The prevalence of hidradenitis suppurativa and its potential precursor lesions

Jemec, Gregor B.E.; Heidenheim, Michael; Nielsen, Niels

doi:10.1016/s0190-9622(96)90321-7

Cited by 463 publications

(451 citation statements)

References 6 publications

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“…The prevalence of HS is reported to be approximately 1%–4% of the general population, with disease onset occurring typically in young adulthood 8, 12, 13, 14. The estimates of population‐based prevalence are limited and are subject to considerable variation 11, 15.…”

Section: Introductionmentioning

confidence: 99%

A cross‐sectional epidemiological study of hidradenitis suppurativa in an Irish population (SHIP)

Delany

Gormley

Hughes

et al. 2017

Acad Dermatol Venereol

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BackgroundHidradenitis suppurativa (HS), a chronic inflammatory disease that affects apocrine gland–bearing skin, has a significant impact on patients' quality of life. Estimates of the epidemiologic prevalence of HS are highly variable, and clinical data on disease characteristics and patient burden of disease remain limited.ObjectiveThe primary objective of this study was to determine the number of patients with HS attending dermatology clinics in a hospital setting in Ireland (within a 6‐month time period). Secondary objectives included the assessment of disease characteristics and the collection of patient responses on disease burden and work productivity.MethodsThis was an epidemiologic, non‐interventional, cross‐sectional study across four dermatology clinics in Ireland over a 6‐month time period. The disease prevalence was estimated by calculating the percentage of total patients with a diagnosis of HS (the primary population) across the selected sites. Secondary analyses were performed using the full analysis set, which consisted of eligible adults (≥18 years of age) from the primary population who provided informed consent. Data from these analyses are presented as descriptive summary statistics, with the use of an analysis of covariance for continuous endpoints.ResultsThe prevalence of HS across the four selected sites was estimated at 1.4% (95% CI, 1.24–1.62). One hundred and fifty eligible patients comprised the full analysis set. The majority of participants were white (95.3%), female (70.0%), cigarette smokers (56.0%) and overweight or obese (body mass index ≥25 kg/m2, 81.8%). Most patients for whom data were available presented with Hurley stage II (50.4%), and more than a third of the full analysis set had a relative with HS (34.7%). Questionnaire responses revealed a profound impact on quality of life, including diminished work productivity and various psychological comorbidities.ConclusionThis study offers insight into the clinical features and disease burden of hidradenitis suppurativa in an Irish population.

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Section: Introductionmentioning

confidence: 99%

A cross‐sectional epidemiological study of hidradenitis suppurativa in an Irish population (SHIP)

Delany

Gormley

Hughes

et al. 2017

Acad Dermatol Venereol

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“…HS has been considered to be a rare disorder but European studies based on population samples using validated questionnaires have suggested a prevalence of 1%-2% in the general population and a peak prevalence of 4% (including mild cases) among young adults [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Hidradenitis Suppurativa in General Practice: A Pilot Study

Benhadou¹

2015

J Gen Pract

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“…A cne inversa (AI; also referred to as Hidradenitis suppurativa) is a chronic inflammatory skin disease with a prevalence rate of up to 4% (1)(2)(3)(4)(5)(6). It affects the intertriginous skin of perianal, inguinal, and axillary sites (2,5).…”

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confidence: 99%

Deficiency of IL-22 Contributes to a Chronic Inflammatory Disease: Pathogenetic Mechanisms in Acne Inversa

Wolk

Warszawska

Hoeflich

et al. 2011

The Journal of Immunology

227

283

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Overexpression of the T cell cytokine IL-22 is linked to the development of some chronic diseases, but little is known about IL-22 deficiency in humans. As demonstrated in this study, acne inversa (AI; also designated as Hidradenitis suppurativa) lesions show a relative deficiency of IL-22 and IL-20, but not of IL-17A, IL-26, IFN-γ, IL-24, or IL-1β. Moreover, AI lesions had reduced expression of membranous IL-22 and IL-20 receptors and increased expression of the natural IL-22 inhibitor, IL-22 binding protein. AI is a chronic inflammatory skin disease with prevalence up to 4% of the population and in which cutaneous bacterial persistence represents an important pathogenetic factor. Accordingly, we also found a relative deficiency of antimicrobial proteins (AMPs) in AI lesions and a positive correlation between lesional IL-22 and IL-20 versus AMP levels. IL-22, like its tissue cell downstream mediator IL-20, upregulated AMPs in reconstituted human epidermis and was critical for increased AMP levels under inflammatory conditions. The relative IL-22 deficiency in AI was not linked to lesional T cell numbers or Th22/Th1/Th17 subset markers and -inducing cytokines. However, IL-10 was highly expressed in AI lesions and correlated negatively with IL-22 expression. Moreover, IL-10 inhibited IL-22 but not IL-17 production in vitro. The IL-10 overexpression, in turn, was not associated with an elevated presence of regulatory T cells but with the enhanced presence of an IL-10–inducing cytokine. We conclude that IL-22 deficiency may contribute to the pathogenesis of certain chronic disorders as postulated in this paper for AI.

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The prevalence of hidradenitis suppurativa and its potential precursor lesions

Cited by 463 publications

References 6 publications

A cross‐sectional epidemiological study of hidradenitis suppurativa in an Irish population (SHIP)

A cross‐sectional epidemiological study of hidradenitis suppurativa in an Irish population (SHIP)

Hidradenitis Suppurativa in General Practice: A Pilot Study

Deficiency of IL-22 Contributes to a Chronic Inflammatory Disease: Pathogenetic Mechanisms in Acne Inversa

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