The prevalence of histologic atrophy and intestinal metaplasia in the corpus has decreased over 15 years in females in the Korean population

Kwon, Young Jae; Kim, Nayoung; Baek, Suji; Lee, Hye Seung; Lee, Jae-Bong; Hwang, Young Jin; Yoon, Hyuk; Shin, Cheol Min; Park, Young Soo; Kim, Jin Wook; Lee, Dong Hoon

doi:10.1111/hel.12579

Cited by 13 publications

(7 citation statements)

References 57 publications

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“…Bounder et al reported in his study 11.7% of AG and 7.4% of IM. We found that 80% of our atrophic gastritis form were related to Helicobacter Pylori infection, such findings are supported by a substantial number of studies [34,38,39]. Asaka et al reported the same prevalence (the prevalence of atrophic gastritis in H. pylori infection was 82.9%) [40].…”

Section: Discussionsupporting

confidence: 81%

Histo-epidemiological aspect of Helicobacter pylori chronic gastritis in a Moroccan population

Gui

Hechlaf²,

Ed-Day

et al. 2021

E3S Web Conf.

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Helicobacter pylori (H. Pylori) is the best example of the implication of chronical infection in carcinogenesis. The World Health Organization recognized it as a class I carcinogen since it triggers the progression of premalignant gastric lesions. The aim of this study is to define the prevalence of H. Pylori infection, related risk factors, and explore the histological features of the chronic gastritis. This is a retrospective study of 248 gastric specimens, examinated and evaluated according Sydney to system. The prevalence of H. Pylori is 67 %, chronic gastritis is observed in all the biopsies (100%). Age and gender were not a risk factors for the H. Pylori infection. Prevalence of H. Pylori was 71.93% in low socio-economic class. The severity of the chronic gastritis increases if the colonization of H. Pylori increases. In 74, 58% of cases chronic gastritis was active. Glandular atrophy presented 10.37% and in 80% was related to H. Pylori infection (p=0,004) and 12 % related to autoimmune diseases. The prevalence of Intestinal metaplasia is 10.53%, and H. Pylori was observed in 42.31% of cases (p=0.001). The dysplasia is detected in one case, in a 72 years old patient. We also observed one case of gastric adenocarcinoma, of an 80 years. Follicular gastritis are in 32% of cases, and they were more frequent in H. Pylori infected slides (82% of subjects) (p< 0.005).According to this study, H. Pylori Chronic Gastritis is very common in our population, and a coherent relationship exists between H. Pylori colonization and pre-cancerous lesions. An early eradicating should be considered as a health goal.

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Section: Discussionsupporting

confidence: 81%

Histo-epidemiological aspect of Helicobacter pylori chronic gastritis in a Moroccan population

Gui

Hechlaf²,

Ed-Day

et al. 2021

E3S Web Conf.

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“…16 The development of gastric cancer is strongly associated with a high prevalence of histological atrophy and GIM (37.7/29.6% in the antrum and 20.6/16.8% in the corpus, respectively). 17 The operative link on gastritis assessment (OLGA) and OLGIM enable the systematic evaluation of individual gastric cancer risk. 18 The proportion of high-risk OLGA and OLGIM stages has been reported to be 23.0/11.5%, 29.1/14.2%, and 41.1/30.1% at the ages of the 40s, 50s, and 60s, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…In South Korea, the age‐standardized incidence of gastric cancer in 2020 was 25.7 per 100 000 16 . The development of gastric cancer is strongly associated with a high prevalence of histological atrophy and GIM (37.7/29.6% in the antrum and 20.6/16.8% in the corpus, respectively) 17 . The operative link on gastritis assessment (OLGA) and OLGIM enable the systematic evaluation of individual gastric cancer risk 18 .…”

Section: Discussionmentioning

confidence: 99%

Carbon footprint and cost reduction by endoscopic grading of gastric intestinal metaplasia using narrow‐band imaging

Cho,

Jin,

Park

2024

J of Gastro and Hepatol

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Background and AimGastric intestinal metaplasia (GIM) is a high‐risk factor for the development of gastric cancer. Narrow‐band imaging (NBI) enables endoscopic grading of GIM (EGGIM). In the era of climate change, gastrointestinal endoscopists are expected to reduce greenhouse gas emissions and medical waste. Based on the diagnostic performance of NBI endoscopy, this study measured the environmental impact and reduced cost of implementing EGGIM during gastroscopy.MethodsUsing NBI endoscopy in 242 patients, EGGIM classification and operative link on GIM (OLGIM) staging were prospectively performed in five different areas (lesser and greater curvatures of the corpus and antrum, and the incisura angularis). We estimated the environmental impact and cost reduction of the biopsy procedures and pathological processing if EGGIM were used instead of OLGIM.ResultsThe diagnostic accuracy of NBI endoscopy for GIM was 93.0–97.1% depending on the gastric area. When a high EGGIM score ≥ 5 was the cut‐off value for predicting OLGIM stages III–IV, the area under the curve was 0.862, sensitivity was 81.9%, and specificity was 90.4%. The reduction in the carbon footprint by EGGIM was −0.4059 kg carbon dioxide equivalents per patient, equivalent to 1 mile driven by a gasoline‐powered car. The cost savings were calculated to be $47.36 per patient.ConclusionsEGGIM is a reliable method for identifying high‐risk gastric cancer patients, thereby reducing the carbon footprint and medical costs in endoscopy practice.

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“…Therefore, gastric atrophy may be regulated by molecularly distinct mechanisms to that of intestinal metaplasia (i.e., aberrant expression of CDX proteins). In other words, improvement of gastric atrophy after H. pylori eradication may be independent of changes in intestinal metaplasia [15,16,17,18,19,20], which seems to be a more sustained, stable reprogramming event of the gastric glands. In our study, the expression of CDX1 was more closely associated with changes in the intestinal metaplasia score than that of CDX2.…”

Section: Discussionmentioning

confidence: 99%

The Reduction in Gastric Atrophy after Helicobacter pylori Eradication Is Reduced by Treatment with Inhibitors of Gastric Acid Secretion

Niikura

Hayakawa

Hirata

et al. 2019

IJMS

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Background: Helicobacter pylori (H. pylori) eradication therapy may improve gastric atrophy and intestinal metaplasia, but the results of previous studies have not always been consistent. The aim of this study was to compare the histological changes of intestinal metaplasia and gastric atrophy among the use of acid-suppressing drugs after H. pylori eradication. Methods: A cohort of 242 patients who underwent successful eradication therapy for H. pylori gastritis and surveillance endoscopy examination from 1996 to 2015 was analyzed. Changes in the histological scores of intestinal metaplasia and atrophy according to drug use (proton-pump inhibitors (PPIs), H2 receptor antagonists (H2RAs), and non-acid suppressant use) were evaluated in biopsies of the antrum and corpus using a generalized linear mixed model in all patients. Results: The mean follow-up period and number of biopsies were 5.48 ± 4.69 years and 2.62 ± 1.67 times, respectively. Improvement in the atrophy scores of both the antrum (p = 0.042) and corpus (p = 0.020) were significantly superior in patients with non-acid suppressant drug use compared with those of PPI and H2RA use. Metaplasia scores in both the antrum and corpus did not improve in all groups, and no significant differences were observed among groups in the antrum (p = 0.271) and corpus (p = 0.077). Conclusions: Prolonged acid suppression by PPIs or H2RAs may limit the recovery of gastric atrophy following H. pylori eradication.

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The prevalence of histologic atrophy and intestinal metaplasia in the corpus has decreased over 15 years in females in the Korean population

Cited by 13 publications

References 57 publications

Histo-epidemiological aspect of Helicobacter pylori chronic gastritis in a Moroccan population

Histo-epidemiological aspect of Helicobacter pylori chronic gastritis in a Moroccan population

Carbon footprint and cost reduction by endoscopic grading of gastric intestinal metaplasia using narrow‐band imaging

The Reduction in Gastric Atrophy after Helicobacter pylori Eradication Is Reduced by Treatment with Inhibitors of Gastric Acid Secretion

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