The prevalence of hereditary angioedema in a Chinese cohort with decreased complement 4 levels

Cui, Qi; Xu, Qingxiu; Yang, Yaqi; Li, Wenjing; Huang, Nan; Chen, Hao; Ma, Dongxia; Zhang, Shuchen; Yang, Lin; Zhu, Rongfei

doi:10.1016/j.waojou.2021.100620

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…The prevalence of HAE in Black patients (1.64 cases per 100,000) was almost similar to that of White patients (1.47 cases per 100,000), whereas it was lower among Hispanic patients (0.80 cases per 100,000) [ 47 ]. Furthermore, according to a study conducted in Tongji Hospital in China, the prevalence of HAE was reported to be 2.43 cases per 10,000 in patients with decreased complement 4 level [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

Epidemiology, economic, and humanistic burden of hereditary angioedema: a systematic review

Guan,

Sheng,

Liu

et al. 2024

Orphanet J Rare Dis

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Background This systematic study aims to assess the global epidemiologic, economic, and humanistic burden of illness associated with all types of hereditary angioedema. Methods A systematic search for articles reporting the epidemiologic, economic, and humanistic burden associated with patients with HAE was conducted using English and Chinese literature databases from the inception to May 23, 2022. The selected studies were assessed for their quality and risk of bias. The study was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses and registered with the International Prospective Register of Systematic Reviews (PROSPERO; CRD42022352377). Results In total, 65 articles that met the search inclusion criteria reported 10,310 patients with HAE, of whom 5861 were female patients. Altogether, 4312 patients (81%) and 479 patients (9%) had type 1 and type 2 HAE, respectively, whereas 422 patients (8%) had HAE-normal C1-INH. The overall prevalence of all types of HAE was between 0.13 and 1.6 cases per 100,000. The mean or median delay from the first onset of a symptom of HAE to confirmed diagnosis ranged from 3.9 to 26 years. The estimated risk of death from asphyxiation was 8.6% for patients with HAE. Hospitalization, medication, unnecessary surgeries, doctor visits, specialist services, and nursing costs are direct expenses that contribute to the growing economic burden. The indirect cost accounted mostly due to missing work ($3402/year) and loss of productivity ($5750/year). Furthermore, impairment of QoL as reported by patient-reported outcomes was observed. QoL measures identified depression, anxiety, and stress to be the most common symptoms for adult patients and children. Conclusion This study highlights the importance of early diagnosis and the need for improving awareness among health care professionals to reduce the burden of HAE on patients and society.

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Section: Resultsmentioning

confidence: 99%