The prevalence of hyperprolactinaemia and association with markers of autoimmune thyroid disease in survivors of the Whickham Survey cohort

Vanderpump, Mark; French, Joyce M.; Appleton, David R.; Tunbridge, W. M. G.; Kendall‐Taylor, P.

doi:10.1046/j.1365-2265.1998.00343.x

Cited by 50 publications

(32 citation statements)

References 23 publications

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“…No new imaging abnormalities were seen during extended follow-up. There was no clinical evidence of autoimmunity demonstrated in our cohort, which is in agreement with other published data (11,14,15).…”

Section: Discussionsupporting

confidence: 93%

Ten-Year Clinical Follow-Up of a Cohort of 51 Patients with Macroprolactinemia Establishes It as a Benign Variant

Wallace

Satti

Courtney

et al. 2010

The Journal of Clinical Endocrinology &Amp; Metabolism

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Section: Discussionsupporting

confidence: 93%

Ten-Year Clinical Follow-Up of a Cohort of 51 Patients with Macroprolactinemia Establishes It as a Benign Variant

Wallace

Satti

Courtney

et al. 2010

The Journal of Clinical Endocrinology &Amp; Metabolism

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“…Of particular interest is the normal 24 hour mean prolactin profile reported in males with primary hypothyroidism (7)(8)(9)(10)(11).…”

Section: Discussionmentioning

confidence: 99%

Inhibin B Levels in Hypothyroid Males

Donnelly

Tan

Winch

2013

Thyroid

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Background: The primary role of inhibin B is the regulation of gametogenesis via negative feedback on the production of follicle stimulating hormone (FSH) by the pituitary. Methods: We studied 14 males with primary hypothyroidism due to various etiologies to determine if they exhibited hypogonadotrophic hypogonadism involving the reproductive segment of the gonadotrophic axis. Levels of inhibin B, FSH, luteinizing hormone, testosterone, free thyroxine, and thyrotropin were measured. Results: The mean level of inhibin B in males with primary hypothyroidism was found to be approximately half that of normal males. The FSH level remained within the normal range and no reciprocal increase was observed as occurs in other conditions with reduced inhibin B. Conclusions: Our results indicate that primary hypothyroidism has a significant effect on inhibin B levels without reciprocal increase in FSH, which is consistent with a hypogonadotrophic hypogonadal state affecting the reproductive segment of the gonadotrophic axis.

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“…In a large survey among 1877 subjects, hyperprolactinemia was found not to be associated with AITD (37).…”

Section: Paritymentioning

confidence: 92%

The environment and autoimmune thyroid diseases

2004

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Genetic factors play an important role in the pathogenesis of autoimmune thyroid disease (AITD) and it has been calculated that 80% of the susceptibility to develop Graves' disease is attributable to genes. The concordance rate for AITD among monozygotic twins is, however, well below 1 and environmental factors thus must play an important role. We have attempted to carry out a comprehensive review of all the environmental and hormonal risk factors thought to bring about AITD in genetically predisposed individuals. Low birth weight, iodine excess and deficiency, selenium deficiency, parity, oral contraceptive use, reproductive span, fetal microchimerism, stress, seasonal variation, allergy, smoking, radiation damage to the thyroid gland, viral and bacterial infections all play a role in the development of autoimmune thyroid disorders. The use of certain drugs (lithium, interferon-a, Campath-1H) also increases the risk of the development of autoimmunity against the thyroid gland. Further research is warranted into the importance of fetal microchimerism and of viral infections capable of mounting an endogenous interferon-a response.European Journal of Endocrinology 150 605-618

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The prevalence of hyperprolactinaemia and association with markers of autoimmune thyroid disease in survivors of the Whickham Survey cohort

Cited by 50 publications

References 23 publications

Ten-Year Clinical Follow-Up of a Cohort of 51 Patients with Macroprolactinemia Establishes It as a Benign Variant

Ten-Year Clinical Follow-Up of a Cohort of 51 Patients with Macroprolactinemia Establishes It as a Benign Variant

Inhibin B Levels in Hypothyroid Males

The environment and autoimmune thyroid diseases

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