The prevalence of psychiatric symptoms before the diagnosis of Parkinson’s disease in a nationwide cohort: A comparison to patients with cerebral infarction

Szatmári, Szabolcs; Ajtay, András; Oberfrank, Ferenc; Dobi, Balázs; Bereczki, Dániel

doi:10.1371/journal.pone.0236728

Cited by 11 publications

(4 citation statements)

References 38 publications

(44 reference statements)

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“…Once pontine structures (including the magnocellularis and subcoeruleus nuclei) are sufficiently dysfunctional, isolated REM sleep behavior disorder (iRBD) appears [64]. Involvement of other brainstem nuclei may give rise to prodromal neuropsychiatric symptoms including anxiety and mood disorders [65,66]. Supporting this, a recent study reported that depression and anxiety were more prevalent in iRBD patients compared with a group of unselected de novo PD patients [67].…”

Section: Utility Of the Soc Modelmentioning

confidence: 99%

The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson’s Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline

Borghammer

2021

JPD

131

111

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A new model of Parkinson’s disease (PD) pathogenesis is proposed, the α-Synuclein Origin site and Connectome (SOC) model, incorporating two aspects of α-synuclein pathobiology that impact the disease course for each patient: the anatomical location of the initial α-synuclein inclusion, and α-synuclein propagation dependent on the ipsilateral connections that dominate connectivity of the human brain. In some patients, initial α-synuclein pathology occurs within the CNS, leading to a brain-first subtype of PD. In others, pathology begins in the peripheral autonomic nervous system, leading to a body-first subtype. In brain-first cases, it is proposed that the first pathology appears unilaterally, often in the amygdala. If α-synuclein propagation depends on connection strength, a unilateral focus of pathology will disseminate more to the ipsilateral hemisphere. Thus, α-synuclein spreads mainly to ipsilateral structures including the substantia nigra. The asymmetric distribution of pathology leads to asymmetric dopaminergic degeneration and motor asymmetry. In body-first cases, the α-synuclein pathology ascends via the vagus to both the left and right dorsal motor nuclei of the vagus owing to the overlapping parasympathetic innervation of the gut. Consequently, the initial α-synuclein pathology inside the CNS is more symmetric, which promotes more symmetric propagation in the brainstem, leading to more symmetric dopaminergic degeneration and less motor asymmetry. At diagnosis, body-first patients already have a larger, more symmetric burden of α-synuclein pathology, which in turn promotes faster disease progression and accelerated cognitive decline. The SOC model is supported by a considerable body of existing evidence and may have improved explanatory power.

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Section: Utility Of the Soc Modelmentioning

confidence: 99%

The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson’s Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline

Borghammer

2021

JPD

131

111

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“…The imperative role of mental health professionals has been highlighted in terms of addressing the negative health beliefs and to reduce the overall stigma associated with mental disorders. 12,[20][21] .…”

Section: Discussionmentioning

confidence: 99%

Frequency of psychiatric illnesses and opinion/vantage of patients attending neurology out-patient department

et al. 2023

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Objective: To determine the Frequency of psychiatric illnesses in patients with neurological conditions, and to take their opinion about psychiatric disorders. Method: The cross-sectional study was conducted from June 1 to August 30, 2021, at the Neurology Outpatient Department of Allied Hospital, Faisalabad, Pakistan, and comprised patients of either gender aged 12-70 years from among those visiting the outpatient clinic. Data was collected through interviews and the 41-item Depression Anxiety Stress Scale. Data was analysed using SPSS 21. Results: Of the 201 patients, 160(79.6%) were females and 41(20.4%) were males. The overall mean age was 34.5+/-9.38 years. Primary neurological problem was headache 119(59.2%). Overall, 155(77.2%) patients met the criteria of psychiatric disorders; 55(27.4%) anxiety, 37(19.4%) had depressive disorder, 42(20.8%) mixed anxiety depressive disorder, and 19(9.5%) had other psychiatric illnesses. Also, 101(50.2%) patients lacked awareness about psychiatry illnesses, 35(17.4%) had fear of stigma, and 28(13.9%) had misconceptions. Conclusion: The Frequency of psychiatric disorders among those visiting the neurology outpatient department was high, and was associated with negative views about such illnesses. Key Words: Comorbidity, Neurology outpatient, Psychiatric illness, Opinion.

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“…In some cases, such symptoms can be reactive to the diagnosis of the CNS disorder itself [ 10 , 11 , 12 ], while in other cases they are reported as possible consequences of pharmacological treatments [ 13 , 14 ]. In addition, the same pathophysiological pathways underlying neurological manifestations can contribute to the development of psychopathological features in CNS disorders, strongly suggesting a neurobiological link between neurological and psychiatric symptoms [ 9 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Insights into the Pathophysiology of Psychiatric Symptoms in Central Nervous System Disorders: Implications for Early and Differential Diagnosis

Menculini

Chipi

Paoletti

et al. 2021

IJMS

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Different psychopathological manifestations, such as affective, psychotic, obsessive-compulsive symptoms, and impulse control disturbances, may occur in most central nervous system (CNS) disorders including neurodegenerative and neuroinflammatory diseases. Psychiatric symptoms often represent the clinical onset of such disorders, thus potentially leading to misdiagnosis, delay in treatment, and a worse outcome. In this review, psychiatric symptoms observed along the course of several neurological diseases, namely Alzheimer’s disease, fronto-temporal dementia, Parkinson’s disease, Huntington’s disease, and multiple sclerosis, are discussed, as well as the involved brain circuits and molecular/synaptic alterations. Special attention has been paid to the emerging role of fluid biomarkers in early detection of these neurodegenerative diseases. The frequent occurrence of psychiatric symptoms in neurological diseases, even as the first clinical manifestations, should prompt neurologists and psychiatrists to share a common clinico-biological background and a coordinated diagnostic approach.

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The prevalence of psychiatric symptoms before the diagnosis of Parkinson’s disease in a nationwide cohort: A comparison to patients with cerebral infarction

Cited by 11 publications

References 38 publications

The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson’s Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline

The α-Synuclein Origin and Connectome Model (SOC Model) of Parkinson’s Disease: Explaining Motor Asymmetry, Non-Motor Phenotypes, and Cognitive Decline

Frequency of psychiatric illnesses and opinion/vantage of patients attending neurology out-patient department

Insights into the Pathophysiology of Psychiatric Symptoms in Central Nervous System Disorders: Implications for Early and Differential Diagnosis

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