The Prevalence of Hepatitis C Virus Infection in the United States, 1999 through 2002

Abstract

Many Americans are infected with HCV. Most were born between 1945 and 1964 and can be identified with current screening criteria. History of injection drug use is the strongest risk factor for infection.

Study of changes in lipid profile and insulin resistance in Egyptian patients with chronic hepatitis C genotype 4 in the era of DAAs

“…Hepatitis C virus (HCV) represents the major causative agent of chronic liver disease affecting more than 170 million patients worldwide [1]. Chronic hepatitis C (CHC) could be considered a special type of metabolic disease involving insulin resistance (IR), hepatic steatosis, and modulation of lipid-cholesterol biosynthesis that may lead to fatty liver, hypo-betalipoproteinemia, hypercholesterolemia, and increased risk for ischemic heart diseases (IHD) [2,3].…”

Regional and global summary estimates of antibody to hepatitis C virus prevalence in detainee populations: Seeing the forest and the trees?

“…1,2 Using systematic review and mathematical modeling, Hanifiah et al recently estimated that the global prevalence of antibody to HCV (anti-HCV) increased from 2.3% (95% uncertainty interval [UI]: 2.1%-2.5%) to 2.8% (95% UI: 2.6%-3.1%) from 1990 to 2005, for an increase in the number of anti-HCV-positive persons from 122 to 184 million. 3 Although this estimate is higher than some previously published studies, the researchers rightly suggest that their estimate may nonetheless be "conservative" or may underestimate the global prevalence of anti-HCV.…”

“…Based on 1999-2002 NHANES data, the estimated anti-HCV prevalence was 1.6% (range, 1.3%-1.9%) among noninstitutionalized persons in the United States. 1 In 12 selected studies of anti-HCV prevalence in U.S. detainee populations conducted from 1985 to 2002, anti-HCV prevalence estimates ranged from 23.1% to 41%. 5 Notably, from these same studies, anti-HCV prevalence estimates among U.S. detainees with a history of injection drug use were exceptionally high, ranging from 32.3% to 82.8%.…”

An intervention to prevent symptoms associated with hepatitis C: a pilot study

“…Progressive home walking was chosen as the intervention because it is an easy-to-do activity and because moderate activity has been seen as effective in the amelioration of symptoms and side effects in similar chronic illness populations. Armstrong et al (2006) estimated that approximately 3.2 million U.S. citizens have evidence of chronic HCV infection. Although persons with HCV may not present with signs or symptoms for as long as 20 years, they experience much higher levels of morbidity and mortality as the disease progresses.…”