The Prevalence of Hypopharynx Findings Associated with Gastroesophageal Reflux in Normal Volunteers

Hicks, Douglas M.; Ours, Tina M.; Abelson, Tom I.; Vaezi, Michael F.; Richter, Joel E.

doi:10.1016/s0892-1997(02)00132-7

Cited by 255 publications

(217 citation statements)

References 18 publications

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“…According to Noordzig et al [2002] study none of the laryngeal signs correlated with LPR severity. However, the specificity of these findings for LPR diagnosis is questionable because an earlier study by Hicks et al [2002] [24] [24] In our study the mean RFS pre treatment was 6.56 ± 1.8 and post treatment it was 2.4 ± 1.61. "p" value was found to be 0.001 which was significant.…”

Section: Discussionmentioning

confidence: 53%

Hoarseness and Laryngopharyngeal Reflux: A Prospective Study

Pullarat¹

2017

IOSR JDMS

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Section: Discussionmentioning

confidence: 53%

Hoarseness and Laryngopharyngeal Reflux: A Prospective Study

Pullarat¹

2017

IOSR JDMS

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“…Hicks et al (8) carried out larynx endoscopic investigations of 105 normal volunteers and observed alterations on larynx in 86% of the casuistic. But, these authors did not exclude of the study, individuals using alcohol and tobacco, both factors that can cause lesions on larynx (18,22,32) .…”

Section: Discussionmentioning

confidence: 99%

Gastroesophageal reflux disease and vocal disturbances

Henry

Martins

Lerco

et al. 2011

Arq. Gastroenterol.

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CONTEXT: Gastroesophageal reflux disease is a chronic disease in which gastroduodenal contents reflux into the esophagus. The clinical picture of gastroesophageal reflux disease is usually composed by heartburn and regurgitation (typical manifestations). Atypical manifestations (vocal disturbances and asthma) may also be complaint. OBJECTIVE: To analyse the clinical, endoscopic, manometric and pHmetric aspects of patients suffering from gastroesophageal reflux disease associated with vocal disturbances. METHODS: Fifty patients with gastroesophageal reflux disease were studied, including 25 with vocal disturbances (group 1 - G1) and 25 without these symptoms (group 2 - G2). All patients were submitted to endoscopy, manometry and esophageal pHmetry (2 probes). The group 1 patients were submitted to videolaryngoscopy. RESULTS: Endoscopic findings: non-erosive reflux disease was observed in 95% of G1 patients and 88% of G2. Videolaryngoscopy: vocal fold congestion, asymmetry, nodules and polyps were observed in G1 patients. Manometric findings: pressure in the lower esophageal sphincter (mm Hg): 11.6 ± 5.2 in G1 and 14.0 ± 6.2 in G2 (P = 0.14); pressure in the upper esophageal sphincter (mm Hg): 58.4 ± 15.9 in G1 and 69.5 ± 30.7 in the controls. pHmetric findings: De Meester index: 34.0 ± 20.9 in G1 and 15.4 ± 9.4 in G2 (P<0.001); number of reflux episodes in distal probe: 43.0 ± 20.4 in G1 and 26.4 ± 17.2 in G2 (P = 0.003); percentage of time with esophageal pH value lower than 4 units (distal sensor): 9.0% ± 6.4% in G1 and 3.4% ± 2.1% in G2 (P<0.001); number of reflux episodes in proximal probe: 7.5 ± 10.9 in G1 and 5.3 ± 5.7 in G2 (P = 0.38); percentage of time with esophageal pH values lower than 4 units (Proximal probe): 1.2 ± 2.7 in G1 and 0.5 ± 0.7 in G2 (P = 0.21). CONCLUSIONS: 1) The clinical, endoscopic, and manometric findings observed in patients with vocal disturbance do not differ from those without these symptoms; 2) gastroesophageal reflux intensity is higher in patients with vocal disturbance; 3) patients without vocal disturbance can also present reflux episodes in the proximal probe.

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“…Moreover, elderly and debilitated patients who are at highest risk for foreign material aspiration are often poor candidates for lung biopsy. Clinical scenarios where biopsy is not the first option and/or the pathology is not definitive should lead to evaluation of GERD (table 2) [97][98][99][100][101][102][103][104][105][106][107][108]. Combined multi-channel oesophageal impedance and pH-metry probe is the test of choice, detecting both acid and non-acid reflux with high sensitivity and specificity [99], as well as identifying proximal reflux with the potential for aspiration.…”

Section: Bronchiolitis Obliterans In Lung Transplant Recipientsmentioning

confidence: 99%

“…Visualisation of the respiratory mucosa may support the diagnosis of oesophageal reflux if posterior laryngeal inflammation and/or contact granulomas of the vocal cords are seen [114]; however, findings are often nonspecific as shown by one laryngoscopic study of normal volunteers where 86% had at least one sign associated with reflux [100]. Bronchoscopy has the advantage of allowing lung biopsy and bronchoalveolar lavage (BAL); the latter technique is useful in excluding infectious agents such as NTM.…”

Section: Bronchiolitis Obliterans In Lung Transplant Recipientsmentioning

confidence: 99%

Gastro-oesophageal reflux disease and non-asthma lung disease

Morehead¹

2009

European Respiratory Review

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Gastro-oesophageal reflux disease (GERD) is a common disorder in Western countries, and its relationship to airways disorders (e.g. asthma) has been well established. Lung diseases other than asthma have also been associated with GERD, but the nature and scope of this relationship has not been fully defined. Diseases that have been associated with GERD include bronchiolitis syndromes, idiopathic pulmonary fibrosis, scleroderma and nontubercular mycobacterial infection.Diagnostic evaluation centres upon proving both reflux and pulmonary aspiration, which may be accomplished in some cases by lung biopsy. However, in many cases a compatible clinical and radiographic picture coupled with proof of proximal reflux by combined oesophageal probe testing may suffice for a provisional diagnosis and allow institution of anti-reflux measures.Proton-pump inhibitors are the medications of choice for GERD; other interventions shown to reduce reflux are weight loss, elevation of the head of the bed and avoidance of recumbency after meals. However, acid suppression therapy does not address non-acid reflux that may be important in disease pathogenesis in select patients, and lifestyle modifications often fail.Laparoscopic fundoplication is the procedure of choice for medically refractory GERD with excellent short-term results with respect to respiratory symptoms associated with GERD; however, long-term studies document a significant percentage of patients requiring ongoing acid suppression therapy.

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The Prevalence of Hypopharynx Findings Associated with Gastroesophageal Reflux in Normal Volunteers

Cited by 255 publications

References 18 publications

Hoarseness and Laryngopharyngeal Reflux: A Prospective Study

Hoarseness and Laryngopharyngeal Reflux: A Prospective Study

Gastroesophageal reflux disease and vocal disturbances

Gastro-oesophageal reflux disease and non-asthma lung disease

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