The prevalence of diffuse idiopathic skeletal hyperostosis in patients with diabetes mellitus

Sencan, D.; Elden, Hasan; Nacitarhan, Vedat; Şencan, Mehmet; Kaptanoğlu, Erkan

doi:10.1007/s00296-004-0474-9

Cited by 85 publications

(48 citation statements)

References 15 publications

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“…For instance, no differences in the prevalence of DM between 50 patients with DISH and a control group of 50 persons without DISH were found (Daragon et al 1995). In a study of 133 patients with DM and a control group of 133 persons, no statistically significant difference in the prevalence of DISH was found between the two groups (Sencan et al 2005). Vezyroglou et al (1996) found that DM alone was not a risk factor, but in combination with high levels of uric acid and/or hyperlipemia patients had a significantly higher incidence of DISH (Vezyroglou et al 1996).…”

Section: Treatmentmentioning

confidence: 99%

“…DISH is often linked to obesity (Forestier & Rotes-Querol 1950;Resnick & Niwayama 1976;Utsinger 1985;Denko et al 1994;Vezyroglou et al 1996;Mata et al 1997;el Miedany et al 2000;Belanger & Rowe 2001;Kiss et al 2002a;Mader et al 2005). In a case control study of 131 patients, the body mass index (BMI) was significantly higher in the DISH group than in the control group (Sencan et al 2005). Clinical consequences of obesity can be hypertension, OA, pulmonary and cardiac failure, type 2 diabetes mellitus (DM) and cardiovascular diseases.…”

Section: Treatmentmentioning

confidence: 99%

“…Although much is still unknown about the etiologic factors involved in human DISH, obesity and type 2 DM are often linked to the occurrence of DISH (Belanger & Rowe 2001;Kiss et al 2002a;Li et al 2007). Since some studies question this link (Daragon et al 1995;Sencan et al 2005), more research on the involvement of high levels of insulin in the occurrence of DISH are needed. In dogs, obese or not, DM is most often the result of autoimmune mechanisms affecting the b-cell function and therefore more comparable to the human type 1 DM, in which there is a insulin deficiency instead of an insulin resistance as in type 2 DM (Rijnberk et al 2003;Catchpole et al 2008).…”

Section: Treatmentmentioning

confidence: 99%

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Spinal hyperostosis in humans and companion animals

Kranenburg

Hazewinkel

Meij

2013

Veterinary Quarterly

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Both spondylosis and diffuse idiopathic skeletal hyperostosis (DISH) are prevalent in humans and are considered distinct entities. Nowadays, the term spondylosis is in the biomedical literature mostly used when also degenerative disc disease is present. In companion animals, many reports on spondylosis, often without intervertebral disc degeneration, are described. The nomenclature and the definitions of both spondylosis and DISH in the biomedical and veterinary literature should be more in line to facilitate comparison. DISH occurs in dogs but has not been described in cats yet. DISH and spondylosis can co-occur in dogs in one animal. Boxers may serve as translational disease models for the elucidation of the gene(s) involved in the (etio)pathogenesis of DISH or serve as a test population for newly developed treatment options.

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Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Spinal hyperostosis in humans and companion animals

Kranenburg

Hazewinkel

Meij

2013

Veterinary Quarterly

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“…33 has shown association of DISH and diabetes mellitus. In the study done by Sencan D. 34 prevalence of DISH was 12% in diabetics as compared to 6.8% in the control group.…”

Section: Neuroarthropathymentioning

confidence: 99%

A Clinical Study of Rheumatological Manifestations in Patients With Type 2 Diabetes Mellitus

Venkataravanappa¹,

Huchappa²

2015

jemds

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OBJECTIVESType 2 diabetes mellitus is associated with various rheumatological manifestations that are debilitating and affect the quality of life. The present study is about prevalence of rheumatological manifestations in type 2 diabetics. METHODSThe current study is a cross sectional study with 100 patients of type 2 diabetics and 50 patients of age and sex matched non diabetics were examined for rheumatological manifestations during the period July 2008 to July 2010. The Rheumatological manifestations are documented and prevalence rates were calculated in percent of total cases in each group using Fisher's exact test and Chi-square test. RESULTSRheumatological manifestations were seen in 31% patients with type 2 diabetes mellitus compared to 16% in non-diabetics. Periarthritis of shoulder was seen in 18% diabetics compared to 4% in non-diabetics and was statistically significant. Diffuse idiopathic skeletal hyperostosis was observed in 3% of diabetics. Osteoarthritis of knee was noted in 8% of diabetics compared to 10% of non-diabetics. Carpal tunnel syndrome was seen in 3% of diabetics and 2% non-diabetics. The manifestations were more predominant in females 43.6% as compared to males 23%. CONCLUSIONRheumatological manifestations are more prevalent in type 2 diabetics than non-diabetics especially periarthritis of shoulder.

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“…No association between these two conditions has been reported in our knowledge. Other differential diagnoses for hyperostosis include post-traumatic, metabolic conditions such as diabetes mellitus (16), acromegaly (17). Treatment options for osteoporosis in this patient include dietary and life style modification and vitamin D and calcium supplements.…”

Section: Concomitant Extraspinal Hyperostosis and Osteoporosis In A Pmentioning

confidence: 99%

Concomitant extraspinal hyperostosis and osteoporosis in a patient with congenital ichthyosis

Torkamani

Phal

Savarirayan

et al. 2016

ccmbm

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SummaryIchthyosiform dermatosis is a term referred to a group of disorders that have as their basis a disorder of keratinization (1). These conditions which are present at birth result in a generalized dry, scaly skin without any inflammation. There are several types of ichthyosis based on their clinical presentation and mode of inheritance. The most common types are: ichthyosis vulgaris, X-linked recessive ichthyosis, epidermolytic hyperkeratosis (bullous), lamellar ichthyosis and non-bullous ichthyosiform erythroderma. Lamellar ichthyosis, which is inherited in an autosomal recessive pattern, shows genetic heterogeneity with the most severe type being due to mutations in the transglutaminase-1 gene. This condition presents with skin changes at birth and cases are referred to as collodion babies. Initially, the stratum corneum is smooth and appears as though it is covered with cellophane. This layer is discarded a few days after birth, leaving a generalized inflamed and scaly appearance. The skin is tight at this stage and may cause ectropion, and difficulties in feeding and temperature regulation. Lamellar ichthyosis is characterized by plate-like scales that last for life and can significantly impact the patient's quality of life (2). We report here a case of multiple extraspinal hyperostoses concomitant with marked osteoporosis and vitamin D deficiency in a patient taking acitretin for 20 years due to severe congenital lamellar ichthyosis.

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The prevalence of diffuse idiopathic skeletal hyperostosis in patients with diabetes mellitus

Abstract: We found no statistically significant difference in the prevalence of DISH between patients with DM and controls. We suggest that the factors thought to be responsible for the etiopathogenesis of DISH such as DM, insulin, and insulin-like growth factor-1 be investigated further.

Cited by 85 publications

References 15 publications

Spinal hyperostosis in humans and companion animals

Spinal hyperostosis in humans and companion animals

A Clinical Study of Rheumatological Manifestations in Patients With Type 2 Diabetes Mellitus

Concomitant extraspinal hyperostosis and osteoporosis in a patient with congenital ichthyosis

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