The prevalence of Myocardial Infarction among Multiple Sclerosis Patients: a Systematic Review and Meta-analysis

Tavallaei, Mohammad Javad; Tavallaei, Amir Hossein; Ebrahimi, Narges; Ghoshouni, Hamed; Afshari-Safavi, Alireza; Badihian, Shervin; Shaygannejad, Vahid; Mirmosayyeb, Omid

doi:10.1016/j.msard.2021.103292

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…A meta-analysis, namely, 12 studies of 471,874 individuals indicated that compared with the general population, the risk of CVDs in patients with MS increased 29% (OR, 1.29; 95% CI, 1.80–2.51) ( 30 ). Another recent meta-analysis comprising 19 studies (44 to 66,616 participants) reported that the pooled OR estimate for MI was 1.41 in MS patients compared to the healthy controls ( 31 ). Besides, a meta-analysis of 9 observational studies suggested that MS was associated with an increased risk of MI and HF, but not ischemic heart disease or bradycardia ( 32 ).…”

Section: Discussionmentioning

confidence: 99%

Multiple Sclerosis and the Risk of Cardiovascular Diseases: A Mendelian Randomization Study

Yang

Teng

et al. 2022

Front. Immunol.

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BackgroundObservational studies suggested that multiple sclerosis (MS) is associated with cardiovascular diseases (CVDs). However, the causal association has not been fully elucidated. Thus, we aim to assess the causality of the associations of MS with risk of CVDs.MethodsA two-sample Mendelian randomization (MR) study was performed to explore the causality. Genetic instruments were identified for MS from a genome-wide association study (GWAS) involving 115,803 individuals. Summary-level data for CVDs were obtained from different GWAS meta-analysis studies. MR analysis was conducted mainly using the inverse-variance weighted (IVW) method. Sensitivity analyses were further performed to ensure the robustness of the results.ResultsThis MR study found suggestive evidence that genetic liability to MS was associated with an increased risk of coronary artery disease (CAD) [odds ratio (OR), 1.02; 95% confidence interval (CI), 1.00–1.04; p = 0.03], myocardial infarction (MI) (OR, 1.03; 95% CI, 1.00–1.06; p = 0.01), heart failure (HF) (OR, 1.02; 95% CI, 1.00–1.04; p = 0.02), all-cause stroke (AS) (OR, 1.02; 95% CI, 1.00–1.05; p = 0.02), and any ischemic stroke (AIS) (OR, 1.02; 95% CI, 1.00–1.05; p = 0.04). The null-association was observed between MS and the other CVDs. Further analyses found little evidence of pleiotropy.ConclusionsWe provided suggestive genetic evidence for the causal associations of MS with increased risk of CAD, MI, HF, AS, and AIS, which highlighted the significance of active monitoring and prevention of cardiovascular risk to combat cardiovascular comorbidities in MS patients.

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Section: Discussionmentioning

confidence: 99%

Multiple Sclerosis and the Risk of Cardiovascular Diseases: A Mendelian Randomization Study

Yang

Teng

et al. 2022

Front. Immunol.

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“…In addition, a meta-analysis has revealed a positive association between IBD and the incidence of cardiovascular disease (CVD) [3, 4]. Similarly, previous studies showed that autoimmune disease [5], including multiple sclerosis [6], rheumatoid arthritis (RA) [7], and systemic lupus erythematous (SLE) [8], was a risk factor for CVD.…”

Section: Introductionmentioning

confidence: 99%

Association between Mucosal Healing and Lipid Profiles in Patients with Ulcerative Colitis: A Cross-Sectional Study

et al. 2022

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Introduction: Recent meta-analysis showed that ulcerative colitis (UC) is a risk factor for cardiovascular disease (CVD). Dyslipidemia is a well-established risk factor for CVD. However, evidence regarding inflammatory bowel disease (IBD), including UC and lipid profiles, is limited. Additionally, no study has assessed the association between endoscopic activity and lipid profiles in patients with IBD. Therefore, we aimed to clarify the association between mucosal healing (MH) and lipid profiles in patients with UC. Methods: A total of 221 Japanese patients with UC were enrolled in this analysis. Total cholesterol (T-chol), triglyceride (TG), and high-density lipoprotein cholesterol (HDL-C) were divided into tertiles (high, moderate, and low) based on the distributions, respectively. Self-administered questionnaire was used to obtain information regarding medication for dyslipidemia. Complete MH and MH are based on Mayo endoscopic subscore 0 and 0–1, respectively. Results: The percentage of complete MH was 30.8%. In patients without medication for dyslipidemia, high HDL-C (>66 mg/dL) was significantly positively associated with complete MH (adjusted odds ratio [OR] 2.58, 95% CI: 1.04–6.64, p for trend = 0.037). In patients with nonproctitis, a positive association between HDL-C and complete MH was found (adjusted OR 3.54, 95% CI: 1.22–11.01, p for trend = 0.020). T-chol and TG were not associated with MH, regardless of medication for dyslipidemia. Conclusions: Complete MH was significantly positively associated with HDL-C in UC patients without medication for lipid. The disease extent might affect the association between complete MH and HDL-C.

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Acute myocardial infarction in patients with multiple sclerosis; An insight from 1785 cases in the United States

Ramphul

Kumar

Verma

et al. 2022

Multiple Sclerosis and Related Disorders

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The prevalence of Myocardial Infarction among Multiple Sclerosis Patients: a Systematic Review and Meta-analysis

Cited by 3 publications

References 24 publications

Multiple Sclerosis and the Risk of Cardiovascular Diseases: A Mendelian Randomization Study

Multiple Sclerosis and the Risk of Cardiovascular Diseases: A Mendelian Randomization Study

Association between Mucosal Healing and Lipid Profiles in Patients with Ulcerative Colitis: A Cross-Sectional Study

Acute myocardial infarction in patients with multiple sclerosis; An insight from 1785 cases in the United States

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