The Prevalence of Multiple Sleep-Onset REM Periods in a Population-Based Sample

Singh, Meeta; Drake, Christopher L.; Roth, Thomas

doi:10.1093/sleep/29.7.890

Cited by 113 publications

(67 citation statements)

References 25 publications

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“…Our data show a lower prevalence of C− over C+, in line with most clinical studies 8 22 23. However, recent data on adult populations demonstrated that a high prevalence of EDS combined with MSLT abnormalities is compatible with a diagnosis of C− 24 25…”

Section: Discussionsupporting

confidence: 91%

Psychological health in central hypersomnias: the French Harmony study

Dauvilliers

Paquereau²,

Bastuji³

et al. 2009

Journal of Neurology, Neurosurgery & Psychiatry

155

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Section: Discussionsupporting

confidence: 91%

Psychological health in central hypersomnias: the French Harmony study

Dauvilliers

Paquereau²,

Bastuji³

et al. 2009

Journal of Neurology, Neurosurgery & Psychiatry

155

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“…Healthy subjects with multiple SOREMs were sleepier [35,36,37] than subjects with 1 or no SOREM. None of the 11 patients with MSL ≤5 min presented with SOREM.…”

Section: Discussionmentioning

confidence: 99%

Excessive Daytime Sleepiness in Parkinson’s Disease: Characteristics and Determinants

et al. 2010

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Background/Aims: Excessive daytime sleepiness (EDS) is frequent in patients with Parkinson’s disease (PD). Occasionally, EDS in PD exhibits narcolepsy-like features. We aimed to assess characteristics and determinants of EDS in consecutive patients with PD. Methods: Thirty consecutive patients with PD underwent a detailed clinical examination. EDS was assessed using the Epworth Sleepiness Scale (ESS) and Multiple Sleep Latency Test (MSLT). Sleep was assessed using video-polysomnography. Cerebrospinal fluid (CSF) hypocretin-1 levels were obtained in 3 patients. Results: ESS was >10 in 17 patients (57%). Mean sleep latency (MSL) on MSLT was <5 min in 11 patients (37%). There was a significant negative correlation between ESS and MSL. None of the 11 patients with MSL <5 min showed a sleep onset REM (SOREM) episode. Patients with EDS had higher dopamine agonists/levodopa equivalent doses, higher apnea/hypopnea index and exhibited wearing-off symptoms more often. Hypocretin-1 was normal in 3 patients tested. Conclusion: EDS, which can sometimes be severe, is common in PD patients even in the absence of SOREM and detectable CSF-hypocretin deficiency. In PD, EDS is a multifaceted phenomenon, the determinants of which include severity of PD, wearing-off symptoms, dosage of antiparkinsonian drugs and sleep-disordered breathing.

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“…Age and sex have already been shown to influence NPSG REML in patients with narcolepsy and controls 5,33–35 ; we therefore matched patients and controls for these variables before comparisons. As a consequence, the total number of patients and controls was reduced to 516 pairs (some patients did not have a matching control).…”

Section: Methodsmentioning

confidence: 99%