The prevalence of Parkinson’s disease in a rural area of North-East England

Walker, Richard; Hand, Annette; Jones, Catherine R. G.; Wood, Brian; Gray, William K.

doi:10.1016/j.parkreldis.2010.07.002

Cited by 27 publications

(29 citation statements)

References 20 publications

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“…We acknowledge that we will not have identified all cases of PD within the catchment area. We have previously conducted two prevalence studies with prospective case ascertainment using multiple overlapping sources in the study areas 7 8…”

Section: Discussionmentioning

confidence: 99%

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Palliative care in people with idiopathic Parkinson's disease who die in hospital

Walker

Churm

Dewhurst

et al. 2013

BMJ Support Palliat Care

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For those dying in hospital, there are few previously documented end-of-life care discussions with patients or their relatives. The use of end-of-life pathways and access to specialist palliative care is variable. Following the Neuberger report, the Liverpool Care Pathway is to be replaced with individual end-of-life care plans. It is important to engage patients, and their relatives, in decision making regarding preferences at the end of life.

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Section: Discussionmentioning

confidence: 99%

“…Those who died between 1 January 2008 and 31 December 2011 (Northumberland area) and 1 January 2008 and 31 December 2010 (North Tyneside area) were included. Previous PD prevalence studies by our team have demonstrated that the PD service is responsible for well over 80% of people with PD in the Trust's catchment area 7 8…”

Section: Methodsmentioning

confidence: 97%

Palliative care in people with idiopathic Parkinson's disease who die in hospital

Walker

Churm

Dewhurst

et al. 2013

BMJ Support Palliat Care

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“…We recently reported that the crude prevalence of PD in North Northumberland was 178 cases per 100,000 (95% CI = 144-212), with an age-adjusted prevalence of 142 per 100,000 (95% CI = 118-165) [12]. Participants in this study were recruited from those people identified as having PD from the prevalence study and were interviewed and assessed at the same time as assessment for the prevalence study was carried out.…”

Section: Methodsmentioning

confidence: 99%

Self-Reported Dysphagia and Its Correlates Within a Prevalent Population of People with Parkinson’s Disease

2010

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Many people with Parkinson's disease (PD) experience dysphagia; however, the prevalence of dysphagia in people with PD is unknown. We studied a prevalent population of PD cases. All of those who consented to participate were assessed for anxiety, depression, cognitive function, and quality of life using standard rating scales. Anyone who answered "yes" to either one of the two questions: Do you have difficulty swallowing food/liquid or tablets? and Do you cough after eating/drinking? was considered to have dysphagia. Question 7 of the Unified Parkinson's Disease Rating Scale (UPDRS) was also used to identify dysphagia. Of 106 prevalent PD cases, 75 (38 males) patients consented to examination and assessment. The prevalence of dysphagia was 32.0% (n=24; 11 males). Using the response to UPDRS Question 7 as an indicator of the impact of swallowing problems on the patient, there were significant correlations with cognitive function, anxiety, depression, quality of life, and UPDRS-reported gait disturbance, postural instability and problems with falling. There was no correlation with disease duration, age, or gender. Almost one third of the participants reported dysphagia. There was a strong correlation between dysphagia and gross motor skills; patients reporting such problems should be screened for swallowing problems.

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“…The fact that pesticides have been widely implicated in PD has led to numerous epidemiological studies suggesting that those living in rural areas are more susceptible to developing PD (Berry et al, 2010;Brown et al, 2006). Other studies, however, have concluded that those living in rural areas are no more likely to develop PD than their city counterparts (Chen et al, 2009;Walker et al, 2010). The study of pesticides, in particular Paraquat and Rotenone, as causative agents of PD gained significant attention when it was discovered that they were toxicologically or structurally similar to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine).…”

Section: Identifying and Predicting Parkinson's Disease What Causes Pd?mentioning

confidence: 99%

Can Parkinson's disease pathology be propagated from one neuron to another?

Dunning

Reyes

Steiner

et al. 2012

Progress in Neurobiology

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Parkinson's disease is the second most prevalent neurodegenerative disease, yet despite this, very little is known about the underlying cellular mechanisms.Initially it was thought to be a disease primarily involving loss of dopaminergic neurons in the substantia nigra pars compacta. Recent studies, however, have focused on observations that aggregated -synuclein protein, the major component of Lewy bodies, is found throughout the nervous system. It is speculated that misfolded -synuclein transfers between cells in a prion-like manner, thereby mediating the spread of the neuropathology. In this review, we discuss the staging (according to Braak) of Parkinson pathology and the concept describing the disease progression from one region of the brain to the other. We highlight how -synuclein might be responsible for the spread of the disease. We compare the idea of a prion-like mechanism contributing to Parkinson's disease to emerging concepts that other proteins participate in similar processes in other neurodegenerative diseases. We then examine the future implications of a critical role in disease pathogenesis of -synuclein for the classification, diagnosis and treatment of Parkinson's disease in the future.

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The prevalence of Parkinson’s disease in a rural area of North-East England

Cited by 27 publications

References 20 publications

Palliative care in people with idiopathic Parkinson's disease who die in hospital

Palliative care in people with idiopathic Parkinson's disease who die in hospital

Self-Reported Dysphagia and Its Correlates Within a Prevalent Population of People with Parkinson’s Disease

Can Parkinson's disease pathology be propagated from one neuron to another?

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