The Prevalence of Erectile Dysfunction in the Primary Care Setting

Grover, Steven A.; Lowensteyn, Ilka; Kaouache, Mohammed; Marchand, Sylvie; Coupal, Louis; DeCarolis, Emidio; Zoccoli, Joseph; Defoy, Isabelle

doi:10.1001/archinte.166.2.213

Cited by 226 publications

(57 citation statements)

References 35 publications

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“…This association between erectile dysfunction and cardiovascular risk is complex as erectile dysfunction commonly coexists with conditions that are associated with increased risk of cardiovascular disease, namely obesity, metabolic syndrome and Type II diabetes, which are also associated with lower testosterone levels. 80,81,97,99 Thus, lower testosterone levels are associated with higher body mass index (BMI), and with increased prevalence and incidence of metabolic syndrome and Type II diabetes in middle-aged and older men. 10,11,13,14,19,[100][101][102][103][104][105][106][107] In addition, lower testosterone levels are associated with surrogate markers for cardiovascular disease, including less favorable carotid intima medial thickness, 108-110 ankle/brachial index as a measure of peripheral arterial disease 111 and calcific aortic atheroma.…”

Section: Testosterone Cardiovascular Risk and Mortality In Aging Menmentioning

confidence: 99%

Are declining testosterone levels a major risk factor for ill-health in aging men?

Yeap

2008

Int J Impot Res

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As men grow older, testosterone levels fall, with a steeper decline in unbound or free testosterone compared with total testosterone concentrations. Lower testosterone levels have been associated with poorer cognitive function, and with impaired general and sexual health in aging men. Recently, lower testosterone levels have been linked with metabolic syndrome and type II diabetes, both conditions associated with cardiovascular disease, and shown to predict higher overall and cardiovascular-related mortality in middle-aged and older men. However, reverse causation has to be considered, as systemic illness may result in reduced testosterone levels. Thus, the strength of these associations and the likely direction of causation need to be carefully considered. Furthermore, these conditions may overlap, for example aging, lower testosterone levels, erectile dysfunction and cardiovascular disease are interrelated. Cross-sectional and longitudinal observational studies may be informative. However, ultimately randomized controlled trials of testosterone therapy are needed to clarify its role in the maintenance of general and sexual health in aging men. Testosterone therapy should be considered in hypogonadal men who meet rigorous criteria for the diagnosis of androgen deficiency. Additional consideration should be given to designing and testing interventions that may prevent or ameliorate the age-related decline in testosterone levels in men.

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Section: Testosterone Cardiovascular Risk and Mortality In Aging Menmentioning

confidence: 99%

Are declining testosterone levels a major risk factor for ill-health in aging men?

Yeap

2008

Int J Impot Res

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“…4,5 A prevalence of 35% ED was found in a study as early as 1980 in patients with diabetes mellitus. 1 The prevalence of ED was found to be 49% in men aged 40-88 years in a Canadian study, 6 while severe ED was found in 30% of men in a large study in Israel. 7 A prevalence of ED of as high as 71% was also demonstrated in another study in France.…”

Section: Introductionmentioning

confidence: 97%

“…9 Multiple modifiable risk factors were found to be independently associated with ED in several trials, including diabetes mellitus, obesity, current smoking and hypertension. 5,6 The prevalence of ED increased progressively with age. Other important associations were treatment with insulin or oral hypoglycaemic agents, retinopathy, and symptomatic autonomic and peripheral neuropathy.…”

Section: Introductionmentioning

confidence: 99%

“…1 Men with ED are also more likely to have hypertension and diabetes mellitus, or to have undiagnosed hyperglycaemia. 6,10 ED severity seems to increase with age, diabetes mellitus duration, poor glycaemic control, the presence of microvascular complications, diuretic therapy and cardiovascular disease. 7 The consumption of small amounts of alcohol and physical activity might be protective.…”

Section: Introductionmentioning

confidence: 99%

“…There seems to be a strong link between ED and atherosclerotic vascular disease. 6,10,17,18 Endothelial dysfunction is the common underlying factor linking ED with cardiovascular disease. [19][20][21] This plays an important role in the development of atherosclerosis and systemic vascular diseases, such as diabetes mellitus, hypertension, dyslipidaemia, ischaemic heart disease, strokes and claudication.…”

Section: Introductionmentioning

confidence: 99%

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The prevalence and associations of erectile dysfunction in a South African male diabetic urban population

Kemp

Rheeder

2015

Journal of Endocrinology, Metabolism and Diabetes of South Afri

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Background: Erectile dysfunction (ED) is a common condition in patients with type 1 or type 2 diabetes mellitus. The prevalence and predictors in our patient population are unknown since minimal data exist for this condition in South Africa. Method: An observational, cross-sectional study was performed on 150 consecutive male patients aged ≥ 50 years, with either type 1 or type 2 diabetes mellitus, attending the Steve Biko Academic Hospital Diabetes Clinic. These patients were evaluated for diabetes mellitus control and medical complications, and for the presence of ED. Morning serum testosterone levels were determined. Results: Some degree of ED was reported in 95% of the patients, with 51% reporting serious dysfunction. Using multivariate logistic regression, it was determined that the significant factors associated with ED were age, body mass index, the peripheral neuropathy score and diuretic therapy. Differences in quality-of-life scores were seen in some ED subgroups. Conclusion: This study confirms the high prevalence of ED in diabetic male patients in a tertiary setting. It is suggested that universal screening should be performed for this population group. Multiple predictors of ED were identified in this study. ED negatively affected quality of life, but not in a statistically significant way.

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Erectile Dysfunction and Thyroid Disorders

Mascitelli¹,

Pezzetta²

2006

Arch Intern Med

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The Prevalence of Erectile Dysfunction in the Primary Care Setting

Abstract: Cardiovascular disease, diabetes, future coronary risk, and increasing fasting glucose levels are independently associated with ED. It remains to be determined if ED precedes the development of these conditions.

Cited by 226 publications

References 35 publications

Are declining testosterone levels a major risk factor for ill-health in aging men?

Are declining testosterone levels a major risk factor for ill-health in aging men?

The prevalence and associations of erectile dysfunction in a South African male diabetic urban population

Erectile Dysfunction and Thyroid Disorders

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