The Prevalence of Hepatitis C Virus Infection in Patients With Thalassemia in Zabol City of Iran

Yousefi, Maysam; Dehesh, Mohammad Moein; Ebadi, Mehrnoosh; Dehghan, Azizallah

doi:10.17795/iji-37009

Cited by 5 publications

(4 citation statements)

References 7 publications

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“…However, the HCV seroprevalence was high even in thalassemia patients born after 1996 with 5.1% in patients aged 11 -20 and 1.9% in patients aged < 11, which can be because of nosocomial transmission (12). Another two studies from Zabol city showed 8.5% and 10% HCV seroprevalence, which is consistent with 8.7% HCV seroprevalence among participants of the present study from Zabol city (13,14). In the current study, HCV RNA was detected in 53% of the HCV-seropositive IDH patients with available data for the assessment of HCV RNA.…”

Section: Discussionsupporting

confidence: 89%

Hepatitis B and Hepatitis C in Patients with Inherited Disorders of Hemoglobin in Sistan and Baluchistan Province, Iran

Khosravi

Sharafi

Moghadam

et al. 2018

Arch Clin Infect Dis

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Background: The hepatitis C virus (HCV) and hepatitis B virus (HBV) infections are significant concerns in patients with inherited disorders of hemoglobin (IDH). Objectives: This study aimed to assess the prevalence of HCV and HBV infections in a large cohort of patients with IDH in Sistan and Baluchistan province, Iran. Methods: In this retrospective study, 2391 patients with IDH in Sistan and Baluchistan were enrolled. The anti-HCV antibody (HCV Ab) and hepatitis B surface antigen (HBsAg) were assessed using ELISA. Results: A total of 2387 patients with a mean age of 12.7 years were included in the final analysis. Most of the patients were residents of Zahedan city (28.1%) and suffered beta-thalassemia major (99.2%). The prevalence of HCV Ab was 5.87% (95% CI = 5.0%-6.89%) and HBsAg was detected in 0.29% (95%CI = 0.14%-0.6%) of the patients. The prevalence of HCV Ab was associated with the age of patients, and there was a great difference in the prevalence of HCV Ab between patients with IDH who born before and after 1996 (17.2% vs. 5.1%; P < 0.05). Among 101 patients with positive results for HCV Ab who were tested for HCV RNA, 53 (52.5%; 95% CI = 42.8%-61.9%) had HCV RNA in their serum samples. Moreover, 40 patients had results for HCV genotyping including 29 (72.5%) HCV genotype 3 and 11 (27.5%) HCV genotype 1. Conclusions: Hepatitis C had a high seroprevalence of 5.87% in patients with IDH in Sistan and Baluchistan while hepatitis B had a low seroprevalence of 0.29% that is unusual in a region with > 3% prevalence of hepatitis B in the general population.

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Section: Discussionsupporting

confidence: 89%

Hepatitis B and Hepatitis C in Patients with Inherited Disorders of Hemoglobin in Sistan and Baluchistan Province, Iran

Khosravi

Sharafi

Moghadam

et al. 2018

Arch Clin Infect Dis

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“…There is also a significant relationship between HCV positive with the number of blood units and the duration of blood transfusion [ 23 ], which is consistent with the present study. In a 2017 study in Zabul, among 152 thalassemia patients, 13 (8.5%) were infected with HCV [ 24 ]. In another study conducted in Bandar Abbas in 2018, 17 % of patients with thalassemia major were infected with HCV [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of HBV and HCV infection in beta-thalassemia major patients of Tabriz city, Iran

Mirzaei

Shamsasenjan

Jafari

et al. 2021

New Microbes and New Infections

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People with beta-thalassemia major are more likely to acquire blood-borne viral infections due to the need for frequent blood transfusions. Of these viruses, hepatitis B virus (HBV) and hepatitis C virus (HCV) are of particular importance. In this study, the prevalence of HBV, HCV and their risk factors in beta-thalassemia major patients in East Azerbaijan province was investigated. The study was descriptive cross-sectional, and 116 beta-thalassemia major patients who received blood in Shahid Ghazi hospital and Children’s hospital in Tabriz city were studied. Data were collected by a questionnaire, and blood samples of patients in terms of serum markers HCV-Ab, HBsAg and HBs-Ab were analyzed by ELISA, and positive HCV-Ab results were confirmed by Real Time-PCR. Then using SPSS software version 22 and with the help of t-tests including Anova T-test, Man-Whitney U test, Independent sample t-test, chi-square and Fisher exact test, Statistical studies were performed. Of the 116 patients studied, no HBsAg positive cases were found. Four patients (3.4%) were positive for HCV-Ab, of which two patients (1.7%) became HCV-RNA positive after Real Time-PCR. There was a significant relationship between HCV-Ab positive and HCV-RNA positive (P = 0.000), blood transfusion intervals (P = 0.043), number of injected blood units (P = 0.001) and duration of blood transfusion (P = 0.006). The prevalence of HCV was lower in patients who started receiving blood after a blood donor screening program. HCV is less prevalent in thalassemia patients in East Azerbaijan province than in some studies in the country and various global statistics. After 1996, the prevalence of HCV in the thalassemia patient population has decreased significantly, and it seems that HCV infections since 1996 have been associated with various factors such as people’s jobs, position, behaviour in society, etc.

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“…We read with interest the recently published article by Yousefi et al (1) in your journal. Control of Hepatitis C virus (HCV) infection has been amongst our priorities in Iran and most individuals are evaluated for HCV infection and treated as well (2,3).…”

Section: Dear Editormentioning

confidence: 99%

Burden of Hepatitis C on Patients with Thalassemia

Sepehri

Alavian

2016

Int J Infect

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We read with interest the recently published article by Yousefi et al. (1) in your journal. Control of Hepatitis C virus (HCV) infection has been amongst our priorities in Iran and most individuals are evaluated for HCV infection and treated as well (2, 3). However, we found some points that need further clarification. First of all, the authors claimed that 13 (8.5%) of 152 patients with thalassemia were anti-HCV antibody positive, however we would like to mention that antibody positivity is not correlated with infectivity, and confirmation with HCV RNA molecular study is necessary for this conclusion. History of therapy with antiviral drugs was missing in the study while there should be approximately 50% response to pegylated-base and ribavirin therapy, according to our experience (4). They mentioned that 65 patients with thalassemia and hemophilia received blood transfusion before 1995 and 87 patients after this time. The rate of HCV infection before 1995 was significantly higher than the following years. We think that the word "hemophilia" was a kind of typing error. We agree strongly with the authors about the decreasing burden of HCV infection after 1995, time of blood screening for HCV infection in Iran.

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The Prevalence of Hepatitis C Virus Infection in Patients With Thalassemia in Zabol City of Iran

Cited by 5 publications

References 7 publications

Hepatitis B and Hepatitis C in Patients with Inherited Disorders of Hemoglobin in Sistan and Baluchistan Province, Iran

Hepatitis B and Hepatitis C in Patients with Inherited Disorders of Hemoglobin in Sistan and Baluchistan Province, Iran

Prevalence of HBV and HCV infection in beta-thalassemia major patients of Tabriz city, Iran

Burden of Hepatitis C on Patients with Thalassemia

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