The Prevalence of Malocclusion and Periodontal Diseases and Their Correlation in Samegrelo Region, Georgia

Kvaratskhelia, S; Gogiberidze, Mamuka; Orjonikidze, Mariam; Puturidze, S; Jorbenadze, T

doi:10.18502/ijph.v51i1.8314

Cited by 1 publication

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“…Inflammation can interfere with normal bone metabolism, leading to periodontal membrane damage, alveolar bone loss, and even tooth loss (Karthikeyan Murthykumar & Kaarthikeyan, 2020), which frequently occurs during orthodontic treatment in periodontally compromised patients and sometimes impact periodontal treatment (Kvaratskhelia et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

“…Periodontitis is a chronic inflammation of periodontal supporting tissues (gums, bone, and periodontal membranes) caused by plaque, and local factors such as calculus and traumatic occlusions contribute to rapid progression of periodontitis (Manresa et al, 2018). Inflammation can interfere with normal bone metabolism, leading to periodontal membrane damage, alveolar bone loss, and even tooth loss (Karthikeyan Murthykumar & Kaarthikeyan, 2020), which frequently occurs during orthodontic treatment in periodontally compromised patients and sometimes impact periodontal treatment (Kvaratskhelia et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

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ZEB1 interferes with human periodontal ligament stem cell proliferation and differentiation

Qian

Zhang

2023

Oral Diseases

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BackgroundPeriodontitis can eventually contribute to tooth loss. Zinc finger E‐box binding homeobox 1 (ZEB1) is identified as overexpressed in the gingival tissue of mice with periodontitis. This study is designed to decipher the mechanism of ZEB1's involvement in periodontitis.MethodsHuman periodontal mesenchymal stem cells (hPDLSCs) were exposed to LPS to mimic the inflammation in periodontitis. Following ZEB1 silencing, FX1 (an inhibitor of Bcl‐6) treatment or ROCK1 overexpression, cell viability, and apoptosis were analyzed. Alkaline phosphatase (ALP) staining, Alizarin red staining, RT‐qPCR, and western blot were performed to evaluate osteogenic differentiation and mineralization. hPDLSCs were processed for luciferase reporter assay and ChIP‐PCR to confirm the association between ZEB1 and ROCK1.ResultsThe induction of ZEB1 silencing resulted in reduced cell apoptosis, enhanced osteogenic differentiation, and mineralization. Nevertheless, these effects were significantly blunted by FX1. ZEB1 was confirmed to bind to the promoter sites of ROCK1 and regulate the ROCK1/AMPK. Whereas ROCK1 overexpression reversed the effects of ZEB1 silencing on Bcl‐6/STAT1, as well as cell proliferation and osteogenesis differentiation.ConclusionhPDLSCs displayed decreased proliferation and weakened osteogenesis differentiation in response to LPS. These impacts were mediated by ZEB1 regulating Bcl‐6/STAT1 via AMPK/ROCK1.

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Section: Introductionmentioning

confidence: 99%