The prevalence of polycystic ovary syndrome in adolescents: A systematic review and meta-analysis

Naz, Marzieh Saei Ghare; Tehrani, Fahimeh Ramezani; Majd, Hamid Alavi; Ahmadi, Fazlollah; Ozgoli, Giti; Fakari, Farzaneh Rashidi; Ghasemi, Vida

doi:10.18502/ijrm.v17i8.4818

Cited by 51 publications

(29 citation statements)

References 41 publications

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“…Therefore, our study aimed to check whether the levels of OS and inflammation markers in adolescent PCOS patients correlate with the consumption of proteins, carbohydrates and fiber, fats, and cholesterol. We investigated the above correlations separately in patients with normal weight and excess body weight, as the metabolic profile differs in overweight and obese PCOS patients compared to slim ones [ 6 , 7 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…The metabolic and hormonal profile is more severe in PCOS girls with excess body weight and overweight than normal-weighted. Obesity is observed in 40–70% of young women with PCOS [ 6 , 7 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. The prevalence of PCOS in adolescent girls based on a meta-analysis covering 149,477 patients from different countries (India, Iran, Thailand, Australia, and USA) is 8.67%.…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of PCOS in adolescent girls based on a meta-analysis covering 149,477 patients from different countries (India, Iran, Thailand, Australia, and USA) is 8.67%. Depending on the diagnostic criteria, the frequency is 11.04% (based on the Rotterdam criteria), 3.39% (based on the National Institutes of Health criteria), and 8.03% (based on Androgen Excess and Polycystic Ovary Syndrome Society criteria) [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Relation between Inflammation, Oxidative Stress, and Macronutrient Intakes in Normal and Excessive Body Weight Adolescent Girls with Clinical Features of Polycystic Ovary Syndrome

Mizgier¹,

Jarząbek-Bielecka

Wendland

et al. 2021

Nutrients

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The impact of diet on inflammation and oxidative stress (OS) in girls with polycystic ovary syndrome (PCOS) is unknown. Therefore, our study aimed to investigate, in PCOS girls, whether certain macronutrient intakes can be associated with these disturbances. For this purpose, 59 PCOS participants (aged 14–18 years) were recruited to this study and divided into two subgroups: overweight/obese—Ov/Ob group (n = 22) and normal weight—N group (n = 37). Nutrition was assessed using a 3-day food record. The studied markers were total antioxidant capacity (TAC), malondialdehyde (MDA), C-reactive protein (CRP), tumor necrosis factor α (TNF-α), and interleukins 1 and 6 (IL-1 and IL-6). We found plant protein intake inversely correlated with IL-6 (p = 0.007; r = −0.557), TNF-α (p = 0.006; r = −0.564), MDA (p = 0.01; r = −0.539) in the Ov/Ob group and with TAC (p = 0.021; r = −0.38) in the N group. Inverse correlations in the Ov/Ob group were observed between protein intake and IL-6 (p = 0.031; r = −0.461), TNF- α (p = 0.043; r = −0.435); carbohydrates and IL-6 (p = 0.037; r = −0.448), MDA (p = 0.045; r = −0.431); fiber and IL-6 (p = 0.025; r = −0.475). A positive relationship between cholesterol intake and CRP concentration (p = 0.038; r = 0.342) was also found in the N group. These findings revealed that inflammation and OS are increased in Ov/Ob girls with decreased plant protein intake and low carbohydrates in the diet. Moreover, inflammation may be increased by cholesterol intake in slim PCOS girls. On the other hand, decreased intake of fiber and total protein intake increased inflammation. ClinicalTrials.gov Identifier: NCT04738409.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relation between Inflammation, Oxidative Stress, and Macronutrient Intakes in Normal and Excessive Body Weight Adolescent Girls with Clinical Features of Polycystic Ovary Syndrome

Mizgier¹,

Jarząbek-Bielecka

Wendland

et al. 2021

Nutrients

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“…Polycystic ovary syndrome (PCOS) is the most common cause of hyperandrogenism in girls and women. According to the commonly used Rotterdam criteria, the incidence of PCOS in women ranges from 3% to 26%, and in adolescents it is about 8% [1][2][3]. Clinically hyperandrogenism is manifested by severe acne, scanty or infrequent menstruations, and male hirsutism.…”

Section: Introductionmentioning

confidence: 99%

Risk Factors of Overweight and Obesity Related to Diet and Disordered Eating Attitudes in Adolescent Girls with Clinical Features of Polycystic Ovary Syndrome

Mizgier¹,

Jarząbek-Bielecka

Opydo-Szymaczek

et al. 2020

JCM

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Background: We aimed to find the difference between girls with clinical features of Polycystic ovary syndrome (PCOS), divided into two groups: Overweight/obesity (Ov/Ob) and normal weight (N), related to diet, disordered eating attitudes (DEA), metabolic and hormonal differences, and to identify the risk factors of being overweight or obese. Methods: Seventy-eight adolescents with PCOS, aged 14–18 years, were divided into Ov/Ob and N groups. Patients underwent blood tests for determination of follicle-stimulating hormone (FSH), luteinizing hormone (LH), total testosterone, DHEA-S, estradiol, of sex hormone-binding globulin (SHBG), fasting glucose, insulin, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), and lipid profile. Nutrition was evaluated using a 3-day food record. To examine the level of DEA, the Eating Attitudes Test-26 (EAT-26) was used. We defined an EAT-26 score ≥20 as positive for DEA. Logistic regression was carried out to identify the independent predictors of being overweight and obese. Results: An increase of 10 g in plant protein intake decreased the probability of being overweight and of obesity (OR = 0.54; p = 0.036). EAT-26 score ≥20 was correlated with a 7-fold (OR = 6.88; p = 0.02) increased odds of being overweight or of obesity. Conclusion: Being overweight and obesity in adolescents with PCOS may be associated with DEA and the type and amount of protein intake.

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“…Therefore, to overcome this major diagnostic variation differences there is a need to go for ethnic specific guidelines for PCOS. 3 PCOS is a set of symptoms represented and described by irregular menstrual cycle, sterility, androgen excess and insulin resistance. 4 PCOS has long lasting hazards such as cardiovascular illnesses, Type-2 DM, dyslipidemia and endometrial carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Serum apelin levels in polycystic ovary syndrome and its relationship with adiposity profile in females.

Kanwal

Allahwasaya

Anjum

et al. 2021

TPMJ

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Objectives: The purpose of the current study was to compare the serum Apelin level in patients with and without polycystic ovarian syndrome to assess this as a diagnostic marker for PCOS. In a case-control study 60 polycystic ovarian syndrome patients diagnosed according to Rotterdam criteria and 20 healthy controls of reproductive age group were recruited. Study Design: Case Control study. Setting: Jinnah Postgraduate Medical Center in Collaboration with Aga Khan University, Karachi. Period: August 2017 and February 2019. Material & Methods: Blood samples were collected after 12 hours fasting and was used to test serum Apelin, insulin, cortisol and fasting blood glucose levels. Results: Seventy percent PCO subjects had irregular menstrual cycle and 68% suffered from hirsutism; while all PCO subjects had more than 10 antral follicle seen on ultrasound in either one or both ovaries in comparison of 15% controls (p<0.05). Higher Apelin and Testosterone levels in PCO group was reported when compared with controls (p<0.05) across all BMI categories. Apelin showed a positive correlation with number of ovarian cysts (r=0.429; p=0.000); irregular menstrual cyle (r=0.276;p=0.13); blood glucose level (r=0.270; p=0.015) and BMI (r=0.229; p=0.14). Apelin remained independently associated with the risk of PCOS (p=0.020) and elevated testosterone levels (p=0.030). Conclusion: Serum Apelin showed a strong association with irregular menstruation, hirsutism, ovarian cysts, testosterone and deranged blood glucose levels. Therefore, Apelin appears as a potential source for several risk factor in PCOS women of all BMI types.

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The prevalence of polycystic ovary syndrome in adolescents: A systematic review and meta-analysis

Cited by 51 publications

References 41 publications

Relation between Inflammation, Oxidative Stress, and Macronutrient Intakes in Normal and Excessive Body Weight Adolescent Girls with Clinical Features of Polycystic Ovary Syndrome

Relation between Inflammation, Oxidative Stress, and Macronutrient Intakes in Normal and Excessive Body Weight Adolescent Girls with Clinical Features of Polycystic Ovary Syndrome

Risk Factors of Overweight and Obesity Related to Diet and Disordered Eating Attitudes in Adolescent Girls with Clinical Features of Polycystic Ovary Syndrome

Serum apelin levels in polycystic ovary syndrome and its relationship with adiposity profile in females.

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