The prevalence of insomnia and restless legs syndrome among Japanese outpatients with rheumatic disease: A cross-sectional study

Urashima, Kayoko; Ichinose, Kunihiro; Kondo, Hideaki; Maeda, Takahiro; Kawakami, Atsushi; Ozawa, Hiroki

doi:10.1371/journal.pone.0230273

Cited by 12 publications

(7 citation statements)

References 42 publications

(50 reference statements)

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“…Our global sleep score was not the only measure deviating from previously published data. Insomnia has been studied in the context of RA, with frequencies as high as 63% 20 21. Although the mean disease duration was longer in the study by Mustafa et al 20 compared with our present study (7.8 years vs 4.0 years), this is not enough to explain the differences, as we in our study did not observe that the rate of insomnia changed with disease duration.…”

Section: Discussioncontrasting

confidence: 81%

Sleep problems in rheumatoid arthritis over 12 years from diagnosis: results from the Swedish EIRA study

et al. 2022

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ObjectiveMost studies of rheumatoid arthritis (RA) and sleep have focused on established RA. We here investigate sleep quality and sleep duration in patients with newly diagnosed RA and during 1–12 years after diagnosis.MethodsData were collected on sleep 1–12 years after diagnosis from patients diagnosed 1998–2018 in the Swedish study Epidemiological Investigation of RA. Six sleep domains (sleep problems, non-restorative sleep, insomnia, insufficient sleep, sleep quality perceived as poor and sleep considered a health problem); a global sleep score and time spent in bed were estimated. Using logistic regression, ORs were calculated for each sleep outcome by disease duration. We explored whether pain (low (Visual Analogue Scale=0–20 mm, reference), intermediate=21–70, high=71–100) or functional impairment (Health Assessment Questionnaire>1.0) was associated with problems.ResultsWe had sleep data on 4131 observations (n=3265 individuals). Problems with ≥1 sleep domain (global sleep score) was reported in 1578 observations (38%) and increased with disease duration (OR 1.04, 95% CI 1.02 to 1.07). Median time in bed was 8 hours (Q1-Q3: 7.5–9.0). High-grade pain increased the likelihood of sleep problems ~3–9 fold, and increased functional impairment ~4–8 fold.ConclusionIn this cohort of newly diagnosed patients with RA with access to the current treatment from diagnosis, we did not find any major problems with sleep, and existing sleep problems related mainly to pain and reduced function. Treatment of sleep problems in RA should be guided towards treating the underlying problem causing the sleep disturbance.

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Section: Discussioncontrasting

confidence: 81%

Sleep problems in rheumatoid arthritis over 12 years from diagnosis: results from the Swedish EIRA study

et al. 2022

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“…Under chronic inflammation conditions like rheumatic heart disease, administration of iron has been argued to not be effective due to iron trapping within the macrophages and hepatocytes. This is manifested as higher levels of ferritin [ 19 ]. COVID-19 is also an inflammatory condition that can affect iron homeostasis [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

New-onset restless leg syndrome in a covid-19 patient: a case report with literature review

et al. 2021

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Restless leg syndrome (RLS) is a sleep disorder characterized by the sudden urge to move the lower limbs during periods of rest accompanied by an unpleasant sensation like tingling or burning in the legs. Often, this urge is partially relieved by the movement of legs. However, it causes disturbance of sleep leading to daytime fatigue. Herein, we present an unusual case of new-onset of restless leg syndrome in a COVID-19 infected patient who presented three weeks after an uncomplicated delivery via caesarean section. The patient was managed with sleep hygiene measures, oral iron and vitamin C tablets apart from general COVID-19 management medications, subsequently leading to significant improvements. Here we have discussed possible associated factors, pathophysiological mechanisms and management of RLS in the case of COVID infected individuals.

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“…Several studies in the literature have proven the presence of RLS in patients with RA (10)(11)(12)(13)(14). In this study, we aimed to show the frequency of IDA and the relationship of iron deficiency with RLS in RA patients.…”

Section: Introductionmentioning

confidence: 96%

Restless Leg Syndrome and Sleep Disorders in Patients with Rheumatoid Arthritis and Its Relation with Anemia Parameters

Demir

Küçük

Altaş

et al. 2021

Acta Med. (Hradec Kralove, Czech Repub.)

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Objectives: We aimed to investigate the prevalence of restless legs syndrome (RLS) and sleep disorders in patients with rheumatoid arthritis (RA), and the association of iron deficiency with them. Materials and methods: The study included 72 patients with RA (59 females, 13 males), and 50 healthy control subjects (57 females, 15 males). Assessments were made using the International RLS Rating Scale, Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale, Fatigue Severity Scale (FSS), Beck anxiety and depression index and the SF-36 quality of life scores. Results: We found that the frequency of RLS in RA patients was 29.1% and 13.8% in healthy control (p = 0.021). RA patients had 44.4% iron deficiency and 5.5% anemia of chronic disease. We found that 52.3% of patients with iron deficiency had RLS. There was an independent relationship between present of RLS and FSS (Beta [β] = 0.317, p = 0.005) and total iron binding capacity (TIBC) (β = 0.244, p = 0.031). There was an independent relationship between RLS severity score and PSQI (β = 0.264, p = 0.025) and social functionality (β = 0.302, p = 0.009). Conclusion: The prevalence of iron deficiency is high in RA in the developing countries. Analysis obtained in patients with RA is suggestive of an association between iron deficiency and increased frequency of RLS. The presence of RLS in patients with RA negatively affects sleep quality, psychiatric status, and quality of life of patients with RA. TIBC value may be a predictive marker for early detection of RLS in patients with RA.

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The prevalence of insomnia and restless legs syndrome among Japanese outpatients with rheumatic disease: A cross-sectional study

Cited by 12 publications

References 42 publications

Sleep problems in rheumatoid arthritis over 12 years from diagnosis: results from the Swedish EIRA study

Sleep problems in rheumatoid arthritis over 12 years from diagnosis: results from the Swedish EIRA study

New-onset restless leg syndrome in a covid-19 patient: a case report with literature review

Restless Leg Syndrome and Sleep Disorders in Patients with Rheumatoid Arthritis and Its Relation with Anemia Parameters

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