The prevalence of gastrointestinal symptoms in patients with chronic renal failure is increased and associated with impaired psychological general well-being

Strid, Hans; Simrén, Magnus; Johansson, Alf; Svedlund, Jan; Samuelsson, Ola; Bjõrnsson, Einar

doi:10.1093/ndt/17.8.1434

Cited by 117 publications

(144 citation statements)

References 15 publications

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“…Subjects respond using a 7-point Likert scale defined by verbal denominators ranging from no symptoms (score of 1) to very severe symptoms (score of 7). The GSRS has been validated and used widely in studies of gastrointestinal symptoms in patients with GERD [23][24][25] , and norm values for the general population are available [26,27] . The GSRS has also been used to assess the impact of treatment in patients with dyspepsia [28,29] , and a full validation of the GSRS in patients with dyspepsia has been performed [70] .…”

Section: Gastrointestinal Symptom Rating Scalementioning

confidence: 99%

An International Comparison of the Burden of Illness in Patients with Dyspepsia

Halling

Kulich

Carlsson

et al. 2008

Dig Dis

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Background/Aims: This study investigates the symptoms and the impact of symptoms on health-related quality of life (HRQL) in patients consulting with dyspepsia. Methods: Consecutive patients with a diagnosis of dyspepsia were recruited from primary and secondary care in Germany, Hungary, Italy, Poland, South Africa and Spain. Investigators assessed symptom frequency and severity, and subjects completed the following questionnaires: the Gastrointestinal Symptom Rating Scale (GSRS), the Quality of Life in Reflux and Dyspepsia (QOLRAD) questionnaire, the Hospital Anxiety and Depression (HAD) scale and the Short Form 36 (SF-36). Results: 853 dyspepsia patients were included. Mean GSRS scores showed that patients were most troubled by abdominal pain and indigestion. QOLRAD scores indicated that symptoms caused emotional distress, food/drink problems and reduced vitality, with a lesser effect on sleep and physical functioning. Mean SF-36 scores were lower than mean normative values for all domains, indicating that patients had a worse HRQL than the normal population, particularly for Bodily Pain, Role Physical and Role Emotional. Of patients in each country, 18–43% were anxious and 11–21% were depressed. Conclusions: Patients with dyspepsia have reduced HRQL because their symptoms – particularly abdominal pain and indigestion – cause emotional distress, problems with food and drink, and impaired vitality.

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Section: Gastrointestinal Symptom Rating Scalementioning

confidence: 99%

An International Comparison of the Burden of Illness in Patients with Dyspepsia

Halling

Kulich

Carlsson

et al. 2008

Dig Dis

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“…Another recent study using a similar approach found that IBS is associated with impairment of the QOL relative to patients with GERD, asthma and migraine, but that patients with IBS seem to have better QOL than patients with panic disorder and rheumatoid arthritis [43]. Using the PGWB index, the psychological general well-being in patients with IBS is comparable to patients with end-stage renal disease, but better than normal values from the population and patients with inflammatory bowel disease in remission [37, 44, 45, 46](fig. 1).…”

Section: Qol Studies In Ibsmentioning

confidence: 99%

Quality of Life and Illness Costs in Irritable Bowel Syndrome

et al. 2004

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Quality of life is reduced in patients with irritable bowel syndrome, and the costs for this disease are substantial to society. During a meeting in London, UK, the IBiS club reviewed the literature on these subjects. Drawbacks and advantages with existing instruments to assess quality of life and costs were discussed and the clinical and scientific relevance of the current knowledge was assessed. A summary from the meeting is presented in this paper.

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“…Approximately 76% of HD patients exhibit such symptoms (14). Strid et al in an observational study showed that pain, indigestion, constipation, diarrhea and eating dysfunction were significantly worse in CKD patients than the general population (15). GI symptoms may result in malnutrition and can cause impaired well-being in these patients.…”

Section: Discussionmentioning

confidence: 99%

Synbiotic supplementation promotes improvement of chronic diarrhea of unknown etiology in patient with chronic kidney disease and provides better outcomes in dialysis

et al. 2016

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Enfermedad renal crónica. Microbiota. Simbióticos. Diarrea. Hemodiálisis. Key words:Chronic kidney disease. Microbiota. Synbiotics. Diarrhea. Hemodialysis. ResumenIntroducción: los pacientes con enfermedad renal crónica (ERC) a menudo tienen síntomas gastrointestinales que pueden provocar desnutrición y un impacto negativo en su calidad de vida. La modulación de la microbiota intestinal puede ser una estrategia para promover la salud del huésped y la homeostasis. Caso clínico: los autores presentan un caso de diarrea crónica de etiología desconocida en un paciente en hemodiálisis (HD). Después de varias intervenciones fallidas durante un año, se realizó el tratamiento simbiótico. Los episodios de diarrea cesaron después de tres meses de la suplementación diaria y ambos parámetros bioquímicos y nutricionales mejoraron. La terapia con simbióticos promovió beneficios clínicos para este paciente. Discusión: por lo tanto, esta sencilla terapia puede ser una alternativa prometedora en la ERC y debe ser probada en estudios más amplios.Synbiotic supplementation promotes improvement of chronic diarrhea of unknown etiology in patient with chronic kidney disease and provides better outcomes in dialysis AbstractBackground: Chronic kidney disease (CKD) patients often have gastrointestinal symptoms which may result in malnutrition and a negative impact on their quality of life. Modulation of the gut microbiota can be a strategy to promote host health and homeostasis. Case report: The authors present a case of chronic diarrhea in a hemodialysis (HD) patient with an unknown etiology. After about one year and several failed interventions, synbiotic therapy was performed. The diarrhea episodes ceased after three months of daily supplementation and both biochemical and nutritional parameters improved. Synbyotic therapy promoted clinical benefits in this patient. Discussion: Therefore, this simple therapy may be a promising alternative in CKD and it should be tested in larger studies.

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The prevalence of gastrointestinal symptoms in patients with chronic renal failure is increased and associated with impaired psychological general well-being

Abstract: The prevalence of GI symptoms is high in patients with CRF and is associated with impairment in psychological general well-being. Presence of dialysis or not, type of dialysis, and presence or absence of diabetes mellitus seem to have limited impact on GI symptoms.

Cited by 117 publications

References 15 publications

An International Comparison of the Burden of Illness in Patients with Dyspepsia

An International Comparison of the Burden of Illness in Patients with Dyspepsia

Quality of Life and Illness Costs in Irritable Bowel Syndrome

Synbiotic supplementation promotes improvement of chronic diarrhea of unknown etiology in patient with chronic kidney disease and provides better outcomes in dialysis

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