The Prevalence of Dyslipidemia and Other Cardiovascular Risk Factors in Youth with Diabetes

Hamilton, Luke; Wilson, Don P.; O'Reilly, Crystal M; González, José; Torre, Alejandro de la

doi:10.2174/1573396314666180221163924

Cited by 3 publications

(2 citation statements)

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“…Insulin resistance is known to be associated with an adverse cardiometabolic risk factor profile, and both obesity and insulin resistance appear to contribute independently to CV risk in representative populations of youth . In our obese dysglycemic adult and youth cohorts, the dominant associations with CV risk factors were from insulin sensitivity without a separate effect of obesity.…”

Section: Discussionmentioning

confidence: 70%

Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults

Edelstein

2019

Pediatr Diabetes

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Background Obesity and pubertal insulin resistance worsen cardiovascular (CV) risk factors in youth. It is unclear how the relationships of obesity and insulin resistance with CV risk compare to adults. Subjects and Methods We evaluated 66 pubertal youth (mean ± SD: age 14.2 ± 2.0 years, body mass index [BMI] 36.6 ± 6.0 kg/m2, hemoglobin A1c [HbA1c] 38.5 ± 6.1 mmol/mol) and 355 adults with comparable BMI (age 52.7 ± 9.4 years, BMI 35.1 ± 5.1 kg/m2, HbA1c 39.8 ± 4.2 mmol/mol) participating in a multicenter study. Insulin sensitivity was quantified using hyperglycemic clamps. Assessment of CV risk factors was standardized across sites. Regression analyses compared the impact of insulin sensitivity and CV risk factors between youth and adults. Results Obese pubertal youth were more insulin resistant than comparably obese adults (P < .001), but with similar slopes for the inverse relationship between insulin sensitivity and obesity. The impact of obesity on CV risk factors was explained by insulin sensitivity (P = NS after adjustment for sensitivity). The two age groups did not differ in relationships between insulin sensitivity and diastolic blood pressure, total cholesterol, and low‐density lipoprotein (LDL) cholesterol, after adjusting for obesity. However, while systolic blood pressure (SBP) and high‐density lipoprotein (HDL) cholesterol exhibited the expected direct and inverse relationships, respectively with insulin sensitivity in adults, these slopes were flat in youth across the range of insulin sensitivity (P ≤ .05 for group differences). Conclusions Effects of obesity on CV risk factors were attributable to insulin sensitivity in both groups. The relationships between insulin sensitivity and CV risk factors were similar in obese youth and adult groups except for SBP and HDL cholesterol. Clinical Trial Registration: The RISE consortium studies are registered through http://clinicaltrials.gov as NCT01779362 (Adult Medication Study); NCT01763346 (Adult Surgery Study); and NCT01779375 (Pediatric Medication Study). Clinical trial registration numbers: NCT01779362, NCT01779375 and NCT01763346 at http://clinicaltrials.gov

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Section: Discussionmentioning

confidence: 70%

Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults

Edelstein

2019

Pediatr Diabetes

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“…Dyslipidemia is a common disease that can lead to atherosclerosis and increase the risk of coronary heart disease and ischemic stroke [4]. Studies have shown that the incidence of abnormal lipid metabolism is increasing each year, and lipid metabolism disorder can increase the risk of cardiovascular disease and the incidence of related diseases [5]. Current studies have shown that there is a dose-response relationship between urinary metal levels and coronary heart disease [6,7].…”

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confidence: 99%

Association of Urine Lead Exposure with Lipid Metabolism Risk Factors and Diseases in Xinxiang, China

Dong¹,

Wang²,

Jiang³

et al. 2020

Pol. J. Environ. Stud.

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With social and economic improvements often comes an increase in environmental pollution, which is becoming more worrisome and can have many adverse effects on the lives of local residents through atmosphere, soil and water exposure [1]. Therefore, increasing attention is being paid toward environmental pollution problems, including heavy metal pollution. Heavy metals such as lead are serious environmental pollutants and their impact on human health should

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Increased aortic stiffness index in patients with type 1 diabetes without cardiovascular disease compared to controls

Zoppini

Bergamini

Trombetta

et al. 2019

J Endocrinol Invest

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The Prevalence of Dyslipidemia and Other Cardiovascular Risk Factors in Youth with Diabetes

Abstract: CVD risk factors are common in children with diabetes mellitus. Good glycemic control, early identification, and effective life-long management of all CVD risk factors may help decrease the high rate of premature morbidity and mortality in diabetes.

Cited by 3 publications

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Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults

Obesity and insulin sensitivity effects on cardiovascular risk factors: Comparisons of obese dysglycemic youth and adults

Association of Urine Lead Exposure with Lipid Metabolism Risk Factors and Diseases in Xinxiang, China

Increased aortic stiffness index in patients with type 1 diabetes without cardiovascular disease compared to controls

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