The prevalence of hyperprolactinaemia in overt and subclinical hypothyroidism

Hekimsoy, Zeliha; Kafesçiler, Sabriye Özkaya; Güçlü, Feyzullah; Özmen, Bilgin

doi:10.1507/endocrj.k10e-215

Cited by 46 publications

(33 citation statements)

References 14 publications

(31 reference statements)

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“…This is one of the reasons for the slightly higher incidence of FN using the colloid method compared with the dye method in the present study. The success rate of SLN detection was lower using the blue dye (74%-87%) than using the radioisotope method (87%-100%), and the success rate (94%-100%) increased when the two techniques were used together (25,26,27). In the present study, SLN were detected in 49 patients in the group treated with ISB (94.23%).…”

Section: Discussioncontrasting

confidence: 46%

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Comparison of the accuracy of isosulfan blue and technetium-99m lymphoscintigraphy to determine axillary lymph node metastasis in breast cancer

Albuz¹,

Akkurt²,

Ayan³

et al. 2017

Med J Islamic World Acad Sci

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Breast cancer is the most common malignant neoplasm in women, accounting for nearly 31% of all female cancers (1-3). Most patients in developed countries are diagnosed with stages I and II, of which about 65% have no axillary lymph node (ALN) metastasis (4). However, complications such as edema, seroma, injuries of veins and nerves passing through ALN, limitation of arm movements, and pain are noted (5-7). The presence and number of axillary metastatic lymph nodes are the most important prognostic factors in breast cancer (4-7). The results of clinical evaluation of the axillary region are often misleading in approximately one third of patients (7-11). It was determined in 1930 that the lymphatic drainage of the primary tumor was directed to a focal point, from where it spread to other lymph nodes. This first station of lymph node metastasis was called sentinel lymph node (SLN) (12,13). Systematic studies of breast cancer have shown that cancer spreads to one or more SLNs before spreading to other ALNs (14,15). The present study aimed to evaluate axillary sentinal lymph node metastasis for breast cancer diagnosis. The effectiveness of technetium-99 m sulfur colloid, isosulfan blue (ISB), and concomitant use of technetium-99 m sulfur colloid and ISB was compared. SUMMARYThis study aimed to compare the efficiency of isosulfan blue (ISB) and colloid methods in determining metastatic conditions of axillary lymph node in sentinel lymph node biopsy (SLNB). This prospective study was performed between April 2005 and July 2009 at Gulhane Medical Faculty, Department of General Surgery. A total of 102 female patients diagnosed with breast cancer were enrolled in the clinic of Gulhane School of Medicine. According to the diagnostic protocols of SLN, the patients were divided into three groups as follows: ISB (group I), colloid (group II), and ISB and colloid (group III). SLN was identified in 49 of 52 patients (94.2%) in the ISB group; the sensitivity, specificity, negative predictive value (NPV), positive predictive value (PPV), and false negativity (FN) ratio were found to be 90.9%, 75.8%, 96.1%, 55.5%, and 9.1%, respectively. On the contrary, the sentinel lymph node was identified in 38 of 38 (100%) patients in the colloid group; the sensitivity, specificity, PPV, NPV, and FN were found to be 88.2%, 100%, 100%, 91.3%, and 11.8%, respectively. In ISB and colloid groups; SLN was identified in 12 of 12 (100%) patients in the ISB and colloid groups; the sensitivity, specificity, PPV, NPV, and FN were found to be 100%, 100%, 100%, and 0%, respectively. This study showed that the combined methods applied to heterogeneous groups of patients for SLNB in breast cancer cases were minimally invasive and effective and hence could be used for evaluating nodal metastases.

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Section: Discussioncontrasting

confidence: 46%

“…Dissection of levels I and II lymph nodes in breast cancer was suggested to be curable at the consensus conference of the National Cancer Institute of the United States in 1990 (4). In addition, studies showed that colloid and isosulfan blue methods achieved higher success rates when applied together (25,26,27).…”

Section: Discussionmentioning

confidence: 99%

Comparison of the accuracy of isosulfan blue and technetium-99m lymphoscintigraphy to determine axillary lymph node metastasis in breast cancer

Albuz¹,

Akkurt²,

Ayan³

et al. 2017

Med J Islamic World Acad Sci

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“…BGT %15-50 ve DM %15-30 arasında bildirilmektedir. Yeni tanı almış yetmiş iki akromegali hastasıyla yapılan bir çalışmada BGT %18,1 ve DM %27,8 olarak bulunmuştur [13]. Görüldüğü üzere hastalarımızdaki diyabet gelişim oranı literatür bilgileri ile uyumludur.…”

Section: Discussionunclassified

Evaluation of the metabolic characteristics of patients with Acromegaly

Kılınç

Pekkolay²,

Gözel³

et al. 2016

J Clin Exp Invest

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Objective: Acromegaly is a syndrome characterized by growth hormone (GH) and insulin like growth factor-1 (IGF-1) over secretion. It was aimed to sharing detected metabolic disorders of the patients with acromegaly who have been under follow-up at our clinic. Methods:One hundred five patients, who were diagnosed as acromegaly in our clinic between 2010 and 2015, were enrolled to the study. The age, gender, involvement feature additional systemic and metabolic diseases were recorded and laboratory findings.Results: A total of 105 patients included in the study, 56 women (53.3%) and 49 men (46.7%), respectively. Patient's' ages ranged 23-78 (mean 42.1±16.7). 34 patients (32.3%), hypertension in 20 (19.04%), diabetes mellitus, and is 11 (10.4%) had impaired glucose tolerance. Conclusion:Somatic disfigurement (hand and foot enlargement etc.) is the major characteristic of the disease but the prognosis is determined by cardiovascular, respiratory and metabolic complications. In acromegaly, hypertension and diabetes are common, cardiovascular disease is the principal cause of death. We believe that our study will contribute to the determination of our country's data. J Clin Exp Invest 2015; 6 (4): 382-386 Key words: Acromegaly, hypertension, diabetes Hipofiz glandında oluşan ve otonom çalışan bir somatotrof adenoma bağlıdır. %95 ön hipofizden aşırı büyüme hormonu salınımına bağlıdır. Hipofiz

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“…It has been reported that mild hyperprolactinemia may develop in patients with obvious and subclinical primary hypothyroidism (40% and 22%, respectively) (27). However, PRL levels are determined to be normal in many hypothyroid patients (28).…”

Section: Pathological Causesmentioning

confidence: 99%