The prevalence of lower urinary tract symptoms based on individual and clinical parameters in patients with multiple sclerosis

Nazari, Fatemeh; Shaygannejad, Vahid; Sichani, Mehrdad Mohammadi; Mansourian, Marjan; Hajhashemi, Valiollah

doi:10.1186/s12883-019-1582-1

Cited by 32 publications

(23 citation statements)

References 38 publications

(56 reference statements)

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“…Pads are associated with an increase in economic burden in multiple sclerosis 34. In our study, no significant differences in pad usage were found between the Tele-PFMT and Home-PFMT groups.…”

Section: Discussioncontrasting

confidence: 64%

“…Pads are associated with an increase in economic burden in multiple sclerosis. 34 In our study, no significant differ-ences in pad usage were found between the Tele-PFMT and Home-PFMT groups. On the other hand, both intervention groups were better than the control group in terms of pad usage.…”

Section: Discussioncontrasting

confidence: 58%

“…Mood disorders are associated with urgency urinary incontinence in people with multiple sclerosis 34. However, only one study assessed mood changes after PFMT in people with multiple sclerosis with urgency urinary incontinence and found that a 6-month PFMT improved anxiety and depression 40.…”

Section: Discussionmentioning

confidence: 99%

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Feasibility of Telerehabilitation-Based Pelvic Floor Muscle Training for Urinary Incontinence in People With Multiple Sclerosis: A Randomized, Controlled, Assessor-Blinded Study

Yavas

Kahraman

Sağıcı

et al. 2023

Journal of Neurologic Physical Therapy

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Background and Purpose: Urinary incontinence is a common symptom in people with multiple sclerosis. The primary aim was to investigate feasibility of telerehabilitation-based pelvic floor muscle training (Tele-PFMT) and compare its effects on leakage episodes and pad usage with home exercise-based pelvic floor muscle training (Home-PFMT) and control groups. Methods: Forty-five people with multiple sclerosis with urinary incontinence were randomized into 3 groups. Tele-PFMT and Home-PFMT groups followed the same protocol for 8 weeks, but Tele-PFMT performed exercises 2 sessions/week under a physiotherapist's supervision. The control group did not receive any specific treatment. Assessments were made at baseline, weeks 4, 8, and 12. Primary outcome measures were feasibility (compliance to exercise, patient satisfaction, and number of participants included in the study), number of leakage episodes, and pad usage. Secondary outcomes included severity of urinary incontinence and overactive bladder symptoms, sexual function, quality of life, anxiety, and depression. Results: Participant eligibility rate was 19%. Patient satisfaction and compliance to exercise were significantly higher in Tele-PFMT than in Home-PFMT (P < 0.05). No significant differences in the change of leakage episodes and pad usage were found between Tele-PFMT and Home-PFMT. No significant differences in secondary outcomes were found between PFMT groups. Participants in both the Tele-PFMT and Home-PFMT groups had significantly better scores for some measures of urinary incontinence, and overactive bladder and quality of life in compared with the control group. Discussion and Conclusions: Tele-PFMT was feasible and acceptable in people with multiple sclerosis, and this mode of delivery was associated with greater exercise compliance and satisfaction compared with Home-PFMT. However, Tele-PFMT did not exhibit superiority in terms of leakage episodes and pad usage compared with Home-PFMT. A large trial comparing Home-PFMT and Tele-PFMT is warranted. Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content, available at: http://links.lww.com/JNPT/A440).

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Section: Discussioncontrasting

confidence: 64%

Section: Discussioncontrasting

confidence: 58%

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Feasibility of Telerehabilitation-Based Pelvic Floor Muscle Training for Urinary Incontinence in People With Multiple Sclerosis: A Randomized, Controlled, Assessor-Blinded Study

Yavas

Kahraman

Sağıcı

et al. 2023

Journal of Neurologic Physical Therapy

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“…For example, a Canadian study found that males with MS had a higher relative prevalence of anxiety and depression than females at MS diagnosis ( 24 ). Further, an Iranian study found that lower urinary tract symptoms, such as intermittent urine stream, hesitancy and straining, were more common in males with MS, though relative comparisons were not made with general population controls ( 29 ). Studies have suggested that low testosterone levels are associated with increased MS risk and greater MS disability progression ( 30 , 31 ).…”

Section: Discussionmentioning

confidence: 99%

Sex and age differences in the Multiple Sclerosis prodrome

Yusuf

Wijnands²,

Karim³

et al. 2022

Front. Neurol.

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Background and objectivesLittle is known of the potential sex and age differences in the MS prodrome. We investigated sex and age differences in healthcare utilization during the MS prodrome.MethodsThis was a population-based matched cohort study linking administrative and clinical data from British Columbia, Canada (population = 5 million). MS cases in the 5 years preceding a first demyelinating event (“administrative cohort;” n = 6,863) or MS symptom onset (“clinical cohort;” n = 966) were compared to age-, sex- and geographically-matched controls (n = 31,865/4,534). Negative binomial and modified Poisson models were used to compare the rates of physician visits and hospitalizations per international classification of diseases chapter, and prescriptions filled per drug class, between MS cases and controls across sex and age-groups (< 30, 30–49, ≥50 years).ResultsIn the administrative cohort, males with MS had a higher relative rate for genitourinary-related visits (males: adjusted Rate Ratio (aRR) = 1.65, females: aRR = 1.19, likelihood ratio test P = 0.02) and antivertigo prescriptions (males: aRR = 4.72, females: aRR = 3.01 P < 0.01). Injury and infection-related hospitalizations were relatively more frequent for ≥50-year-olds (injuries < 30/30–49/≥50: aRR = 1.16/1.39/2.12, P < 0.01; infections 30–49/≥50: aRR = 1.43/2.72, P = 0.03), while sensory-related visits and cardiovascular prescriptions were relatively more common in younger persons (sensory 30–49/≥50: aRR = 1.67/1.45, P = 0.03; cardiovascular < 30/30–49/≥50: aRR = 1.56/1.39/1.18, P < 0.01). General practitioner visits were relatively more frequent in males (males: aRR = 1.63, females: aRR = 1.40, P < 0.01) and ≥50-year-olds (< 30/≥50: aRR = 1.32/1.55, P = 0.02), while differences in ophthalmologist visits were disproportionally larger among younger persons, < 50-years-old (< 30/30–49/≥50: aRR = 2.25/2.20/1.55, P < 0.01). None of the sex and age-related differences in the smaller clinical cohort reached significance (P ≥ 0.05).DiscussionSex and age-specific differences in healthcare use were observed in the 5 years before MS onset. Findings demonstrate fundamental heterogeneity in the MS prodromal presentation.

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“…Multiple Sclerosis (MS) is a chronic inflammatory disease of the CNS, affecting approximately 100,000 patients in the U.K. and 2,500,000 patients globally [59]. Interestingly, it can affect up to three times as many women as men, with an average age of onset in early adulthood [60].…”

Section: Multiple Sclerosismentioning

confidence: 99%

Retinal and Brain Microglia in Multiple Sclerosis and Neurodegeneration

Choi¹,

Guo²,

Cordeiro

2021

Cells

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Microglia are the resident immune cells of the central nervous system (CNS), including the retina. Similar to brain microglia, retinal microglia are responsible for retinal surveillance, rapidly responding to changes in the environment by altering morphotype and function. Microglia become activated in inflammatory responses in neurodegenerative diseases, including multiple sclerosis (MS). When activated by stress stimuli, retinal microglia change their morphology and activity, with either beneficial or harmful consequences. In this review, we describe characteristics of CNS microglia, including those in the retina, with a focus on their morphology, activation states and function in health, ageing, MS and other neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, glaucoma and retinitis pigmentosa, to highlight their activity in disease. We also discuss contradictory findings in the literature and the potential ways of reducing inconsistencies in future by using standardised methodology, e.g., automated algorithms, to enable a more comprehensive understanding of this exciting area of research.

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The prevalence of lower urinary tract symptoms based on individual and clinical parameters in patients with multiple sclerosis

Cited by 32 publications

References 38 publications

Feasibility of Telerehabilitation-Based Pelvic Floor Muscle Training for Urinary Incontinence in People With Multiple Sclerosis: A Randomized, Controlled, Assessor-Blinded Study

Feasibility of Telerehabilitation-Based Pelvic Floor Muscle Training for Urinary Incontinence in People With Multiple Sclerosis: A Randomized, Controlled, Assessor-Blinded Study

Sex and age differences in the Multiple Sclerosis prodrome

Retinal and Brain Microglia in Multiple Sclerosis and Neurodegeneration

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