The Prevalence of OSA Among an Adult Population With Down Syndrome Referred to a Medical Clinic

Cornacchia, Michelle; Sethness, Janis L.; Alapat, Philip; Lin, Yu-Hsiang; Peacock, Cynthia

doi:10.1352/1944-7558-124.1.4

Cited by 15 publications

(13 citation statements)

References 14 publications

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“…With 157 adult DS patients with proven OSA, ours is the largest study in adult DS population to date. Half of our patients had severe OSA, similar to the 69% reported by others (Cornacchia, Sethness, Alapat, Lin, & Peacock, 2019; Trois et al, 2009). Our study does not directly measure overall prevalence of OSA in DS adults, as sleep studies were not routinely performed in all DS patients, but only in those with a clinical suspicion and presumed CPAP feasibility (roughly 11% of the total cohort).…”

Section: Discussionsupporting

confidence: 91%

“…With this limitation in mind, adults with DS may have a prevalence of OSA much higher than the general population, probably related to the morphology of the upper airway, a shorter and thicker neck, and associated overweight, as observed in our study and in others (Dudoignon et al, 2017; Gimenez et al, 2018; Young, 2009). Indeed, a recent study reported severe OSA in up to a third of DS adults (Cornacchia et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

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Obstructive sleep apnea in adults with Down syndrome

Landete

Soriano

Aldave

et al. 2020

American J of Med Genetics Pt A

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Patients with Down syndrome (DS) often have a high occurrence of obstructive sleep apnea-hypopnea (OSA) syndrome. We studied a large cohort of adults with DS attended due to clinical suspicion of OSA. A standardized questionnaire and full medical assessment were conducted, including a sleep study. One hundred and fiftyseven DS individuals were studied, with a mean ± SD age of 36 ± 10 years, 40.7% women, BMI 29.4 ± 5.6 kg/m 2. The main clinical symptom was daytime sleepiness (64.9%). A sleep study was conducted in 114 patients. All 114 DS patients were diagnosed with OSA, with a predominance of obstructive and hypopnea events, (apneahypopnoea index, AHI, 35.0 ± 26.6), with an oxygen desaturation index of 32.9, and a Tc90% of 24.7%. Continuous positive airway pressure (CPAP) treatment was implemented in 75 (65.8%) of subjects. Tolerance was considered good in 75% of them, with a high compliance of 79.2% >4 hr/day (mean 7.1 hr/day), resulting in a symptomatic improvement in 58.7% of them. Obstructive sleep apnea is frequently confirmed in patients with DS when it clinically suspected.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Obstructive sleep apnea in adults with Down syndrome

Landete

Soriano

Aldave

et al. 2020

American J of Med Genetics Pt A

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“…Dr. Rebillat reported that 77.4% of 31 adults with DS had OSA, and 48.4% had severe OSA. Results were similar to previously reported systematic screening for OSA in 47 non-symptomatic individuals, of whom 72.3% had OSA including 31.9% with severe OSA in Europe [Giménez et al, 2018] and in the USA [Cornacchia et al, 2019]. These data confirm that subjective evaluation underestimates the presence of apneas in individuals with DS and that objective sleep measures and systematic screening are essential.…”

Section: Health Comorbidities In Older Adults With Ds -Assessment and Diagnosissupporting

confidence: 89%

Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society

Dierssen¹,

Hérault²,

Helguera³

et al. 2021

Mol Syndromol

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Research focused on Down syndrome has increased in the last several years to advance understanding of the consequences of trisomy 21 (T21) on molecular and cellular processes and, ultimately, on individuals with Down syndrome. The Trisomy 21 Research Society (T21RS) is the premier scientific organization for researchers and clinicians studying Down syndrome. The Third International Conference of T21RS, held June 6–9, 2019, in Barcelona, Spain, brought together 429 scientists, families, and industry representatives to share the latest discoveries on underlying cellular and molecular mechanisms of T21, define cognitive and behavioral challenges and better understand comorbidities associated with Down syndrome, including Alzheimer’s disease and leukemia. Presentation of cutting-edge results in neuroscience, neurology, model systems, psychology, cancer, biomarkers and molecular and pharmacological therapeutic approaches demonstrate the compelling interest and continuing advancement in all aspects of understanding and ameliorating conditions associated with T21.

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“…Gender does not seem to influence OSA prevalence in adults with DS [ 2 , 14 , 19 , 21 ], whereas in the general population, there is a higher prevalence among males [ 35 ]. There is conflicting evidence on the impact of obesity on OSA prevalence in the DS population, with some studies showing a positive correlation between body mass index and OSA in children [ 45 ] and adults [ 2 , 17 , 20 , 21 , 22 ] but not others [ 14 , 16 , 19 , 37 ]. In the general population, obesity predisposes people to OSA due to excessive fat deposition in the neck and waist, but this relationship is less clear in children and adults with DS [ 21 ].…”

Section: Sleep Disordersmentioning

confidence: 99%

Sleep Disorders in Adults with Down Syndrome

Giménez

Altuna

Blessing

et al. 2021

JCM

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Sleep disorders, despite being very frequent in adults with Down syndrome (DS), are often overlooked due to a lack of awareness by families and physicians and the absence of specific clinical sleep guidelines. Untreated sleep disorders have a negative impact on physical and mental health, behavior, and cognitive performance. Growing evidence suggests that sleep disruption may also accelerate the progression to symptomatic Alzheimer’s disease (AD) in this population. It is therefore imperative to have a better understanding of the sleep disorders associated with DS in order to treat them, and in doing so, improve cognition and quality of life, and prevent related comorbidities. This paper reviews the current knowledge of the main sleep disorders in adults with DS, including evaluation and management. It highlights the existing gaps in knowledge and discusses future directions to achieve earlier diagnosis and better treatment of sleep disorders most frequently found in this population.

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The Prevalence of OSA Among an Adult Population With Down Syndrome Referred to a Medical Clinic

Cited by 15 publications

References 14 publications

Obstructive sleep apnea in adults with Down syndrome

Obstructive sleep apnea in adults with Down syndrome

Building the Future Therapies for Down Syndrome: The Third International Conference of the T21 Research Society

Sleep Disorders in Adults with Down Syndrome

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