The prevalence of isolated systolic hypertension in adult populations from the Han, Uygur and Kazakh ethnic groups in Xinjiang, China

Liu, Fen; Ma, Yun; Yang, Yi‐Ning; Zhen, Yu-Jian; Xie, Xiang; Li, Xiaomei; Ma, Xiang; Chen, Bang‐Dang; Huang, Ying; Shan, Chunfang; Gao, Xiao‐Ming

doi:10.3109/08037051.2013.838827

Cited by 15 publications

(17 citation statements)

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“…Possibly as a consequence of differences in lipid profiles, HOMA-IR of Hans was the highest, while Kazaks’ was the lowest, and an inverse relationship was observed for the Matsuda index. Those observations are in line with the prevalence of diabetes mellitus of 8.0%, 6.0%, and 3.5% in Hans, Uygurs, and Kazaks, respectively [ 7 ]. HOMA-IR [ 8 ] and the Matsuda index [ 9 ] are good predictors of diabetes mellitus development even in individuals with normal glucose tolerance [ 10 ], but it is important to highlight that they do not represent exactly the same biological processes.…”

Section: Discussionsupporting

confidence: 78%

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Different lipid profiles, insulin sensitivity, and insulin resistance among Han, Uygur, and Kazak men with normal glucose tolerance in Xinjiang, China

et al. 2018

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BackgroundThis study aimed to determine the differences in clinical parameters among Han, Uygur, and Kazak men with normal glucose tolerance.MethodsParticipants’ data from the China National Diabetes and Metabolic Disorders Study pertaining to Han, Uygur, and Kazak men from the Xinjiang province were used (n = 930). Pearson’s correlation was used to examine the relationship between HOMA-IR, Matsuda Index, and clinical characteristics.ResultsHOMA-IR of Han men was significantly higher than in Uygurs and Kazaks (P < 0.001). The Matsuda Index of Kazaks was significantly higher than that of Hans and Uygurs (P < 0.001). While Kazaks had the highest BMI, WC, SBP, and DBP; they also had the highest HDL-C and lowest TG (P < 0.001). TG of Uygurs was significantly higher than that of Hans and Kazaks (P < 0.001). In Hans and Kazaks, the TG/HDL-C ratio increased with HOMA-IR quartiles; there was no association in Uygurs. In Hans and Kazaks, the TG/HDL-C ratio decreased with Matsuda index quartiles; there was no association in Uygurs. Multivariate linear regression showed that HOMA-IR was independently associated with ethnicity, BMI and TG/HDL-C ratio (P < 0.01), while Matsuda index was independently associated with ethnicity, BMI, LDL-C levels (P < 0.001) and TG/HDL-C ratio (P < 0.001).ConclusionsIn conclusion, Han, Uygur, and Kazak men had different lipid profiles, BMI, and WC. Han men had the highest insulin resistance while Kazak men had the highest insulin sensitivity.

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Section: Discussionsupporting

confidence: 78%

“…Interestingly, Kazaks were found to have a lower prevalence of diabetes compared with Uygurs, while Hans had the highest risk of diabetes even after adjustment for body mass index (BMI) or waist circumference (WC). Kazaks were more prone to hypertension than the other two populations [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Different lipid profiles, insulin sensitivity, and insulin resistance among Han, Uygur, and Kazak men with normal glucose tolerance in Xinjiang, China

et al. 2018

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“…It is worthwhile to mention that the epidemiological profile of IDH in the current study is different from what we observed in ISH previously. In our previous study [ 36 ] we found that the prevalence of ISH was 12.4% in the Han, 11.75% in the Uygur and 11.50% in the Kazakh populations, which were higher than the prevalence of IDH in all three ethnicity groups. Moreover, ISH was more common in women than in men in Han participants, but there were no significant gender difference in the Uygur and Kazakh populations.…”

Section: Discussionmentioning

confidence: 75%

Prevalence of Isolated Diastolic Hypertension and Associated Risk Factors among Different Ethnicity Groups in Xinjiang, China

et al. 2015

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ObjectivesLittle is known about isolated diastolic hypertension (IDH) among different ethnicity groups. We aimed to investigate the prevalence and risk factors for IDH among the major ethnicity population i.e. Han, Uygur and Kazakh in Xinjiang, northwestern part of China.MethodsIn total, 14,618 adult participants (7,799 males, 6,819 females) were recruited from the Cardiovascular Risk Survey conducted during 2007 and 2010. Blood pressure, body mass index and standard lipid profile and fasting glucose level from plasma were measured.ResultsThe overall prevalence of IDH was 10.8% in the Han, 4.5% in the Uygur and 8.7% in the Kazakh populations. When stratified by gender, IDH prevalence was 9.8% in men and 6.8% in women (P<0.001). The prevalence of IDH also varied significantly with age and it was highest in those aged 35–44 yrs old (9.7%) and lowest in those over 75 yrs old (4.1%, P<0.001). Multivariate logistic regression analysis showed that overweight (OR = 1.179, 95%CI: 1.015–1.369) or obesity (OR = 1.202, 95%CI: 1.015–1.424), smoking (OR = 1.362, 95%CI: 1.156–1.604) and high total cholesterol (TC) hyperlipidemia (OR = 1.237, 95%CI: 1.074–1.423) were significantly associated with a higher prevalence of IDH. Identified risk factors for IDH differed among ethnicity groups with male gender, young age (35–44 yrs old), more coffee or tea consumption and high TC hyperlipidemia in the Han; smoking and often coffee or tea consumption in the Uygur and male gender and overweight or obesity in the Kazakh populations.ConclusionsIDH prevalence in the Han population is higher than that in the Uygur and Kazak populations in Xinjiang, northwestern part of China. Male gender, middle age, overweight or obesity, smoking and high TC hyperlipidemia appear to be relevant risk factors of IDH in adults. Different ethnicity background had different sets of risk factors for IDH.

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“…The Cardiovascular Risk Survey (CRS) is a cross-sectional, observational cohort study designed to investigate the prevalence, incidence, and risk factors for cardiovascular diseases and to determine the genetic and environmental contributions to atherosclerosis, coronary artery disease and cerebral infarction in the Han, Uygur, and Kazakh population in the Xinjiang province of West China and detailed description of study population and methods were described in the previous studies [31,32]. We used a stratified sampling method to select a representative sample of the general population of Han, Uygur and Kazakh Chinese in this region.…”

Section: Study Populationmentioning

confidence: 99%

Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008–2012)

Liu

Song

et al. 2020

Lipids Health Dis

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Background: Hyperuricemia predisposes to gout, which may result in tophi, kidney stones, or urate nephropathy even kidney failure. Many metabolic risk factors and disorders has been recognized as a key risk factor contributing to development of hyperuricemia. Aim: To determine the prevalence of hyperuricemia and its association with adiposity and dyslipidemia. Methods: We recruited non-hospitalized participants (aged ≥35 years) in Xinjiang, a northwest part of China based on the Cardiovascular Risk Survey (CRS 2008(CRS -2012. Information of general health status, seafood or internal organs intake and history of disease were obtained by using an interview-based questionnaire. The levels of serum uric acid (sUA) and creatinine and lipid profiles were measured. A multivariate logistic regression model was performed to assess the association between prevalence of hyperuricemia and adiposity and dyslipidemia. (Continued on next page)Results: This study recruited 16,611 participants, and 14,618 was included (mean age of 50.5 ± 12.6 years, 46.6% was males). The study population comprised three ethnic groups with 39.4% of Han, 32.6% of Uygur and 28% of Kazakh Chinese. The overall prevalence of hyperuricemia was 9.1% (95% CI: 8.6 to 9.6) and it was11.8% in men was 6.7% in women. The three ethnic groups also had different hyperuricemia prevalence with 15.4% in Han, 4.6% in Uygur and 5.5% in Kazakh Chinese, which corresponding to a respective mean sUA levels of 306.2 ± 86.9, 249.4 ± 76.1 and 259.8 ± 78.7 μmol/L. Participants with diabetes, hypertension or hypertriglyceridemia and higher blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), fasting blood glucose (FBG), triglycerides (TG), total cholesterol (TC) had higher levels of sUA (P < 0.001 respectively). Multivariate logistic regression analysis revealed that age, gender, ethnicity, drinking, obesity, waist circumference, TG (≥2.26 mmol/L), TC (≥6.22 mmol/L) are major risk factors for hyperuricemia. Compared to the 35-44-year age group [adjusted odds ratio (AOR) = 1], the risk of hyperuricemia increased 1.61-fold in the 65-74-year age group (AOR = 1.61, 95% CI: 1.34-1.91; P < 0.001), and 1.71-fold in the 75-and older age group (AOR = 1.71, 95% CI: 1.27-2.29; P < 0.001). There was a 1.45-fold higher risk of hyperuricemia in men (AOR = 1.45, 95% CI: 1.24-1.68; P < 0.001) compared to women. Further, the risk of hyperuricemia increased significantly with drinking (AOR = 1.36; 95% CI: 1.16-1.61; P < 0.001), overweight (AOR = 1.25; 95% CI: 1.06-1.48; P = 0.01), obesity (AOR = 1.28; 95% CI: 1.10-1.49; P < 0.001), waist circumference (AOR = 1.48; 95% CI: 1.24-1.78; P < 0.001), TC (≥6.22 mmol/L, AOR = 1.45; 95% CI: 1.19-1.75; P < 0.001), TG (≥2.26 mmol/L, AOR = 2.74; 95% CI: 2.39-3.14; P < 0.001). Conclusions: These findings documented that the hyperuricemia is prevalent in the economically developing regions of northwest China. Hyperuricemia is associated with advanced age, male ender and general metabolic and cardiovascular risk factors. Obesity and dyslip...

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The prevalence of isolated systolic hypertension in adult populations from the Han, Uygur and Kazakh ethnic groups in Xinjiang, China

Cited by 15 publications

References 9 publications

Different lipid profiles, insulin sensitivity, and insulin resistance among Han, Uygur, and Kazak men with normal glucose tolerance in Xinjiang, China

Different lipid profiles, insulin sensitivity, and insulin resistance among Han, Uygur, and Kazak men with normal glucose tolerance in Xinjiang, China

Prevalence of Isolated Diastolic Hypertension and Associated Risk Factors among Different Ethnicity Groups in Xinjiang, China

Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008–2012)

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