The Prevalence of Hepatitis B Virus in Patients With Hepatocellular Carcinoma in Gombe, North Eastern Nigeria

Mustapha, Sagir; Pindiga, UH

doi:10.4314/smj2.v6i4.12848

Cited by 5 publications

(15 citation statements)

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“…In agreement with other studies [11,12,17,18,24], the peak age of incidence of hepatocellular carcinoma in our study was found to be in the fourth decade of life, which is about a decade or two earlier compared to the findings in developed countries. The occurrence of HCC in a younger age group compared to the Western population suggests an early exposure to carcinogenic factors in our patients.…”

Section: Discussionsupporting

confidence: 93%

“…The mean duration from onset of symptoms to time of death was 16 weeks, which is in agreement with the findings from other studies [11,12,38]. Hepatic failure and intraperitoneal hemorrhage were the most common causes of death.…”

Section: Discussionsupporting

confidence: 91%

“…However, the outcome of treatment of HCC in our environment has been poor because the majority of these patients present late to the hospital with an advanced stage of the disease and only palliative care is possible [11,12]. This is partly due to a lack of community awareness on the importance of early reporting to hospital for the early diagnosis and treatment of this condition.…”

Section: Introductionmentioning

confidence: 99%

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Hepatocellular carcinoma: clinicopathological profile and challenges of management in a resource-limited setting

et al. 2014

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BackgroundHepatocellular carcinoma is one of the most common cancers worldwide and its incidence is reported to be increasing in resource-limited countries. There is a paucity of published data regarding hepatocellular carcinoma in Tanzania, and the study area in particular. This study describes the clinicopathological profile of hepatocellular carcinoma in our local setting and highlights the challenging problems in the management of this disease.MethodsThis was a retrospective study of histopathologically confirmed cases of hepatocellular carcinoma seen at Bugando Medical Center between March 2009 and February 2013.ResultsA total of 142 patients (M: F = 2.2: 1) were studied representing 4.6% of all malignancies. The median age of patients was 45 years. Hepatitis B virus infection (66.2%) and heavy alcohol consumption (60.6%) were the most frequently identified risk factors for hepatocellular carcinoma. The majority of patients (88.0%) presented late with advanced stages. HBsAg was positive in 66.2% of the patients and Hepatitis C Virus antibody in 16.9%. Thirteen (9.2%) patients tested positive for HIV infection. Most patients (52.8%) had both right and left lobe involvement. The trabecular pattern (47.9%) was the most frequent histopathological type. None of patients had curative therapy because of the advanced nature of the disease. Coagulopathy (45.7%) was the most common complications. The overall mortality rate was 46.5% and it was significantly associated with comorbidity, HIV positivity, CD4+ count <200 cells/μl, high histological grade, advanced stage of the tumor, presence of distant metastases at the time of diagnosis, and associated complications (P < 0.001). The overall median duration of hospital stay was 14 days. The majority of patients (71.1%) were lost to follow-up at the end of the follow-up period.ConclusionsHepatocellular carcinoma patients in this region are relatively young at diagnosis and the majority of them present late with an advanced stage and high rate of distant metastasis. Lack of awareness of the disease, poor accessibility to healthcare facilities, and lack of screening programs in this region may contribute to advanced disease at the time of diagnosis. There is a need for early detection, adequate treatment, and proper follow-up to improve treatment outcome.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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Hepatocellular carcinoma: clinicopathological profile and challenges of management in a resource-limited setting

et al. 2014

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“…[9] This also points to the leading role of HBV in the causation of liver disease in Nigeria. [9,10] In this study, the importance and indispensability of using special stains in liver biopsy interpretation were highlighted in the number of biopsies that were positive for iron pigment, copper-associated proteins, and for HBsAg viral inclusions which are not visible on routine H and E examinations.…”

Section: Discussionmentioning

confidence: 92%

The use of special stains in liver biopsy interpretation: Implications for the management of liver disease in Nigeria

2016

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“…In Nigeria, HBV infection has been studied in several populations (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21) (Table). Despite the availability of a safe and effective vaccine since 1982 (22,23) and its inclusion in Nigeria's national immunization program in 1995, the vaccine only became available to the public in 2004 (24,25).…”

Section: Introduction and Epidemiologymentioning

confidence: 99%

Chronic Hepatitis B: Management Challenges in Resource-Poor Coun-tries

Nwokediuko¹

2011

Hepat Mon

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The Prevalence of Hepatitis B Virus in Patients With Hepatocellular Carcinoma in Gombe, North Eastern Nigeria

Cited by 5 publications

References 0 publications

Hepatocellular carcinoma: clinicopathological profile and challenges of management in a resource-limited setting

Hepatocellular carcinoma: clinicopathological profile and challenges of management in a resource-limited setting

The use of special stains in liver biopsy interpretation: Implications for the management of liver disease in Nigeria

Chronic Hepatitis B: Management Challenges in Resource-Poor Coun-tries

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