The prevalence of positive reactions in the atopy patch test with aeroallergens and food allergens in subjects with atopic eczema: a European multicenter study

Darsow, Ulf; Laifaoui, J.; Kerschenlohr, Karin; Wollenberg, Andreas; Przybilla, Bernhard; Wüthrich, B; Borelli, Siegfried; Giusti, Francesca; Seidenari, Stefania; Drzimalla, K.; Simon, Dagmar; Disch, Rainer; Devillers, A. C. A.; Oranje, Arnold P.; Raeve, Linda De; Hachem, Jean-Pierre; Dangoisse, Chantal; Blondeel, Arlette; Song, Micheline; Breuer, Kristine; Wulf, A.; Werfel, Thomas; Roul, S.; Taı̈eb, Alain; Bolhaar, Suzanne; Bruijnzeel-Koomen, Carla A.F.M.; Brönnimann, M.; Braathen, Lasse R.; Didierlaurent, A.; André, C.; Ring, Johannes

doi:10.1111/j.1398-9995.2004.00556.x

Cited by 235 publications

(219 citation statements)

References 35 publications

Supporting

Mentioning

195

Contrasting

Unclassified

Order By: Relevance

“…HDM was assumed to act not only as an allergen but also as a nonspecific irritant in AD skin lesions via a proteolytic activity of the HDM allergens. [25][26][27] In conclusion, this pilot study revealed that 24% of a group of allergic children from Cairo were sensitized to one or more of five strains of HDM, D. pteronyssinus and D. farinae being the most common. Testing children with several mite species would give information on the varied geographic distribution and might help efforts to develop more targeted specific immunotherapy.…”

Section: Discussionmentioning

confidence: 99%

Sensitivity to Five Types of House Dust Mite in a Group of Allergic Egyptian Children

Hossny

El-Sayed

Abdul-Rahman

2014

Pediatric Allergy, Immunology, and Pulmonology

View full text Add to dashboard Cite

Background: The published data on house dust mite (HDM) sensitization from Egypt are scanty. We sought to investigate the sensitization to five different types of HDM among a group of allergic children in a trial to outline the most frequent sensitizing strains in the Cairo Province. Methods: We consecutively enrolled 100 asthmatic patients, aged 1-7 years, of whom 22 had concomitant skin allergy. Skin prick testing was performed using allergen extracts of Dermatophagoides pteronyssinus, Dermatophagoides farinae, Lepidoglyphus destructor, Tyrophagus putrescentiae, and Acarus siro. Results: Twenty-four patients (24%) were sensitized to one or more strains of HDM. Sensitization to one strain was revealed in 12% of the studied sample, while sensitization to two or three strains was detected in 8% and 4% respectively. Twelve percent of the enrolled children were sensitive to D. pteronyssinus, 11% to D. farinae, 7% to L. destructor, 6% to T. putrescentiae, and 4% to A. siro. Eight out of the 12 (66%) children sensitive to one strain had mild intermittent asthma, while five out of eight (62.5%) sensitive to two strains had moderate persistent asthma. All children sensitized to three strains of HDM had persistent rather than intermittent asthma. HDM sensitization did not correlate significantly to the history of sun exposure, bed mattresses and pillows, living in farms, or exposure to stored grains. The co-existence of atopic dermatitis tended to have a higher rate of HDM sensitization. Conclusion: D. pteronyssinus and D. farinae represent the most common sensitizing strains in the studied sample. Wider-scale population-based studies are needed to assess the prevalence of HDM allergy and its clinical correlates in our country.

show abstract

Section: Discussionmentioning

confidence: 99%

Sensitivity to Five Types of House Dust Mite in a Group of Allergic Egyptian Children

Hossny

El-Sayed

Abdul-Rahman

2014

Pediatric Allergy, Immunology, and Pulmonology

View full text Add to dashboard Cite

show abstract

“…Indeed, in patients with food-triggered AD exacerbations, relevant food allergen-specific T cells have been detected in the peripheral blood as well as the skin (45,46). Moreover, positive atopy patch test (APT) reactions to inhalant and food allergens can be detected in the absence of corresponding IgE responses (47). Although widely used, the APT has limited value in the diagnosis of food allergy in EoE (16) perhaps owing to the fact that here the skin and not the esophagus is tested.…”

Section: Food-specific T-cell Responses In the Skinmentioning

confidence: 99%

Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity

Simon

Cianferoni

Spergel

et al. 2016

Allergy

Self Cite

199

130

View full text Add to dashboard Cite

Eosinophilic esophagitis (EoE) is a chronic disease characterized clinically by symptoms of esophageal dysfunction and histologically by eosinophil-predominant inflammation. EoE is frequently associated with concomitant atopic diseases and immunoglobulin E (IgE) sensitization to food allergens in children as well as to aeroallergens and cross-reactive plant allergen components in adults. Patients with EoE respond well to elemental and empirical food elimination diets. Recent research has, however, indicated that the pathogenesis of EoE is distinct from IgE-mediated food allergy. In this review, we discuss the individual roles of epithelial barrier defects, dysregulated innate and adaptive immune responses, and of microbiota in the pathogenesis of EoE. Although food has been recognized as a trigger factor of EoE, the mechanism by which it initiates or facilitates eosinophilic inflammation appears to be largely independent of IgE and needs to be further investigated. Understanding the pathogenic role of food in EoE is a prerequisite for the development of specific diagnostic tools and targeted therapeutic procedures.Abbreviations ACD, allergic contact dermatitis; AD, atopic dermatitis; APT, atopy patch test; DHR, drug hypersensitivity reactions; EoE, eosinophilic esophagitis; FPIES, food protein-induced enterocolitis; GERD, gastroesophageal reflux disease; GI, gastrointestinal; IBD, inflammatory bowel disease; Ig, immunoglobulin; OAS, oral allergy syndrome; PPI-REE, proton pump inhibitor-responsive esophageal eosinophilia; SFED, six-food elimination diet; SPT, skin prick test; TCR, T-cell receptor; TNF, tumor necrosis factor.Allergy 71 (2016) 611-620

show abstract

“…In a European multicenter study, which included 314 patients with AEDS, the frequency of clear-cut positive APT reactions ranged from 39% with dust mites to 9% with celery. A notable observation from the study was that positive APT in face of all SPT and sIgE testing negative was found in 7% of the patients, whereas a positive APT without SPT or sIgE for the respective allergen was seen in 17% of the patients (42). This lead the authors to conclude that, as no gold standard for aeroallergen provocation in AEDS exists, the relevance of aeroallergens for AEDS may be evaluated by APT in addition to SPT and sIgE.…”

Section: The Allergy Tests In Diagnosis Of Aedsmentioning

confidence: 85%

Atopic Dermatitis: From Pathophysiology to Diagnostic Approach

Fuiano¹,

Incorvaia²

2012

Atopic Dermatitis - Disease Etiology and Clinical Management

View full text Add to dashboard Cite

The prevalence of positive reactions in the atopy patch test with aeroallergens and food allergens in subjects with atopic eczema: a European multicenter study

Cited by 235 publications

References 35 publications

Sensitivity to Five Types of House Dust Mite in a Group of Allergic Egyptian Children

Sensitivity to Five Types of House Dust Mite in a Group of Allergic Egyptian Children

Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity

Atopic Dermatitis: From Pathophysiology to Diagnostic Approach

Contact Info

Product

Resources

About