The prevalence of luminal B subtype is higher in older postmenopausal women with ER+/HER2- breast cancer and is associated with inferior outcomes

Mills, Matthew; Liveringhouse, C.; Lee, Frank G.; Nanda, Ronica H.; Ahmed, Kamran A.; Washington, Iman; Thapa, Ram; Fridley, Brooke L.; Blumencranz, Peter W.; Extermann, Martine; Loftus, Loretta; Balducci, Lodovico; Díaz, Roberto

doi:10.1016/j.jgo.2020.08.007

Cited by 3 publications

(2 citation statements)

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“…Despite improved survival rates for early breast cancer (EBC) patients in the era of a multidisciplinary team approach, optimal locoregional and contemporary systemic treatments, patients with luminal B breast cancer (i.e., hormone receptor positive with high proliferation with or without HER2‐amplification) continue to have higher rates of relapse and poorer EBC‐specific survival when compared with luminal A disease. 1 , 2 Further, data from the Surveillance, Epidemiology, and End Results registry show that hormone receptor positive, HER2‐negative, or positive breast cancer accounts for 83% of those patients with known receptor status reported in 2010. 3 Studies have consistently demonstrated a prognostic role of immune cells, most frequently in regard to tumor infiltrating lymphocytes (TILs) in triple negative and HER2‐positive breast cancer.…”

Section: Introductionmentioning

confidence: 99%

“…higher rates of relapse and poorer EBC-specific survival when compared with luminal A disease. 1,2 Further, data from the Surveillance, Epidemiology, and End Results registry show that hormone receptor positive, HER2-negative, or positive breast cancer accounts for 83% of those patients with known receptor status reported in 2010. 3 Studies have consistently demonstrated a prognostic role of immune cells, most frequently in regard to tumor infiltrating lymphocytes (TILs) in triple negative and HER2-positive breast cancer.…”

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confidence: 99%

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Prognostic role of immune environment in luminal B early breast cancer

Chan

Gill²,

Chih

et al. 2023

Cancer Medicine

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The importance of the immune microenvironment in triple negative and HER2‐amplified breast cancer (BC) is well‐established; less is known about the immune environment in luminal breast cancers. We aimed to assess for the impact of immune biomarkers on BC outcome in a group of luminal B patients with archived tissue and annotated clinical information. Patients with early breast cancer (EBC) treated in a single institution over a 14‐year period, with prospectively collected data were included. Luminal B EBC patients were identified and defined into three cohorts: A: grade 2 or 3, ER & PR positive, HER2‐negative; B: Any grade, ER positive, PR and HER2‐negative (Ki67 ≥ 14% in cohorts A & B); and C: Any grade, ER or PR positive, HER2‐positive. Within each cohort, patients with a relapsed BC event (R) were compared on a 1:1 basis with a control patient (C) who remained disease‐free, balanced for key characteristics in an effort to balance the contribution of each clinical group to outcome. Archival breast, involved and uninvolved axillary nodes were assessed by immunohistochemistry for biomarkers identifying effector and suppressor immune cells, and compared between R and C. In total, 120 patients were included (80, 22, and 18 patients in cohorts A, B, and C, respectively). R were 1.5 years older (p = 0.016), with all other characteristics being balanced. Overall, there were no statistically significant differences in immune biomarkers in breast or nodal tissue of R and C. However, there was a trend toward higher levels of TILs in breast tumors of C, while GAL‐9 was consistently expressed on lymphocytes and tumor cells in all breast and nodes of C and was absent from all tissues of R. These trends in checkpoint molecule expression deserve further research.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%