The Prevalence of Polycystic Ovarian Syndrome, Metabolic Abnormalities and Its Association With Obesity in Adolescents: A Cross-Sectional Study in an Urban Population in Iran

Abstract

The diagnosis of polycystic ovary syndrome (PCOS) and metabolic syndrome (MS) in adolescents is clinically challenging. It is on the rise as consistent with the increasing trends in obesity rates. This study aimed to investigate the prevalence of PCOS in adolescents by the National Institutes of Health (NIH) criteria and compare the prevalence of insulin resistance (IR) and metabolic syndrome (MS) between obese (OB) and non-obese (NOB) adolescents with PCOS. This was cross-sectional research with multi-stage cluster random sampling. Participants were 15-18-year-old girls from high schools in Semnan, Iran. The ones who had a history of menstrual dysfunction underwent clinical and hormonal tests. From among a total of 900 participants, 74 girls (8.2%) had a history of menstrual dysfunction. The prevalence of PCOS was 6.44% by NIH criteria. The prevalence of abnormal glucose metabolism, MS, and IR in girls with PCOS were 8(13.7%), 6(10.3%), 24(41.4%), respectively. The OB-PCOS group with a mean BMI of 28.21±1.26 kg/m2 had a significantly greater prevalence of MS, high BP, waist circumference ≥88 cm, and higher IR than NOB-PCOS cases with a mean BMI of 20.54±2.97 kg/m2. Abnormal glucose metabolism was prevalent in adolescents with PCOS and occurred with equal frequency in OB and NOB PCOS groups. Obesity could worsen IR, MS, and some of the components of Mets in PCOS adolescents.

Frequency of Insulin Resistance Among Infertile Women with Polycystic Ovary Syndrome at Zagazig University Hospitals

“…These findings agreed with the findings of this investigation. In the study done by Azargoon et al (17) the percentage of infertile women with PCOS who also had IR was 39.3 percent, and this result was also similar to the study of Jamil et al (18) in their research of 263 women with PCOS, 42.6% had IR. These results were lower than our study results.…”

Prevalence of Common Gynecological Conditions in the Middle East: Systematic Review and Meta-Analysis

“…Due to high heterogeneity ( I 2 = 94.0%) observed among the studies, results are presented from a random-effects model. Pooled prevalence of PCOS in the Levant region and Persian region was estimated at the lower range of the scale with 6.3% (95% CI: 4.4–8.6; range: 6.1–7.3%) ( 6 , 91 ) and 6.7% (95% CI: 4.6–9.1; range: 3.0–11.3%) ( 69 , 71 , 74 , 75 , 77 – 79 ), respectively, whereas prevalence estimates in the Gulf Arab states were 18.8% (95% CI: 9.5–30.3; range: 12.0–27.6%) ( 92 , 93 , 105 ). The population-based pooled prevalence according to the Rotterdam criteria was 11.9% (95% CI: 7.1–17.6; range: 3.4–19.9%) but only included studies from Iran and Turkey, from the Persian and Levant regions ( Figure 2B ).…”

“…Characteristics of the 47 studies included in the meta-analysis.Frontiers in Reproductive Health | www.frontiersin.org Summary of the quality assessment of the studies reporting the outcomes of interest included in the meta-analyses. 3%) (6, 91) and 6.7% (95% CI: 4.6-9.1; range: 3.0-11.3%)(69,71,74,75,(77)(78)(79), respectively, whereas prevalence estimates in the Gulf Arab states were 18.8% (95% CI: 9.5-30.3; range: 12.0-27.6%)(92,93,105). The population-based pooled prevalence according to the Rotterdam criteria was 11.9% (95% CI: 7.1-17.6; range: 3.4-19.9%) but only included studies from Iran and Turkey, from the Persian and Levant regions (Figure…”