The prevalence of interatrial septal openings in newborns and predictive factors for spontaneous closure

Ozcelik, Nazire; Atalay, Semra; Tutar, Ercan; Ekici, Filiz; Atasay, Begüm

doi:10.1016/j.ijcard.2005.05.023

Cited by 19 publications

(19 citation statements)

References 13 publications

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“…The median age of the patients with spontaneous closure was 2.25 years, and the maximum age at spontaneous closure was 3.9 years. Our study confirmed previous reports ( 10 , 11 ) indicating that spontaneous closure can occur beyond infancy. Therefore, the window of opportunity for selective surgery can be determined according to patient age.…”

Section: Discussionsupporting

confidence: 93%

The Clinical Course of Patients With Atrial Septal Defects

et al. 2016

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BackgroundAtrial septal defect (ASD) is a common congenital heart disease.ObjectivesThe aim of this study was to assess the clinical course of ASD, as well as its frequency of spontaneous closure and regression of diameter.MethodsIn a study conducted from 2000 to 2011, 192 consecutive patients with an isolated ASD were followed up regularly with periodic echocardiographic evaluations according to a standardized protocol. The study was conducted in two series of patients: infants and children and adults. Infants were classified into three groups based on ASD diameter: small (≤ 5 mm), medium (6 - 9 mm), and large (> 9 mm). In the same manner, the ASD size in children and adults was categorized into three groups: small (≤ 10), medium (10 - 20 mm), and large (> 20 mm).ResultsThe patients consisted of 76 (39.6%) males and 116 (60.4%) females. The mean age of patients at diagnosis was 16.12 ± 15.66 years (range 1 week - 75 years). The mean follow-up duration was 70 ± 9 months (range: 25 - 119 months). The most prevalent age group was adult patients (> 20 years), and most ASDs were of medium size (1 - 2 cm). The most common complication was mild pulmonary hypertension (31 cases, 16.2%), and Eisenmenger phenomenon was the rarest complication (2 cases, 1%). Overall spontaneous closure of ASD occurred in 42 (21.9%) cases. Spontaneous closure in cases with small defects occurred in 18 of 22 (81%) infants and 24 of 81 children > 1 years of age. Regression of ASD size occurred in 2 (9.5%) infants and 3 (3.7%) children. No spontaneous closure was observed in cases with a defect size > 10 mm, and no spontaneous occlusion was detected in adolescents or adults. Seventy-two percent (n = 139) of patients needed surgical repair or transcatheter closure of the ASD.ConclusionsIt is concluded that atrial septal defects < 6 mm typically close spontaneously, and ASDs measuring 6 - 9 mm may regress in infants and children. An ASD > 1 cm has little chance of spontaneous closure and may need surgical or device closure. ASD diameter and age at diagnosis are the most important predictors of spontaneous closure and the need for possible surgical or device closure.

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Section: Discussionsupporting

confidence: 93%

The Clinical Course of Patients With Atrial Septal Defects

et al. 2016

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“…16,17 Ozcelik et al 16 also reported that, for those with defects of 7 mm and above, the rate of spontaneous closure went down to 50%. 16 Radzic et al 5 and Ozcelik et al, 16 however, stated that no patients with defects of 8 mm and above underwent closure, whereas we observed 7.5% spontaneous closure in those patients, with 2 of these patients having aneurysms. As with previous studies, 3,11 we found no influence of heart failure on closure.…”

Section: Discussionmentioning

confidence: 98%

Outcome for patients with isolated atrial septal defects in the oval fossa diagnosed in infancy

Demir

Öztunç

Eroğlu

et al. 2008

CTY

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“…Several studies have reported that ASO size [13,14,15,16] and the age at diagnosis [17,18] are predictors of ASO closure. In the present study, no association was observed between ASO size and time of closure.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics and Outcome of Incidental Atrial Septal Openings in Very Low Birth Weight Infants

Lee¹,

Lim²,

Kim³

et al. 2013

Neonatology

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Background: Atrial septal openings (ASOs) are very common in premature infants. Objective: The study aimed to evaluate the prevalence and natural course of ASOs in very low birth weight (VLBW) infants diagnosed in the first week of life and the association of ASOs with various clinical factors. Methods: We retrospectively reviewed the medical records of 217 infants born with a weight of <1,500 g between January 2007 and December 2011. Echocardiography was conducted within the first week of life in all infants. Clinical factors were compared between infants with ASO and those with an intact atrial septum. ASO closure was confirmed by echocardiography at the 3-month follow-up and subsequently every 6 months. Results: The incidence of ASOs was 40.3% in VLBW infants. Patent ductus arteriosus (PDA) was associated with a higher incidence of ASO in a multivariate analysis (OR 4.005, 95% CI 2.015-7.960, p < 0.001), and PDA was a predictor of early ASO closure. The rate of oxygen requirement for at least 28 days was higher in infants with ASO, whereas oxygen dependency at 36 weeks' postmenstrual age did not differ between the infant groups. The mean time of closure was 5.8 ± 7.1 months of age (range 0-36). All followed infants showed spontaneous closure within 3 years. Conclusions: ASOs occur at a relatively high incidence in VLBW infants, but most of these close spontaneously within 3 years. PDA was predictive of ASO at the first echocardiography but did not delay ASO closure. The ASOs in VLBW infants were not a significant cause of concern.

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The prevalence of interatrial septal openings in newborns and predictive factors for spontaneous closure

Cited by 19 publications

References 13 publications

The Clinical Course of Patients With Atrial Septal Defects

The Clinical Course of Patients With Atrial Septal Defects

Outcome for patients with isolated atrial septal defects in the oval fossa diagnosed in infancy

Clinical Characteristics and Outcome of Incidental Atrial Septal Openings in Very Low Birth Weight Infants

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