The prevalence of different HPV types in Turkish women with a normal Pap smear

Abstract

The age-specific human papillomavirus (HPV) seroprevalence and HPV type distribution in women with normal cervical cytology were studied. Cervical smear samples obtained using liquid-based smears from 582 clinically healthy women aged between 15 and 68 years from five centers from four different regions of Turkey, were studied between February 2010 and January 2011. Overall, 530 of the women with normal cytology were included and the samples were analyzed for the presence of HPV by AmpliTaq. Positive samples were typed further for 37 different HPV genotypes by a line blot assay. HPV was positive in 17.9% of the women. HPV prevalence was highest in the age group of 25-29 years (31.8%), and decreased with increasing age. HPV 16 was the most common type (3.6%) followed by type 6 (2.6%) and type 45 (2.2%). Types 11 and 18 were rare (0.6% and 0.4%, respectively). Among the risk factors, number of sexual partners and parity were positively correlated with HPV positivity. In the present study, a large number of sex partners and high parity increased the risk for HPV infection. The age-specific distribution of HPV in women with normal Pap smears did not show a U-shaped curve in contrast to European countries and the USA.

High-risk HPV prevalence, HPV types and HPV concordance with concurrently applied liquid-based cervical cytology in HPV-analyzed patients by using real time PCR method.

“…Therefore, the importance of cytological screening methods to detect lesions at an early phase of infection is clear. [3,7] In our study, HPV DNA-positivity was detected in 33.7% of the cases without cytological atypia. As a result, these patients were clinically monitored.…”

“…In other studies, HPV prevalence rates have ranged between 17.9% and 67.7%. [7,9,12,13] In the present study, HPV prevalence was reported as 41.1%. Our results are similar to those indicated by Kasap et al [13] from Turkey, and they are consistent with the world literature.…”

“…[6,8] Alternatively, some literature studies have indicated that the prevalence of a second peak related to age is decreasing. [1,7,8,18] In our study, HPV prevalence was higher in age the groups of those younger than 30 and older than 55 years of age. Our study was the first in this country to demonstrate a bimodal age distribution.…”

“…It has been emphasized that rather than contracting a new infection at an advanced age, a depressed immune system may be responsible for reactivation of a persistent, latent, high-risk HPV infection. [6,7] The second peak has been associated with factors that may be due to HPV types, host propensity, and previous screening programs. [6,8] Alternatively, some literature studies have indicated that the prevalence of a second peak related to age is decreasing.…”

Birinci Basamağa Başvuran Doğurganlık Çağındaki Kadınların Human Papilloma Virus (HPV) ve HPV Aşısı Hakkındaki Bilgi Düzeyleri

“…As well as being the second cancer type that is the most common among women in the world, cervical cancer is the second most common reason for the cancer deaths [1][2][3][4] . According to the data revealed by Turkish Ministry of Health, while Araştırma Makalesi / Research Article cervical cancer incidence rate was 0.7/100000 in 1996, it increased up to 3.87/100000 in 2007 5 .…”