The prevalence of indoor allergens in the Baltimore area: House dust-mite and animal-dander antigens measured by immunochemical techniques

Lind, Peter; Norman, Philip S.; Newton, Mary R.; Løwenstein, Henning; Schwartz, B.

doi:10.1016/0091-6749(87)90005-4

Cited by 34 publications

(16 citation statements)

References 21 publications

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“…Horse allergen seems to be as tenacious as cat allergen, enabling it to be transferred on clothing 9. Such carriage probably explains the presence of horse allergen in domestic dust samples from urban environments 10. Determining the cause of case 2's symptoms was difficult because the patient presented with late phase asthmatic symptoms that occurred many hours after exposure to the allergen 5.…”

Section: Discussionmentioning

confidence: 99%

Lesson of the week: Horse allergy in children

Roberts

Lack²

2000

BMJ

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Section: Discussionmentioning

confidence: 99%

Lesson of the week: Horse allergy in children

Roberts

Lack²

2000

BMJ

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“…The results were given in titers showing the amount of allergen in the patient's home (4). The results were given in titers showing the amount of allergen in the patient's home (4).…”

Section: Methodsmentioning

confidence: 99%

Immunotherapy with dog and cat extracts in children

Bertelsen¹,

Andersen²,

Christensen³

et al. 1989

Allergy

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Hypersensitivity to dogs and cats causes asthma in many children. In this open controlled clinical study we wanted to establish whether immunotherapy can be recommended as a supplement to conventional medical therapy in dog- and cat-induced asthma in children. Twenty-seven children with mean age 10 7/12 years and with allergy to dog or cat according to anamnesis, skin prick test (SPT), specific IgE (RAST) and bronchial provocation test (BPT) entered the study. On the basis of age and bronchial sensitivity they were randomly allocated to either immunotherapy with dog or cat extract (active group, n = 14) or conventional medical therapy (control group, n = 13). Immunotherapy comprised subcutaneous injections with an alum-adsorbed depot extract (Alutard-SQ), and a maintenance dose of 100,000 SQ-U or the maximum tolerated dose. Before entering the study and after 9 months' therapy the patients were evaluated by BPT, SPT, RAST - and IgG4 analyses. The active group showed statistically significant change in bronchial tolerance (P less than 0.02), whereas no such change was found in the control group (P greater than 0.05). The change in skin sensitivity was significantly greater in the active group than in the control group (P less than 0.05), whereas no significant differences were found in RAST and IgG4. However, a significant (P = 0.05) increase in IgG4 was seen in the active but not in the control group. Frequency and degree of side effects in this study were acceptable.

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“…In particular, antigenic determinants on the Der I al lergens have been analyzed in detail with the use of several series of monoclonal antibodies [28][29][30], and sensitive immunoassays developed for measuring the Der I allergens [31][32][33] have made it much easier to evaluate dust mite allergen levels in houses [34,35]. However, the Der II allergens seems to have been less investigated than the Der I allergens, because they have only been purified in relatively small quantities.…”

Section: Discussionmentioning

confidence: 99%

Comparative Analysis of Physicochemical and Immunochemical Properties of the Two Major Allergens from <i>Dermatophagoides pteronyssinus </i>and the Corresponding Allergens from <i>Dermatophagoides farinae</i>

Yasueda¹,

Mita²,

Yui³

et al. 1989

Int Arch Allergy Immunol

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Two major allergens, DPI (Der p I) and DP2 (Der p II), were isolated from the whole culture extract of Dermatophagoides pteronyssinus, and the physicochemical and immunochemical properties of these allergens were compared with those of the corresponding allergens from Dermatophagoides farinae, DF1 (Der f I)and DF2 (Der f II).On sodium dodecyl sulfate-polyacrylamide gel electrophoresis, polyacrylamide gel isoelectric focusing and amino acid analysis, both DP1 and DP2 were demonstrated to have close physicochemical similarity with DF1 and DF2, respectively. On immunodiffusion with the use of rabbit antisera, the two Der I allergens showed the reaction of typical partial identity, while the two Der II allergens showed the reaction of almost complete identity. Radioallergosorbent test (RAST) and RAST absorption experiments with the use of sera from mite-allergic patients showed that human IgE antibody response to the Der I allergens was directed against both cross-reactive and species-specific determinants. In contrast, IgE antibodies to the Der II allergens were demonstrated to react almost completely to cross-reactive determinants.

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The prevalence of indoor allergens in the Baltimore area: House dust-mite and animal-dander antigens measured by immunochemical techniques

Cited by 34 publications

References 21 publications

Lesson of the week: Horse allergy in children

Lesson of the week: Horse allergy in children

Immunotherapy with dog and cat extracts in children

Comparative Analysis of Physicochemical and Immunochemical Properties of the Two Major Allergens from <i>Dermatophagoides pteronyssinus </i>and the Corresponding Allergens from <i>Dermatophagoides farinae</i>

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