The Prevalence of Human Papillomavirus Infection in Korean Non-Small Cell Lung Cancer Patients

Park, Moo Suk; Chang, Yoon Soo; Shin, Ju Hye; Kim, Dae Joon; Chung, Kwansoo; Shin, Dong Hwan; Moon, Jin Wook; Kang, Shin Myung; Hahn, ChangHoon; Kim, Young Sam; Chang, Joon; Kim, Sung Kyu; Kim, Se Kyu

doi:10.3349/ymj.2007.48.1.69

Cited by 34 publications

(19 citation statements)

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“…There is the possibility that the use of nested-ISH could have led to over-amplification of HPV DNA. A recent Korean study using PCR methods for detecting HPV 16, 18 and 33 showed low prevalence of the high-risk genotypes averaging 10% and no association with smoking status or sex (30). A study from India that looked at 40 patients with lung cancer showed again low prevalence (5%) of HPV 18 and absence of HPV 16 (31).…”

Section: %) --------------------------------------------------------mentioning

confidence: 99%

Assessment of human papillomavirus and Epstein-Barr virus in lung adenocarcinoma

Lim

2009

Oncol Rep

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Abstract. The association of human papillomavirus (HPV) and Epstein-Barr virus (EBV) infection with non-small cell lung cancer is controversial. HPV and EBV prevalence in a uniform population of lung adenocarcinoma was investigated, hypothesizing that there would be differences seen between smokers and non-smokers and between sexes. Patients involved in this study were selected from a single institution database of lung cancer. In total 497 patients with adenocarcinoma were identified and 110 patients had sufficient tissue for analysis with an in situ hybridization method that probed for high-risk and low-risk HPV and EBV. There were 65 males and 45 females, 78 patients with stage I-IIIA disease and 32 patients with stage IIIB-IV disease. There were similar number of smokers and non-smokers. Across all stages HPV and EBV staining was absent from all tissues examined. It is unlikely that HPV or EBV is an important etiological agent in adenocarcinoma of the lung, even among the neversmokers. IntroductionCigarette smoke is strongly associated with the development of lung cancer (1). While the epidemic of smoking has reduced through public health awareness programs and education, the incidence of lung cancer remains unabated. There has been a demographic change in the global pandemic with a global realignment of histological subtypes. Adenocarcinoma incidence is rising globally among both smokers and nonsmokers. Up to 30% of all diagnosed non-small cell lung cancer (NSCLC) among various Asian countries, including Singapore, do not have a history of exposure to cigarette smoking. These patients tend to be predominantly female and have adenocarcinoma (2). This has given rise to different postulates as to the possible etiologies of NSCLC in this distinct of patients, ranging from exposure to cooking oil fumes (3,4), as well as diet and cancer susceptibility genotypes among Asians (5-7). Human papillomavirus (HPV) and Epstein-Barr virus (EBV) have been variously described to be associated and causative with several cancers. HPV is likely to be causal in cervical carcinoma and head and neck squamous cell carcinoma (HNSCC), and EBV in nasopharyngeal carcinoma. There have been various reports of association between HPV and EBV with lung cancer but results have not been conclusive (8). Leveraging on the excess of non-tobacco related lung cancer in our patients we investigated HPV and EBV prevalence in a uniform population of adenocarcinoma of the lung, hypothesizing that there would be differences seen between smokers and nonsmokers and between sexes. Patients and methodsPatients. Patients involved in this study were selected from a database of NSCLC patients, diagnosed in a single institution (SGH) from 1999 to 2002. The study had the approval of the Institutional Review Board of National Cancer Centre Singapore. The main selection criterion was a diagnosis of adenocarcinoma. Four hundred and ninety-seven patients were identified and among them, 110 patients had sufficient tissue blocks available for our analysis using in ...

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Section: %) --------------------------------------------------------mentioning

confidence: 99%

Assessment of human papillomavirus and Epstein-Barr virus in lung adenocarcinoma

Lim

2009

Oncol Rep

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“…A large sample investigation reported that HPV DNA infection rate was 21.7% in 2468 lung carcinomas (11). HPV infection is considered a cocarcinogen of lung cancer and its contribution to pathogenesis has been evaluated (12)(13)(14)(15)(16)(17)(18). However, even in Asian populations, the prevalence discrepancy of HPV infection in lung cancer patients was also found with the geographic variations and tumor types.…”

Section: Introductionmentioning

confidence: 86%

Correlation of HPV-16/18 infection of human papillomavirus with lung squamous cell carcinomas in Western China

Yan

2009

Oncol Rep

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Abstract. Prevalent inconsistency of human papillomavirus (HPV) infection in lung cancer was found among recent studies from different countries with racial and geographic variations. Even in Chinese populations, the prevalent discrepancy of HPV infection in lung cancer patients was also found with the geographic variations and tumor types. To study the difference of HPV-16/18 infection in lung squamous cell carcinomas and non-cancer controls, we conducted this study to verify whether there was a similar HPV infection prevalence pattern in lung squamous cell carcinoma patients from the Western part of China. Paraffinembedded samples (180), of 72 lung squamous cell carcinomas, 37 lung adenocarcinomas and 71 non-cancer controls, were analyzed by INNO-LIPA Genotype polymerase chain reaction (PCR) and real-time PCR analysis. The data showed that 51.4% (37/72) of lung squamous cell carcinoma samples, 16.2% (6/37) of adenocarcinoma, and 22.5% (16/71) of non-cancer controls were HPV DNA positive. The risk of lung squamous cell carcinomas was 3.5 times higher among people HPV-positive (odds ratio 3.5, 95% CI 1.6-7.3, p<0.001) compared with the HPV-negative population. Adjusted by smoking status, the risk of lung squamous cell carcinomas was 3.5 times higher among people HPVpositive (odds ratio 3.5, 95% CI 1.7-7.5, p=0.001) compared with the HPV-negative population. The risk of lung squamous cell carcinomas was 16.9 times higher for patients with positive HPV-16 (odds ratio 16.9, 95% CI 3.8-75.3, p<0.0001) than negative HPV-16. Adjusted by smoking status, the risk of lung squamous cell carcinomas was 17.4 times higher among people HPV-16 positive (odds ratio 17.4, 95% CI 3.9-77.5, p<0.0001) compared with HPV-16 negative people. INNO-LIPA Genotype analysis revealed that the frequency of high risk HPV-16 and 18 genotype in lung squamous cell carcinoma cases appeared to be significant higher than that in the non-cancer controls (P<0.001), and the most frequent genotype was HPV-16 (21 cases), followed by HPV-18 (6 cases), HPV-16/18 (4 cases) in lung squamous cell carcinomas, respectively, and the majority genotype was HPV-6 (9 cases) in controls. The HPV-16 E 2 /E 6 ratio was significantly lower than the unity, suggested that the main presence of integrated form of HPV-16 genome (16/27) may contribute more to lung squamous cell carcinomas, despite its viral load estimated to be only <1 to 2 copies per cell.

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“…Although HPV 16 has been detected more frequently than HPV 18 in both squamous cell carcinomas and adenocarcinomas [111,113,115,117,133], HPV 18 predominance has been demonstrated by other researchers [118,130,134] in both squamous cell carcinomas and adenocarcinomas. The higher prevalence of HPV 33 infections in Korean lung cancer patients compared to other Asian and Western countries [115] has not been confirmed in the US and Western European countries.…”

Section: Hpv and Lung Cancermentioning

confidence: 95%

“…HPV infection has been detected in smoking and nonsmoking patients with lung squamous cell carcinoma or adenocarcinoma [112]. Although smoking has been more frequently noted in heavy smokers than in patients with a low daily cigarette consumption and non-smokers [122,127], other investigators [115] have not found any correlation between HPV and smoking status. There has been no correlation between HPV infection and gender, age, stage, grade, and lymph node status of the carcinomas [115,122,125,127].…”

Section: Hpv and Lung Cancermentioning

confidence: 99%

Vaccination against Human Papilloma Virus (HPV): Epidemiological Evidence of HPV in Non-genital Cancers

Mammas

Sourvinos

Zaravinos

et al. 2010

Pathol. Oncol. Res.

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Recently, the vaccine against human papillomavirus (HPV) was introduced in the national vaccination programmes of several countries worldwide. The established association between HPV and the progression of cervical neoplasia provides evidence of the expected protection of the vaccine against cervical cancer. During the last two decades several studies have also examined the possible involvement of HPV in non-genital cancers and have proposed the presence of HPV in oesophageal, laryngeal, oropharyngeal, lung, urothelial, breast and colon cancers. The possible involvement of HPV in these types of cancer would necessitate the introduction of the vaccine in both boys and girls. However, the role of HPV in the pathogenesis of these types of cancer has yet to be proven. Moreover, the controversial evidence of the possible impact of the vaccination against HPV in the prevention of non-genital cancers needs to be further evaluated. In this review, we present an overview of the existing epidemiological evidence regarding the detection of HPV in non-genital cancers.

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The Prevalence of Human Papillomavirus Infection in Korean Non-Small Cell Lung Cancer Patients

Cited by 34 publications

References 35 publications

Assessment of human papillomavirus and Epstein-Barr virus in lung adenocarcinoma

Assessment of human papillomavirus and Epstein-Barr virus in lung adenocarcinoma

Correlation of HPV-16/18 infection of human papillomavirus with lung squamous cell carcinomas in Western China

Vaccination against Human Papilloma Virus (HPV): Epidemiological Evidence of HPV in Non-genital Cancers

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