The prevalence of diffuse idiopathic skeletal hyperostosis in Japan – the first report of measurement by CT and review of the literature

Hirasawa, Atsuhiko; Wakao, Norimitsu; Kamiya, Mitsuhiro; Takeuchi, Mikinobu; Kawanami, Katsuhisa; Murotani, Kenta; Matsuo, Toshihiro; Deie, Masataka

doi:10.1016/j.jos.2016.02.001

Cited by 74 publications

(79 citation statements)

References 16 publications

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“…10,[15][16][17][18] In recent years, the accuracy in diagnosis of this disease has been improved by the use of CT instead of radiography, resulting in an approximately 25% increase in the number of DISH cases reported. [10][11][12][13][14][15][16][17][18] The prevalence of DISH increases with advanced age and is associated with sex (male) and complications caused by diabetes mellitus or obesity. [19][20][21][22] However, there are many unresolved questions about the pathophysiology of DISH, and it is unknown how quickly ossification progresses.…”

Section: Discussionmentioning

confidence: 99%

“…These results are comparable to the findings in a previous report. 10 Mata et al 28 scored ligament ossification using anteroposterior and lateral radiographs of the cervical, thoracic, and lumbar spinal column; lateral views of both malleoli, heels, and elbows; and anteroposterior views of the pelvis and shoulder in 55 patients with DISH and 35 patients with spondylosis, assigning a score of 0 to cases with no ossification, a score of 1 to cases with ligament ossification but without bridging, a score of 2 to cases with incomplete bridging, and score of 3 to cases with complete ossification (Table 1). They reported that scoring would enable quantitative analysis of the relationship of changes in ligament ossification and diagnostic imaging findings to the clinical features.…”

Section: Discussionmentioning

confidence: 99%

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Progression of Ossification of the Anterior Longitudinal Ligament Associated With Diffuse Idiopathic Skeletal Hyperostosis by Age: A Study of Computed Tomography Findings Over 5 Years

Murakami

Morino

Hino

et al. 2020

Global Spine Journal

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Study Design: Observational study. Objective: To investigate whether the progression of anterior longitudinal ligament ossification varies by age among patients with diffuse idiopathic skeletal hyperostosis (DISH). Methods: Of the patients who underwent computed tomography (CT) of the thoracic to pelvic region at least twice from 2009 to 2018, 191 who underwent CT at an interval of 5 years and 0 months to 5 years and 2 months were enrolled (87 men and 104 women). Sex, age at the time of the first CT scan, the presence/absence of DISH, level of complete vertebral body fusion associated with DISH, and extent of ligament ossification using the modified Mata scoring system were investigated. Results: DISHs were detected in 53 (27.7%) of 191 patients. The score of ligament ossification increased over time in 35 (66%) of 53 patients; 93 intervertebral spaces were affected. The percentage of completely fused intervertebral spaces increased by 6.7% from 31.3% to 38.0% over time. The increase in score for all intervertebral spaces in individual patients was significantly greater in the ≤70 years old group (2.7 ± 2.8 points, n = 28) than in the ≥71 years old group (1.2 ± 1.4 points; n = 25; P = .028). The mean age of patients with a recorded score that increased by ≥1 point was 67.4 years and that of patients without any change in the score was 73.3 years ( P = .036). Thus, patients with recorded changes in the score were younger. Conclusion: During the approximately 5-year period, ossification progressed more in younger patients than in older patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Progression of Ossification of the Anterior Longitudinal Ligament Associated With Diffuse Idiopathic Skeletal Hyperostosis by Age: A Study of Computed Tomography Findings Over 5 Years

Murakami

Morino

Hino

et al. 2020

Global Spine Journal

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“…Indications for surgical intervention are a lack of improvement after conservative treatment, symptoms intensification with weight loss, as well as the appearance of "red flags" or extraesophageal symptoms (dysphonia, aspiration pneumonia, dyspnea, etc.) [2,21,22,23]. In extreme cases, patients are unable to consume solid food, only semi-solid or liquid.…”

Section: Discussionmentioning

confidence: 99%

Dysphagia as a symptom of anterior cervical hyperostosis – Case report

Węgłowski¹,

Piech²

2020

Ann Agric Environ Med.

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Degenerative lesions with hyperostosis on the anterior surface of cervical spine are common in clinical practice. In addition to pain being an effect of spinal dysfunction, they sometimes cause difficulties in swallowing or speaking as well as breathing disorders. A 52-year-old farmer with 4-year history of gradually intensifying dysphagia was admitted to hospital due to inability to intake a solid food, significant weight loss, and because of the appearance of a new symptom-dysphonia. Previous conservative treatment for swallow difficulties was ineffective. CT revealed a bone excrescence on the anterior surface of two cervical vertebrae which caused an oesophageal obstruction and compression of the vocal folds. Structural abnormalities of cervical spine should be considered in differential diagnosis of symptoms from the oesophagus and upper respiratory tract, especially when a first-line conservative treatment is not effective. In these cases, surgical removal of the osteophyte is an effective way of treatment.

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“…1 The prevalence of DISH is reported to be as high as 27.1%, increasing with age and demonstrating a male preponderance of up to 6:1. 2,3 DISH affecting the cervical vertebrae can be referred to as anterolateral cervical hyperostosis (ACH). ACH is seen in up to 78% of DISH cases 1 and is associated with clinical symptoms including: reduced range of movement, dysphagia, dysphonia and dyspnoea.…”

Section: Introductionmentioning

confidence: 99%

The surgical management of dysphagia secondary to diffuse idiopathic skeletal hyperostosis

Jonathan

Sayal

Prezerakos

et al. 2018

Clinical Neurology and Neurosurgery

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The prevalence of diffuse idiopathic skeletal hyperostosis in Japan – the first report of measurement by CT and review of the literature

Abstract: The prevalence of DISH based on CT was 27.1%, which was higher than that of x-ray. In addition, intra- and inter-observer error by review of CT was less than that of x-ray. CT evaluation would be a better method for precise understanding of the state of DISH.

Cited by 74 publications

References 16 publications

Progression of Ossification of the Anterior Longitudinal Ligament Associated With Diffuse Idiopathic Skeletal Hyperostosis by Age: A Study of Computed Tomography Findings Over 5 Years

Progression of Ossification of the Anterior Longitudinal Ligament Associated With Diffuse Idiopathic Skeletal Hyperostosis by Age: A Study of Computed Tomography Findings Over 5 Years

Dysphagia as a symptom of anterior cervical hyperostosis – Case report

The surgical management of dysphagia secondary to diffuse idiopathic skeletal hyperostosis

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