The prevalence of neuropsychiatric syndromes in systemic lupus erythematosus

Ainiala, Hanna; Loukkola, Jukka; Peltola, Jukka; Korpela, Markku; Hietaharju, Aki

doi:10.1212/wnl.57.3.496

Cited by 420 publications

(334 citation statements)

References 28 publications

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“…In general, prevalence of psychiatric manifestations is high in the SLE patients. 6,24,25 Of those, depression is one of the most common mental illnesses. 26 Similar to present findings, the recent studies suggest that the point prevalence of depressive disorder in SLE is up to 39%, 27 while the lifetime prevalence is up to 69%, 28,29 which is far more prevalent than that of the general population in which the point and lifetime prevalence is 6.1% and 10.3%, respectively.…”

Section: Discussionmentioning

confidence: 99%

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772 – Prevalence and predictors of depression in patients with systemic lupus erythematosus: a cross-sectional study

Maneeton

Louthrenoo

2013

European Psychiatry

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Objective: The purpose of this study was to estimate the prevalence and examine the predictors of depression in patients with systemic lupus erythematosus (SLE). Methods: This cross-sectional study was conducted in the rheumatology clinic of a university hospital. All SLE patients that met the revised American College of Rheumatology (ACR) classification were included in the study. Sociodemographic data and medications were recorded. Disease activity for SLE was assessed with the Mexican-SLE Disease Activity Index (Mex-SLEDAI). All subjects were screened for anxiety and depression by using the Hamilton Anxiety Rating Scale (HAM-A) and the 17-item version of the Hamilton Depression Rating Scale (HAM-D17). Multiple linear regression analyses were used to determine predictors of depressive disorder. Results: A total of 62 SLE (61 females and 1 male) patients participated in the study. Based on HAM-D17 and HAM-A, rates of depression and anxiety in SLE patients were 45.2% and 37.1%, respectively. The multiple linear regression analysis revealed that HAM-A score and younger age were significant predictors of depression in SLE patients. Conclusion:The findings suggest that depression and anxiety are common in SLE patients. In addition, higher levels of anxiety and a younger age may increase the risk of depression. Because of the small sample size, further studies should be conducted to confirm these results.

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Section: Discussionmentioning

confidence: 99%

“…4,5 Therefore, it can cause several neuropsychiatric syndromes, including depression. 6,7 Recent evidence suggests that the prevalence of depression in SLE patients is between 11.5% and 47%. [8][9][10][11][12][13] In addition, a recent study suggests that severity of depression increases with more severe disease activity of SLE.…”

Section: Introductionmentioning

confidence: 99%

772 – Prevalence and predictors of depression in patients with systemic lupus erythematosus: a cross-sectional study

Maneeton

Louthrenoo

2013

European Psychiatry

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“…Reflecting the historically variable diagnostic criteria, estimates of neuropsychiatric SLE incidence in lupus patients range widely, from ~15% to 80%. 41–43 Notably, psychiatric symptoms do not appear to be correlated with flare-ups in systemic disease, 44 further confounding diagnosis and emphasizing the need to rule out other potential etiologies (e.g., infection, steroid-induced psychiatric symptoms, and primary psychiatric disturbances).…”

Section: Encephalopathy In Lupus and Other Systemic Syndromesmentioning

confidence: 99%

The Emerging Link Between Autoimmune Disorders and Neuropsychiatric Disease

Kayser¹,

Dalmau²

2011

Journal of Neuropsychiatry

109

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“…However in children, NPSLE is probably more common and more severe, with some studies reporting a prevalence rate of up to 95%. [1][2][3][4][5] However, many studies have reported widely varying figures on the prevalence of NPSLE in both adults and children. The heterogeneity of this clinical subset of SLE complicates elucidation of its pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis of neurocognitive and neuropsychiatric manifestations in childhood-onset lupus: an overview

2014

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This review explores current understanding of neuropsychiatric systemic lupus erythematosus (NPSLE) of childhood onset, in particular neurocognitive impairment. As yet, fewer studies have focused on childhood onset NPSLE compared to adult onset NPSLE and diagnosis still involves the 1999 American College of Rheumatology case definitions of neuropsychiatric syndromes, which were developed for adults. Although a validated core set of neuropsychometric tests exist for childhood onset NPSLE, these still have limitations and possible biomarkers and newer neuroimaging modalities remain mostly experimental. Important differences exist between childhood and adult onset SLE and specifically with NPSLE, outlined in this review. Normal adolescent brain development also involves significant differences from adults, particularly in executive function and social cognition. These issues may impact on the pathogenesis of NPSLE during this vulnerable period and also influence their management options.

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The prevalence of neuropsychiatric syndromes in systemic lupus erythematosus

Abstract: According to the ACR nomenclature, there is a high prevalence of NP manifestations in a population-based sample of patients with SLE. Most NP syndromes were classified as minor; if they were excluded, the 46% prevalence of NPSLE would be slightly less than estimated in previous studies.

Cited by 420 publications

References 28 publications

772 – Prevalence and predictors of depression in patients with systemic lupus erythematosus: a cross-sectional study

772 – Prevalence and predictors of depression in patients with systemic lupus erythematosus: a cross-sectional study

The Emerging Link Between Autoimmune Disorders and Neuropsychiatric Disease

Pathogenesis of neurocognitive and neuropsychiatric manifestations in childhood-onset lupus: an overview

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