPFE group were similar to those described by others, 7,8,10,14) in that lung volumes were well preserved, and FEV1% appeared normal.…”

Section: Discussionmentioning

confidence: 99%

Surgical Outcomes of Lung Cancer Patients with Combined Pulmonary Fibrosis and Emphysema and Those with Idiopathic Pulmonary Fibrosis without Emphysema

Sato

Koike

Hashimoto

et al. 2016

ATCS

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“…CPFE has a poor prognosis, with a 5-year survival of 55% [4]. CPFE may be found in patients presenting with lung cancer, and cancer may develop in patients followed for CPFE, probably reflecting similarities in the susceptibility to chronic smoking-induced inflammation and carcinogenesis [11,12].…”

Section: Disease Characteristicsmentioning

confidence: 99%

The impact of emphysema in pulmonary fibrosis

Cottin¹

2013

European Respiratory Review

130

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Several groups have described a syndrome in which idiopathic pulmonary fibrosis (IPF) coexists with pulmonary emphysema. This comes as no surprise since both diseases are associated with a history of exposure to cigarette smoke. The syndrome of combined pulmonary fibrosis and emphysema (CPFE) is characterised by upper lobe emphysema and lower lobe fibrosis. Physiological testing of these patients reveals preserved lung volume indices contrasted by markedly impaired diffusion capacity. The incidence of CPFE remains unknown but several case series suggest that this subgroup may comprise up to 35% of patients with IPF. CPFE is a strong determinant of associated pulmonary hypertension (PH). In addition, CPFE has major effects on measures of physiological function, exercise capacity and prognosis, and may affect the results of pulmonary fibrosis trials. Further studies are needed to ascertain the aetiology, morbidity, mortality and management of the CPFE syndrome, with or without PH, and to evaluate novel therapeutic options in CPFE.

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The prevalence of pulmonary fibrosis combined with emphysema in patients with lung cancer

Abstract: CPFE is more prevalent than fibrosis in patients with lung cancer, and patients with CPFE had a poorer prognosis in the present study. Further investigation is therefore necessary to elucidate whether CPFE is an independent risk factor for lung cancer.

Cited by 139 publications

References 21 publications

Prognostic significance of CT-emphysema score in patients with advanced squamous cell lung cancer

Prognostic significance of CT-emphysema score in patients with advanced squamous cell lung cancer

Surgical Outcomes of Lung Cancer Patients with Combined Pulmonary Fibrosis and Emphysema and Those with Idiopathic Pulmonary Fibrosis without Emphysema

The impact of emphysema in pulmonary fibrosis

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