“…Epidemiological evidence suggests that substance dependence is significantly more common among American Indian and Alaska Natives (AI/ANs, the indigenous peoples of the continental United States) than among other ethnic populations within the United States (Beals et al, 2003b;Beauvais, 1996;King et al, 1992;Kunitz et al, 1999;Kunitz and Levy, 1994;May, 1995May, , 1996Robin et al, 1998;Spicer et al, 2003;Whitesell et al, 2006). Our own work in American Indian (AI) communities has demonstrated significant disparities in rates of dependence, not only between AIs and the United Statespopulation as a whole, but between AI tribal communities as well (Beals et al, 2005a;Beals et al, 2005b;Beals et al, 2003b;O'Connell et al, 2005;Spicer et al, 2003;Whitesell et al, 2006;Whitesell et al, in press).…”