The prevalence of psychopathology in offspring of bipolar women from a Brazilian tertiary center

Benetti, Sílvia Pereira da Cruz; Gutt, Elisa Kijner; Krelling, Renata; Neto, Francisco Lotufo; Rohde, Luís Augusto; Moreno, Ricardo Alberto

doi:10.1590/s1516-44462009000300009

Cited by 26 publications

(44 citation statements)

References 34 publications

(35 reference statements)

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“…16 Petresco and colleagues demonstrated that the offspring of bipolar mothers had higher prevalence of ADHD (11.6%) compared to the offspring of control mothers (4.7%). 17 We also found high rates of ADHD in offspring of parents with BP and offspring with BP in the Pittsburgh Bipolar Offspring Study (BIOS). 13,18 However, these studies were limited by one or more of the following limitations: lack of longitudinal prospective evaluation of the ADHD symptomatology, small sample sizes, not taking into account the effects of several factors that may have affected the outcome (e.g., socioeconomic status, pubertal status, and children’s comorbid disorders), and control groups consisting of offspring of healthy parents only.…”

Section: Introductionmentioning

confidence: 70%

Longitudinal Trajectories of ADHD Symptomatology in Offspring of Parents With Bipolar Disorder and Community Controls

Kim

Yu²,

Ryan³

et al. 2015

J. Clin. Psychiatry

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Objective To compare the psychopathology and longitudinal course of attention deficit hyperactivity disorder (ADHD) symptomatology and global functioning between the offspring with ADHD of bipolar disorder (BP) parents and the offspring with ADHD of community control parents. Method One-hundred and twenty-two offspring with ADHD of BP parents and 48 offspring with ADHD of control parents from the Pittsburgh Bipolar Offspring Study (BIOS) were included. DSM-IV lifetime psychiatric disorders were ascertained through the K-SADS-PL. The outcome measures of ADHD symptoms were ascertained at intake and every other year for a period of 6 years using the ADHD section of the K-SADS-PL and the Disruptive Behavior Disorder rating scale (DBD). Global functioning was assessed using the Children’s Global Assessment Scale (CGAS). Results The offspring with ADHD of BP parents showed higher lifetime prevalence of mood and anxiety disorders relative to the offspring with ADHD of control parents (p-values ≤0.05). For both groups of offspring with ADHD, the hyperactivity, impulsivity, and total K-SADS-PL ADHD scores decreased over time (p-values <0.001) without differences between the two groups. There were no between- or within-group differences in the inattention scores over time. The DBD ADHD scores decreased with age in both groups (p-values <0.002) without differences between the two groups. For both groups of offspring with ADHD, the global functioning did not improve over time. Conclusion ADHD in offspring of BP parents have more psychopathology relative to offspring with ADHD of control parents. However, there were no differences in the developmental courses of ADHD symptomatology between these two groups of ADHD youth.

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Section: Introductionmentioning

confidence: 70%

Longitudinal Trajectories of ADHD Symptomatology in Offspring of Parents With Bipolar Disorder and Community Controls

Kim

Yu²,

Ryan³

et al. 2015

J. Clin. Psychiatry

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“…In adults, the rates are around 5 to 10%, suggesting a larger genetic component in the early-onset form of BD. [42][43][44] In naturalistic studies of BD among children and adolescents, the recovery rates are high (70 to 100%), but the recurrence rate in 2 to 5 years is up to 80%. [45][46][47] Moreover, most of the time these patients experienced subsyndromal and syndromal mood symptomatology and frequent mood fluctuations, as reported in the Course and Outcome of Bipolar Youth (COBY, n=263) 2-year followup study.…”

Section: Epidemiologymentioning

confidence: 99%

Mood disorders in childhood and adolescence

Rocha

Zeni

Caetano

et al. 2013

Rev. Bras. Psiquiatr.

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The identification and treatment of mood disorders in children and adolescents has grown over the last decades. Major depression is one of the most common and debilitating disorders worldwide, imposing a massive burden to the youth population. Bipolar disorder is being increasingly recognized as having its roots early in life, and its presentation during childhood and adolescence has been submitted to extensive research. This review aims to highlight clinical aspects of the current knowledge on mood disorders in the pediatric population, presenting updated information on epidemiology, diagnostic procedures, and management strategies. Limitations of available evidence and future directions of research in the field are also discussed.

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“…An important consideration is whether the reviewed studies are developmentally informative, with regard to (i) what developmental patterns of DRT are evident in O‐BD and (ii) whether these perturbations of early development portend impaired functioning for O‐BD compared to low‐ or high‐risk groups. Although many of the dimensional studies were cross‐sectional and included a wide range of ages (e.g., , , ), making it difficult to characterize DRT in specific developmental periods, an imperative consideration also is the developmental window being assessed. Ideally, elevations in DRT should be examined at developmentally relevant assessment points, such as during age‐salient developmental tasks, developmental transitions or points in development when pathological conditions associated with DRT emerge .…”

Section: Resultsmentioning

confidence: 99%

“…The most consistently used dimensional approach, utilized by eight of the studies listed in Table to evaluate DRT, was to examine raw or T ‐scores from the Thought Problems (TP) scale from the CBCL, Youth Self‐Report (YSR), Young Adult Self‐Report (YASR), Young Adult Behavior Checklist (YABCL), and Teacher‐Report Form (TRF) . The Achenbach scales are empirically derived from factor analytic techniques and have demonstrated sound internal consistency and test–retest reliability (e.g., r = 0.74 over a two‐week interval) .…”

Section: Methodsmentioning

confidence: 99%

Disturbances in reality testing as markers of risk in offspring of parents with bipolar disorder: a systematic review from a developmental psychopathology perspective

et al. 2013

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Objectives This comprehensive review examined the prevalence and progression of disturbances in reality testing (DRT), defined as psychotic symptoms, cognitive disruptions, and thought problems, in offspring of parents with bipolar disorder (O-BD). Our approach was grounded in a developmental psychopathology perspective and considered a broader phenotype of risk within the bipolar–schizophrenia spectrum as measured by categorical and dimensional assessments of DRT in high-risk youth. Methods Relevant studies were identified from numerous sources (e.g., PubMed, reference sections, and colleagues). Inclusion criteria were: (i) family risk studies published between 1975 and 2012 in which O-BD were contrasted with a comparison group (e.g., offspring of parents who had other psychiatric disorders or were healthy) on DRT outcomes and (ii) results reported for categorical or dimensional assessments of DRT (e.g., schizophrenia, psychotic symptoms, cluster A personality traits, or thought problems), yielding a total of 23 studies. Results Three key findings emerged: (i) categorical approaches of DRT in O-BD produced low incidence base rates and almost no evidence of significant differences in DRT between O-BD and comparison groups, whereas (ii) many studies using dimensional assessments of DRT yielded significant group differences in DRT. Furthermore, (iii) preliminary evidence from dimensional measures suggested that the developmental progression of DRT in O-BD might represent a prodrome of severe psychological impairment. Conclusions Preliminary but promising evidence suggests that DRT is a probable marker of risk for future impairment in O-BD. Methodological strengths and weaknesses, the psychometric properties of primary DRT constructs, and future directions for developmental and longitudinal research with O-BD are discussed.

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The prevalence of psychopathology in offspring of bipolar women from a Brazilian tertiary center

Abstract: Resultados: Os filhos de mães bipolares tiveram duas vezes mais chance de ter um ou mais diagnósticos de Eixo I [Razão de Prevalência = 2,11 (95% IC: 1,42) e p = 0,003] e 2,8 vezes maior risco de ter transtornos de ansiedade [Razão de prevalência = 2,83 (95% IC: 1,78)

Cited by 26 publications

References 34 publications

Longitudinal Trajectories of ADHD Symptomatology in Offspring of Parents With Bipolar Disorder and Community Controls

Longitudinal Trajectories of ADHD Symptomatology in Offspring of Parents With Bipolar Disorder and Community Controls

Mood disorders in childhood and adolescence

Disturbances in reality testing as markers of risk in offspring of parents with bipolar disorder: a systematic review from a developmental psychopathology perspective

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